scholarly journals Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer’s Disease-Like Pattern

2018 ◽  
Vol 21 (7) ◽  
pp. 640-648 ◽  
Author(s):  
Ben Chen ◽  
Xiaomei Zhong ◽  
Naikeng Mai ◽  
Qi Peng ◽  
Zhangying Wu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Late Life ◽  
Late Life Depression ◽  
Structural Abnormalities ◽  
Olfactory Identification

Cognitive impairment in remitted late-life depression is not associated with Alzheimer's disease-related CSF biomarkers

2020 ◽  
Vol 272 ◽  
pp. 409-416
Author(s):  
Júlia C. Loureiro ◽  
Florindo Stella ◽  
Marcos V. Pais ◽  
Marcia Radanovic ◽  
Paulo R. Canineu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Late Life ◽  
Csf Biomarkers ◽  
Late Life Depression

scholarly journals Cognitive Impairment in Late-Life Depression: A Comparative Study of Healthy Older People, Late-Life Depression, and Mild Alzheimer's Disease Using Multivariate Base Rates of Low Scores

2021 ◽  
Vol 12 ◽  
Author(s):  
Caroline Masse ◽  
Pierre Vandel ◽  
Géraldine Sylvestre ◽  
Nicolas Noiret ◽  
Djamila Bennabi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Older People ◽  
Clinical Decision Making ◽  
Late Life ◽  
Clinical Decision ◽  
Late Life Depression ◽  
Base Rates ◽  
Healthy Control

Late-Life Depression (LLD) is often associated with cognitive impairment. However, distinction between cognitive impairment due to LLD and those due to normal aging or mild Alzheimer's Disease (AD) remain difficult. The aim of this study was to present and compare the multivariate base rates of low scores in LLD, mild AD, and healthy control groups on a battery of neuropsychological tests. Participants (ages 60–89) were 352 older healthy adults, 390 patients with LLD, and 234 patients with mild AD (i.e., MMSE ≥ 20). Multivariate base rates of low scores (i.e., ≤ 5th percentile) were calculated for each participant group within different cognitive domains (verbal episodic memory, executive skills, mental processing speed, constructional praxis, and language/semantic memory). Obtaining at least one low score was relatively common in healthy older people controls (from 9.4 to 17.6%), and may thus result in a large number of false positives. By contrast, having at least two low scores was unusual (from 0.3 to 4.6%) and seems to be a more reliable criterion for identifying cognitive impairment in LLD. Having at least three low memory scores was poorly associated with LLD (5.9%) compared to mild AD (76.1%) and may provide a useful way to differentiate between these two conditions [χ(1)2 = 329.8, p < 0.001; Odds Ratio = 50.7, 95% CI = 38.2–77.5]. The multivariate base rate information about low scores in healthy older people and mild AD may help clinicians to identify cognitive impairments in LLD patients, improve the clinical decision-making, and target those who require regular cognitive and clinical follow-up.

Late-Life Depression versus Amnestic Mild Cognitive Impairment: Alzheimer’s Disease Incidence in 4 Years of Follow-Up

2018 ◽  
Vol 46 (3-4) ◽  
pp. 140-153 ◽  
Author(s):  
Michele Lauriola ◽  
Antonio Mangiacotti ◽  
Grazia D’Onofrio ◽  
Leandro Cascavilla ◽  
Francesco Paris ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Medical Condition ◽  
Disease Incidence ◽  
Late Life ◽  
Amnestic Mild Cognitive Impairment ◽  
Late Life Depression

Background/Aim: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer’s disease (AD) within 4 years of follow-up. Methods: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years. Results: The risk to develop AD, within 4 years, was 68.33% for aMCI and 49.57% for LLD. In AD patients 5.60% deteriorated without depression, and 72.20% deteriorated with depression after 4 years of follow-up (p < 0.0001). No HC patients deteriorated to AD or any other dementia type. Conclusion: In our results, aMCI was the first predictive condition that increased the risk to develop AD. Depression is a potentially preventable medical condition across the lifespan and may be a modifiable risk factor.

scholarly journals Late-Life Depression as a Risk Factor for Mild Cognitive Impairment or Alzheimer's Disease in 30 US Alzheimer's Disease Centers

2012 ◽  
Vol 31 (2) ◽  
pp. 265-275 ◽  
Author(s):  
Kyle Steenland ◽  
Conny Karnes ◽  
Ryan Seals ◽  
Claudine Carnevale ◽  
Adriana Hermida ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Late Life ◽  
Late Life Depression

scholarly journals Pathways linking late-life depression to persistent cognitive impairment and dementia

2008 ◽  
Vol 10 (3) ◽  
pp. 345-357 ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Cerebrovascular Disease ◽  
Clinical Status ◽  
Late Life ◽  
Cognitive Outcomes ◽  
Late Life Depression ◽  
Increased Risk ◽  
The Impact

There is a strong association between late-life depression, cognitive impairment, cerebrovascular disease, and poor cognitive outcomes, including progressive dementia, especially Alzheimer's disease. While neuroimaging evidence suggests that cerebrovascular disease plays a prominent role, it seems that depression alone may also confer substantial risk for developing Alzheimer's disease. The relationships between the prominent cerebrovascular changes, other structural abnormalities, specific forms of cognitive dysfunction, and increased risk for developing Alzheimer's disease among those with late-life depression have been difficult to reconcile. The varied findings suggest that there are likely multiple pathways to poor cognitive outcomes. We present a framework outlining multiple, non-mutually exclusive etiologic links between depression, cognitive impairment, and progressive decline, including dementia. Importantly, the model is both testable and falsifiable. Going forward, using models such as this to inform research should accelerate knowledge acquisition on the depression/dementia relationship that may be useful for dementia prevention, monitoring the impact of depression treatment on clinical status and course of illness.

scholarly journals When Cognitive Decline and Depression Coexist in the Elderly: CSF Biomarkers Analysis Can Differentiate Alzheimer's Disease from Late-Life Depression

2018 ◽  
Vol 10 ◽  
Author(s):  
Claudio Liguori ◽  
Mariangela Pierantozzi ◽  
Agostino Chiaravalloti ◽  
Giulia M. Sancesario ◽  
Nicola B. Mercuri ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Late Life ◽  
The Elderly ◽  
Csf Biomarkers ◽  
Late Life Depression
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