scholarly journals Andrographolide Exerts Significant Antidepressant-Like Effects Involving the Hippocampal BDNF System in Mice

2019 ◽  
Vol 22 (9) ◽  
pp. 585-600 ◽  
Author(s):  
Jing-Jing Zhang ◽  
Ting-Ting Gao ◽  
Yuan Wang ◽  
Jin-Liang Wang ◽  
Wei Guan ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Forced Swim Test ◽  
Tail Suspension Test ◽  
Brain Derived Neurotrophic Factor ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Tail Suspension ◽  
Swim Test ◽  
Signalling Cascade ◽  
Suspension Test

Abstract Background Major depressive disorder is a worldwide neuropsychiatric disorder associated with various symptoms, but current antidepressants used in clinical practice have various side effects and high failure rates. Andrographolide is the main bioactive ingredient of Andrographis paniculata and exhibits numerous pharmacological actions. This study aimed to evaluate the antidepressant-like effects of andrographolide in male C57BL/6J mice. Methods The antidepressant-like effects of andrographolide in mice were explored in a forced swim test, tail suspension test, and chronic unpredictable mild stress model of depression. Western blotting and immunofluorescence were further performed to assess the effects of chronic unpredictable mild stress and andrographolide on the brain-derived neurotrophic factor signalling cascade and hippocampal neurogenesis. Moreover, a pharmacological inhibitor (K252a) and a lentiviral-short hairpin RNA (LV-TrkB-shRNA) were used to clarify the antidepressant-like mechanism of andrographolide. Results Andrographolide exhibited antidepressant-like potential in the forced swim test and tail suspension test without influencing the locomotor activity of mice. Repeated andrographolide treatment not only produced significant antidepressant-like effects in the chronic unpredictable mild stress model but also prevented the decreasing effects of chronic unpredictable mild stress on hippocampal brain-derived neurotrophic factor signalling and neurogenesis in mice. Importantly, blockade of the hippocampal brain-derived neurotrophic factor system by K252a and TrkB-shRNA fully abolished the antidepressant-like effects of andrographolide in mice. Conclusions Andrographolide exerts antidepressant-like effects in mice via promoting the hippocampal brain-derived neurotrophic factor signalling cascade.

Albiflorin Ameliorates Depressive-like Behaviors in Mice Induced by Chronic Unpredictable Mild Stress

2019 ◽  
Vol 18 (1) ◽  
pp. 102-107
Author(s):  
Wang Jun ◽  
Wan Yanfang ◽  
Zheng Nan
Keyword(s):  
Forced Swim Test ◽  
Tail Suspension Test ◽  
Underlying Mechanism ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Tail Suspension ◽  
Sucrose Consumption ◽  
Swim Test ◽  
Forced Swim ◽  
Suspension Test

Depression is a common psychiatric disorder with a high recurrence rate leading to suicidal thoughts in some cases. Albiflorin is a monoterpene glycoside that is commonly used in the treatment of psychiatric disorders. However, the underlying mechanism of albiflorin on depression is unclear and remains to be investigated. To this end, a mouse model of depression was established via chronic unpredictable mild stress treatment. Next, the effects of albiflorin on depression in these mice were evaluated using the sucrose preference test, forced swim test, tail suspension test, and open field test. The results showed that chronic unpredictable mild stress decreased sucrose consumption, while albiflorin (10 mg/kg) treatment significantly increased sucrose consumption just as fluoxetine (10 mg/kg), a drug commonly used to treat depression. Moreover, both albiflorin and fluoxetine demonstrated significant decrease in immobility time in the forced swim test and tail suspension test with no change in spontaneous locomotor activities. Finally, the underlying mechanism of albiflorin was evaluated using western blot. Results showed an up-regulation of phospho-Akt without changing total-Akt, indicating that albiflorin improved the depression symptoms via inactivation of the Akt signaling pathway. Therefore, albiflorin might be a potential therapeutic treatment for depression.

scholarly journals Evaluation of antidepressant activity of tramadol in comparison with imipramine in Swiss albino mice

2017 ◽  
Vol 6 (3) ◽  
pp. 695
Author(s):  
Chiranjeevi Bonda ◽  
Sudhir Pawar ◽  
Jaisen Lokhande
Keyword(s):  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Group I ◽  
Immobility Time ◽  
Suspension Test

Background: The aim of the study was to evaluate the antidepressant effect of opioid analgesic tramadol using forced swim test and tail suspension test models.Methods: The antidepressant effect was assessed by recording the immobility time in Forced swim test (FST) and Tail suspension test (TST). The mice were randomly divided into five groups. Mice belonging to group I was given normal saline (0.1ml/kg) which acted as control. Group II received imipramine (15mg/kg) considered as the standard drug tramadol was given in graded dose (10, 20 and 40 mg/kg) to mice of groups III, IV, V respectively. All drugs were administered intraperitoneally for seven successive days; test was done on 7th day.Results: Tramadol and Imipramine showed antidepressant activity when compared to control. There is dose dependent increase in antidepressant activity of tramadol. The antidepressant activity of imipramine was significantly (P<0.05) more than tramadol at dose 10 and 20 mg/kg but antidepressant activity with tramadol 40mg/kg was comparable to imipramine treated mice.Conclusions: The results of this study indicated the presence of antidepressant activity of tramadol at 40mg/kg.

