scholarly journals Ovine Pulmonary Adenocarcinoma: A Large Animal Model for Human Lung Cancer

ILAR Journal ◽  
2015 ◽  
Vol 56 (1) ◽  
pp. 99-115 ◽  
Author(s):  
G. Youssef ◽  
W. A. H. Wallace ◽  
M. P. Dagleish ◽  
C. Cousens ◽  
D. J. Griffiths
Keyword(s):  
Lung Cancer ◽  
Animal Model ◽  
Human Lung ◽  
Pulmonary Adenocarcinoma ◽  
Human Lung Cancer ◽  
Large Animal Model ◽  
Large Animal ◽  
Ovine Pulmonary Adenocarcinoma

scholarly journals Transcriptional Response of Ovine Lung to Infection with Jaagsiekte Sheep Retrovirus

2019 ◽  
Vol 93 (21) ◽  
Author(s):  
Anna Eleonora Karagianni ◽  
Deepali Vasoya ◽  
Jeanie Finlayson ◽  
Henny M. Martineau ◽  
Ann R. Wood ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Animal Model ◽  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Transcriptional Response ◽  
Human Lung Cancer ◽  
Ovine Pulmonary Adenocarcinoma ◽  
Jaagsiekte Sheep Retrovirus ◽  
Human Lung Adenocarcinoma ◽  
Naturally Occurring

ABSTRACT Jaagsiekte sheep retrovirus (JSRV) is the etiologic agent of ovine pulmonary adenocarcinoma (OPA), a neoplastic lung disease of sheep. OPA is an important economic and welfare issue for sheep farmers and a valuable naturally occurring animal model for human lung adenocarcinoma. Here, we used RNA sequencing to study the transcriptional response of ovine lung tissue to infection by JSRV. We identified 1,971 ovine genes differentially expressed in JSRV-infected lung compared to noninfected lung, including many genes with roles in carcinogenesis and immunomodulation. The differential expression of selected genes was confirmed using immunohistochemistry and reverse transcription-quantitative PCR. A key finding was the activation of anterior gradient 2, yes-associated protein 1, and amphiregulin in OPA tumor cells, indicating a role for this oncogenic pathway in OPA. In addition, there was differential expression of genes related to innate immunity, including genes encoding cytokines, chemokines, and complement system proteins. In contrast, there was little evidence for the upregulation of genes involved in T-cell immunity. Many genes related to macrophage function were also differentially expressed, reflecting the increased abundance of these cells in OPA-affected lung tissue. Comparison of the genes differentially regulated in OPA with the transcriptional changes occurring in human lung cancer revealed important similarities and differences between OPA and human lung adenocarcinoma. This study provides valuable new information on the pathogenesis of OPA and strengthens the use of this naturally occurring animal model for human lung adenocarcinoma. IMPORTANCE Ovine pulmonary adenocarcinoma is a chronic respiratory disease of sheep caused by jaagsiekte sheep retrovirus (JSRV). OPA is a significant economic problem for sheep farmers in many countries and is a valuable animal model for some forms of human lung cancer. Here, we examined the changes in host gene expression that occur in the lung in response to JSRV infection. We identified a large number of genes with altered expression in infected lung, including factors with roles in cancer and immune system function. We also compared the data from OPA to previously published data from human lung adenocarcinoma and found a large degree of overlap in the genes that were dysregulated. The results of this study provide exciting new avenues for future studies of OPA and may have comparative relevance for understanding human lung cancer.

scholarly journals A Novel Translational Ovine Pulmonary Adenocarcinoma Model for Human Lung Cancer

2019 ◽  
Vol 9 ◽  
Author(s):  
Mark E. Gray ◽  
Paul Sullivan ◽  
Jamie R. K. Marland ◽  
Stephen N. Greenhalgh ◽  
James Meehan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Human Lung ◽  
Pulmonary Adenocarcinoma ◽  
Human Lung Cancer ◽  
Ovine Pulmonary Adenocarcinoma

Pyrogallol induces G2-M arrest in human lung cancer cells and inhibits tumor growth in an animal model

Lung Cancer ◽  
2009 ◽  
Vol 66 (2) ◽  
pp. 162-168 ◽  
Author(s):  
Chih-Jen Yang ◽  
Chuan-Sheng Wang ◽  
Jen-Yu Hung ◽  
Hurng-Wern Huang ◽  
Yi-Chen Chia ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Animal Model ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

Abstract 44: Monitoring of metastasis by detection ofEGFRmutation, T790M, with plasma using animal model for metastasis of human lung cancer

2014 ◽  
Author(s):  
Naoko Aragane ◽  
Akemi Sato ◽  
Naomi Kobayashi ◽  
Yumi Nagano ◽  
Eisaburo Sueoka ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Animal Model ◽  
Human Lung ◽  
Human Lung Cancer

Ovine pulmonary adenocarcinoma as an animal model of progressive lung cancer and the impact of nutritional selenium supply

2011 ◽  
Vol 25 ◽  
pp. S30-S34 ◽  
Author(s):  
Esther Humann-Ziehank ◽  
Petra Wolf ◽  
Kostja Renko ◽  
Lutz Schomburg ◽  
Michael Ludwig Bruegmann ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Animal Model ◽  
Pulmonary Adenocarcinoma ◽  
Ovine Pulmonary Adenocarcinoma ◽  
The Impact

scholarly journals Refinement of an Animal Model for Research on Metastatic Lymph Nodes of Human Lung Cancer

Haigan ◽  
2004 ◽  
Vol 44 (7) ◽  
pp. 767-771
Author(s):  
Eiki Mizutani ◽  
Hidenori Inoue ◽  
Hirochika Matsubara ◽  
Kentaro Kamiya ◽  
Satsuki Kina ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Animal Model ◽  
Lymph Nodes ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph
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