scholarly journals Diurnal Oscillation of Amygdala Clock Gene Expression and Loss of Synchrony in a Mouse Model of Depression

2015 ◽  
Vol 18 (5) ◽  
Author(s):  
Giorgia Savalli ◽  
Weifei Diao ◽  
Stefan Schulz ◽  
Kristina Todtova ◽  
Daniela D. Pollak
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Clock Gene ◽  
Diurnal Oscillation ◽  
Clock Gene Expression

Alteration of clock gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

2010 ◽  
Vol 68 ◽  
pp. e81-e82
Author(s):  
Akane Hayashi ◽  
Naoya Matsunaga ◽  
Eriko Ikeda ◽  
Satoru Koyanagi ◽  
Shigehiro Ohdo
Keyword(s):  
Gene Expression ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Clock Gene ◽  
Clock Gene Expression

scholarly journals Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH

2016 ◽  
Vol 1861 (7) ◽  
pp. 584-593 ◽  
Author(s):  
Kimberley D. Bruce ◽  
Dawid Szczepankiewicz ◽  
Kiran K. Sihota ◽  
Manoj Ravindraanandan ◽  
Hugh Thomas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Clock Gene ◽  
Redox Status ◽  
Cellular Redox ◽  
Clock Gene Expression

scholarly journals Western diet-induced obesity disrupts the diurnal rhythmicity of hippocampal core clock gene expression in a mouse model

2020 ◽  
Vol 88 ◽  
pp. 815-825 ◽  
Author(s):  
Lauren N. Woodie ◽  
Robert M. Johnson ◽  
Bulbul Ahmed ◽  
Savanah Fowler ◽  
William Haynes ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Clock Gene ◽  
Western Diet ◽  
Clock Gene Expression ◽  
Diet Induced Obesity ◽  
Core Clock Gene ◽  
Diurnal Rhythmicity

Daily rhythm and regulation of clock gene expression in the rat pineal gland

2004 ◽  
Vol 120 (2) ◽  
pp. 164-172 ◽  
Author(s):  
V Simonneaux ◽  
V.-J Poirel ◽  
M.-L Garidou ◽  
D Nguyen ◽  
E Diaz-Rodriguez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pineal Gland ◽  
Clock Gene ◽  
Daily Rhythm ◽  
Clock Gene Expression ◽  
Rat Pineal Gland

A genetic CLOCK variant associated with cluster headache causing increased mRNA levels

Cephalalgia ◽  
2017 ◽  
Vol 38 (3) ◽  
pp. 496-502 ◽  
Author(s):  
Carmen Fourier ◽  
Caroline Ran ◽  
Margret Zinnegger ◽  
Anne-Sofie Johansson ◽  
Christina Sjöstrand ◽  
...  
Keyword(s):  
Gene Expression ◽  
Circadian Rhythm ◽  
Cluster Headache ◽  
Clock Gene ◽  
Control Sample ◽  
Mrna Levels ◽  
Nucleotide Polymorphisms ◽  
Primary Fibroblast ◽  
Clock Gene Expression ◽  
Diurnal Preference

Background Cluster headache is characterized by recurrent unilateral headache attacks of severe intensity. One of the main features in a majority of patients is a striking rhythmicity of attacks. The CLOCK ( Circadian Locomotor Output Cycles Kaput) gene encodes a transcription factor that serves as a basic driving force for circadian rhythm in humans and is therefore particularly interesting as a candidate gene for cluster headache. Methods We performed an association study on a large Swedish cluster headache case-control sample (449 patients and 677 controls) screening for three single nucleotide polymorphisms (SNPs) in the CLOCK gene implicated in diurnal preference (rs1801260) or sleep duration (rs11932595 and rs12649507), respectively. We further wanted to investigate the effect of identified associated SNPs on CLOCK gene expression. Results We found a significant association with rs12649507 and cluster headache ( p = 0.0069) and this data was strengthened when stratifying for reported diurnal rhythmicity of attacks ( p = 0.0009). We investigated the effect of rs12649507 on CLOCK gene expression in human primary fibroblast cultures and identified a significant increase in CLOCK mRNA expression ( p = 0.0232). Conclusions Our results strengthen the hypothesis of the involvement of circadian rhythm in cluster headache.

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