scholarly journals EFFECT OF FLAVONE AND ITS MONOHYDROXY DERIVATIVES ON ANIMAL MODELS OF DEPRESSION IN SWISS ALBINO MICE

2019 ◽  
pp. 513-517
Author(s):  
SHANMUGAPRIYAN S ◽  
JAIKUMAR S ◽  
VISWANATHAN S ◽  
PARIMALA K ◽  
RAJESH M
Keyword(s):  
Animal Models ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Animal Models Of Depression ◽  
Pre Treatment ◽  
Suspension Test

Objectives: This research was designed to investigate the antidepressant activity of a few structurally related flavones (flavone, 3‑hydroxyflavone, and 7‑hydroxyflavone) and the possible mechanisms involved. Methods: Antidepressant activity was evaluated in mice by subjecting them to forced swim test and tail suspension test. The involvement of adrenergic, serotonergic, nitric oxide (NO), and opioid mechanisms was investigated using suitable interacting chemicals. Results: Flavone, 3‑hydroxyflavone, and 7‑hydroxyflavone exhibited a significant and dose‑dependent reduction in total time of immobility in the forced swim test and tail suspension test. Pre‑treatment with alpha‑methyl‑para‑tyrosine and parachlorophenyl alanine attenuated the reduction in immobility period produced by flavone and its derivatives in forced swim test. Naloxone pre‑treatment partially reversed the effect of flavone while L‑arginine pre‑treatment did not alter their effect. Conclusion: The investigated flavones exhibited promising antidepressant activity in both the animal models of depression. However, the flavone compounds did not alter the motor coordination and ambulatory behavior in the Rotarod and locomotor activity test. The participation of serotonergic, adrenergic, and opioid mechanism in the antidepressant activity of these compounds was elucidated from the results, and the role of NO pathway was excluded.

Synthesis and Antidepressant activity of pyrazoline based MAO-inhibitors

2016 ◽  
Vol 3 (1) ◽  
pp. 1 ◽  
Author(s):  
Vishnu Nayak Badavath ◽  
Alok Kumar ◽  
Surender Singh Jadav ◽  
Ashok Kumar Pattnaik ◽  
Venkatesan Jayaprakash ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Mao Inhibitors ◽  
Tail Suspension ◽  
Swim Test ◽  
Plus Maze ◽  
Behavioral Despair Test ◽  
Suspension Test

A series of nine 3-(2-hydroxyphenyl)-5-aryl-N-phenyl-4,5-dihydropyrazole-1-carbothioamide derivative s (3a-3i) that were earlier reported as potent rMAO-A inhibitors were evaluated for their antidepressant activity in Porsolt's behavioral despair test (forced swim test) and Tail Suspension test activity, among them, compounds (3e and 3h) were found to have potent antidepressant activity. Reduction in duration of immobility was significant for all the compounds in Porsolts swim test compared with tail suspension test. 3h was further evaluated for anxiolytic activity in Elevated plus maze and was found to be devoid of it.

scholarly journals PHYTOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF COMMIPHORA MUKUL FOR ANTIDEPRESSANT ACTIVITY IN ALBINO MICE

2016 ◽  
Vol 10 (1) ◽  
pp. 360
Author(s):  
Vijetha Pendyala ◽  
Ramesh Babu Janga ◽  
Vidyadhara Suryadevara
Keyword(s):  
Ethyl Acetate ◽  
Petroleum Ether ◽  
Forced Swim Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Phytochemical Screening ◽  
Tail Suspension ◽  
Swim Test ◽  
Commiphora Mukul ◽  
Suspension Test

ABSTRACTObjective: The main aim and objective of the present study is to investigate the effect of Commiphora mukul (Family: Burseraceae), on depression inmice using tail suspension test (TST) and forced swim test (FST).Methods: The oleo-gum resin of guggul was extracted with alcohol and fractionated with ethyl acetate and petroleum ether. All the fractions weresubjected for preliminary phytochemical screening, using various qualitative tests. Till date, no scientific data were available on the antidepressantactivity of this plant. So, in the present investigation, TST and FST are selected as animal models for evaluation of antidepressant activity in albinomice.Results: The preliminary phytochemical screening of guggul has revealed the presence of carbohydrates, proteins, tannins, and flavonoids inhydroalcoholic fraction. Ethyl acetate fraction showed positive results toward flavonoids, alkaloids, proteins, and steroids. Hydroalcoholic, ethylacetate, and petroleum ether fractions (50 and 100 mg/kg p.o.) of guggul administered orally for 14 successive days had decreased the immobilityperiods significantly in a dose-dependent manner in both TST and FST, showing significant antidepressant-like activity. The activities of the fractionswere found to be comparable to imipramine in both FST and TST.Conclusions: Although a number of synthetic drugs are being used as standard treatment for clinically depressed patient, they have adverse effectsthat can compromise the therapeutic treatment. In the traditional systems of medicine, many plants and formulations have been used to treatdepression for thousands of years. The results of this study indicate the potential for the use of guggul as an adjuvant in the treatment of depression.Keywords: Guggul, Commiphora mukul, Antidepressant activity, Forced swim test, Tail suspension test, Depression.

Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice

Life Sciences ◽  
2007 ◽  
Vol 81 (11) ◽  
pp. 933-938 ◽  
Author(s):  
Wen-Huang Peng ◽  
Kuan-Lin Lo ◽  
Yi-Hsuen Lee ◽  
Tai-Huang Hung ◽  
Ying-Chih Lin
Keyword(s):  
Forced Swim Test ◽  
Tail Suspension Test ◽  
Tail Suspension ◽  
Swim Test ◽  
Forced Swim ◽  
Suspension Test
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