scholarly journals Regionally Specific Effects of Oxytocin on Reinstatement of Cocaine Seeking in Male and Female Rats

2018 ◽  
Vol 21 (7) ◽  
pp. 677-686 ◽  
Author(s):  
Rachel A Weber ◽  
Carly N Logan ◽  
Kah-Chung Leong ◽  
Joanna Peris ◽  
Lori Knackstedt ◽  
...  
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Specific Effects ◽  
Male And Female Rats ◽  
Cocaine Seeking

scholarly journals Attenuated cocaine-seeking after oxytocin administration in male and female rats

2018 ◽  
Vol 235 (7) ◽  
pp. 2051-2063 ◽  
Author(s):  
Amy S. Kohtz ◽  
Belle Lin ◽  
Michael E. Smith ◽  
Gary Aston-Jones
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cocaine Seeking

scholarly journals Metformin in nucleus accumbens core reduces cue-induced cocaine seeking in male and female rats

2021 ◽  
Author(s):  
Amy Chan ◽  
Alexis Willard ◽  
Sarah Mulloy ◽  
Noor Ibrahim ◽  
Allegra Sciaccotta ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Female Rats ◽  
Therapeutic Effects ◽  
Self Administration ◽  
Nucleus Accumbens Core ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cocaine Seeking ◽  
Ampk Activity ◽  
Accumbens Core

This study investigated the potential therapeutic effects of the FDA-approved drug metformin on cue-induced reinstatement of cocaine seeking. Metformin (dimethyl-biguanide) is a first-line treatment for type II diabetes that, among other mechanisms, is involved in the activation of adenosine monophosphate activated protein kinase (AMPK). Cocaine self-administration and extinction is associated with decreased levels of phosphorylated AMPK within the nucleus accumbens core (NAcore). Previously it was shown that increasing AMPK activity in the NAcore decreased cue-induced reinstatement of cocaine seeking. Decreasing AMPK activity produced the opposite effect. The goal of the present study was to determine if metformin in the NAcore reduces cue-induced cocaine seeking in adult male and female Sprague Dawley rats. Rats were trained to self-administer cocaine followed by extinction prior to cue-induced reinstatement trials. Metformin microinjected in the NAcore attenuated cue-induced reinstatement in male and female rats. Importantly, metformin's effects on cocaine seeking were not due to a general depression of spontaneous locomotor activity. In female rats, metformin's effects did generalize to a reduction in cue-induced reinstatement of sucrose seeking. These data support a potential role for metformin as a pharmacotherapy for cocaine use disorder, but warrant caution given the potential for metformin's effects to generalize to a natural reward in female rats.

Dextromethorphan affects ventilation differently in male and female rats

1996 ◽  
Vol 81 (5) ◽  
pp. 1911-1916 ◽  
Author(s):  
Evelyn H. Schlenker
Keyword(s):  
Oxygen Consumption ◽  
Aspartic Acid ◽  
Subcutaneous Administration ◽  
Female Rats ◽  
Male Rats ◽  
Male And Female ◽  
Time Points ◽  
Specific Effects ◽  
Male And Female Rats ◽  
Gender Specific

Schlenker, Evelyn H. Dextromethorphan affects ventilation differently in male and female rats. J. Appl. Physiol. 81(5): 1911–1916, 1996.—Subcutaneous administration of aspartic acid results in a long-lasting but reversible depression of ventilation in male but not in female rats. Aspartic acid acts on N-methyl-d-aspartate receptors. The present study tested the hypothesis that a noncompetitive N-methyl-d-aspartate-receptor antagonist, dextromethorphan (Dex), would depress ventilation in female rats and stimulate it in male rats. Moreover, Dex administered prior to aspartic acid should prevent the aspartic acid-induced depression of ventilation in male rats. In female rats, Dex caused a 30% depression of ventilation relative to saline at 5 and 10 mg/kg ( P < 0.01) but not at the highest dose (20 mg/kg). In male rats, Dex had no effect on ventilation. At a dose of 20 mg/kg, Dex depressed oxygen consumption to 50% of the saline value at all time points in female rats ( P < 0.001) and in male rats 45 and 60 min after administration. The time points when Dex depressed ventilation and oxygen consumption were different in female rats, suggesting that the depression of ventilation was not the result of a depression in oxygen consumption. During a hypercapnic challenge (7% CO2), female rats treated with 5 and 10 mg/kg of Dex exhibited a smaller increase in ventilatory response relative to saline treatment. At a dose of 20 mg/kg, the hypercapnic responsiveness of male rats was markedly stimulated (85.8 ± 8.95 ml/min) relative to saline (50.6 ± 9.14 ml/min; P < 0.001). Finally, Dex administered before aspartic acid prevented the aspartic acid-induced depression of ventilation in male rats. Thus, in rats, Dex has gender-specific effects on ventilation and these effects are not associated with changes in oxygen consumption.

Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats

2008 ◽  
Vol 203 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Justin J. Anker ◽  
Nathan A. Holtz ◽  
Natalie Zlebnik ◽  
Marilyn E. Carroll
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cocaine Seeking ◽  
Seeking Behavior

scholarly journals Ceftriaxone and mGlu2/3 interactions in the nucleus accumbens core affect the reinstatement of cocaine-seeking in male and female rats

2020 ◽  
Vol 237 (7) ◽  
pp. 2007-2018 ◽  
Author(s):  
Carly N. Logan ◽  
Allison R. Bechard ◽  
Peter U. Hamor ◽  
Lizhen Wu ◽  
Marek Schwendt ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Female Rats ◽  
Nucleus Accumbens Core ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cocaine Seeking ◽  
Core Affect ◽  
Accumbens Core

scholarly journals Oxytocin has sex-specific effects on social behaviour and hypothalamic oxytocin immunoreactive cells but not hippocampal neurogenesis in adult rats

2019 ◽  
Author(s):  
Paula Duarte-Guterman ◽  
Stephanie E. Lieblich ◽  
Wansu Qiu ◽  
Jared E.J. Splinter ◽  
Kimberly A. Go ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Body Mass ◽  
Hippocampal Neurogenesis ◽  
Female Rats ◽  
Brain Barrier ◽  
Social Investigation ◽  
Male And Female ◽  
Specific Effects ◽  
Male And Female Rats ◽  
17Β Estradiol

AbstractOxytocin regulates social behaviours, pair bonding and hippocampal neurogenesis but most studies have used adult males. Our study investigated the effects of oxytocin on social investigation and adult hippocampal neurogenesis in male and female rats. Oxytocin has poor penetration of the blood-brain barrier, therefore we tested a nanoparticle drug, TRIOZANTM (Ovensa Inc.), which permits greater blood-brain-barrier penetration. Adult male and female rats were injected daily (i.p.) for 10 days with either: oxytocin in PBS (0.5 or 1.0 mg/kg), oxytocin in TRIOZANTM (0.5 or 1.0 mg/kg), or vehicle (PBS) and tested for social investigation. Oxytocin decreased body mass and increased social investigation and number of oxytocin-immunoreactive cells in the supraoptic nucleus (SON) of the hypothalamus in male rats only. In both sexes, oxytocin decreased the number of immature neurons (doublecortin+ cells) in the ventral hippocampus and reduced plasma 17β-estradiol levels in a dose- and delivery-dependent way. Oxytocin in TRIOZANTM reduced sedation observed post-injection and increased some central effects (oxytocin levels in the hypothalamus and ventral hippocampus neurogenesis) relative to oxytocin in PBS indicating that the nanoparticle may be used as an alternative brain delivery system. We showed that oxytocin has sex-specific effects on social investigation, body mass, sedation, and the oxytocin system. In contrast, similar effects were observed in both sexes in neurogenesis and plasma 17β-estradiol. Our work suggests that sex differences in oxytocin regulation of brain endpoints is region-specific (hypothalamus versus hippocampus) and that oxytocin does not promote social investigation in females.

scholarly journals Orexin-1 Receptor Mediation of Cocaine Seeking in Male and Female Rats

2011 ◽  
Vol 340 (3) ◽  
pp. 801-809 ◽  
Author(s):  
Luyi Zhou ◽  
Shannon M. Ghee ◽  
Clifford Chan ◽  
Li Lin ◽  
Michael D. Cameron ◽  
...  
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Cocaine Seeking
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