scholarly journals Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank

2018 ◽  
Vol 47 (4) ◽  
pp. 1229-1241 ◽  
Author(s):  
Nicole M Warrington ◽  
Rachel M Freathy ◽  
Michael C Neale ◽  
David M Evans
Keyword(s):  
Structural Equation Modelling ◽  
Structural Equation ◽  
Uk Biobank ◽  
Equation Modelling ◽  
The Uk

scholarly journals Using Structural Equation Modeling to Jointly Estimate Maternal and Foetal Effects on Birthweight in the UK Biobank

2017 ◽  
Author(s):  
Nicole M Warrington ◽  
Rachel Freathy ◽  
Michael C. Neale ◽  
David M Evans
Keyword(s):  
Structural Equation Model ◽  
Structural Equation ◽  
Equation Model ◽  
Uk Biobank ◽  
Type 1 Error ◽  
Equation Modelling ◽  
Genotype Information ◽  
Two Generations ◽  
The Uk

AbstractBackgroundTo date, 60 genetic variants have been robustly associated with birthweight. It is unclear whether these associations represent the effect of an individual’s own genotype on their birthweight, their mother’s genotype, or both.MethodsWe demonstrate how structural equation modelling (SEM) can be used to estimate both maternal and foetal effects when phenotype information is present for individuals in two generations and genotype information is available on the older individual. We conduct an extensive simulation study to assess the bias, power and type 1 error rates of the SEM and also apply the SEM to birthweight data in the UK Biobank study.ResultsUnlike simple regression models, our approach is unbiased when there is both a maternal and foetal effect. The method can be used when either the individual’s own phenotype or the phenotype of their offspring is not available, and allows the inclusion of summary statistics from additional cohorts where raw data cannot be shared. We show that the type 1 error rate of the method is appropriate, there is substantial statistical power to detect a genetic variant that has a moderate effect on the phenotype, and reasonable power to detect whether it is a foetal and/or maternal effect. We also identify a subset of birth weight associated SNPs that have opposing maternal and foetal effects in the UK Biobank.ConclusionsOur results show that SEM can be used to estimate parameters that would be difficult to quantify using simple statistical methods alone.Key MessagesWe describe a structural equation model to estimate both maternal and foetal effects when phenotype information is present for individuals in two generations and genotype information is available on the older individual.Using simulation, we show that our approach is unbiased when there is both a maternal and foetal effect, unlike simple linear regression models. Additionally, we illustrate that the structural equation model is largely robust to measurement error and missing data for either the individual’s own phenotype or the phenotype of their offspring.We describe how the flexibility of the structural equation modelling framework will allow the inclusion of summary statistics from studies that are unable to share raw data.Using the structural equation model to estimate the maternal and foetal effects of known birthweight associated loci in the UK Biobank, we identify three loci that have primary effects through the maternal genome and six loci that have opposite effects in the maternal and foetal genomes.

Novelty and Threat in the Weapon Focus Effect: A Study with Structural Equation Modelling

2013 ◽  
Author(s):  
William Blake Erickson ◽  
James Michael Lampinen ◽  
Juliana Leding ◽  
Christopher S. Peters
Keyword(s):  
Structural Equation Modelling ◽  
Structural Equation ◽  
Equation Modelling ◽  
Weapon Focus ◽  
Focus Effect ◽  
Weapon Focus Effect

PENGARUH TANGGUNG JAWAB PIMPINAN DAN IKLIM DEMOKRASI TERHADAP PEMBENTUKAN ORGANISASI CERDAS DAN DAMPAKNYA TERHADAP SIKAP PROFESIONAL DOSEN

ALQALAM ◽  
2007 ◽  
Vol 24 (2) ◽  
pp. 178
Author(s):  
Tata Rosita
Keyword(s):  
Path Analysis ◽  
Structural Equation Modelling ◽  
Structural Equation ◽  
Equation Modelling

Tujuan pokok penelitian ini adalah untuk memperoleh bukti empirik mengenai pembentukan organisasi cerdas pada lembaga pendidikan tinggi. Paradigma baru organisasi adalah keharusan untuk menyesuaikan dengan lingkungan sehingga memerlukan perubahan melalui kepemimpinan dan demokratisasi. Lebih jauh, kita ingin melihat bagaimana pengaruh organisasi cerdas terhadap sikap profesional dosen.Penelitian ini dilaksanakan dengan menggunakan metode survei penjelasan pada Perguruan Tinggi Swasta di D KI Jakarta. Data yang dikumpulkan terdiri dari data sekunder yaitu melalui penyebaran kuesioner. Teknik Analisis data menggunakan  Structural Equation Modelling (SEM) dengan pendekatan Path Analysis (Analisis Jalur).Berdasarkan analisis dan pembahasan hasil penelitian ini, maka dapat disimpulkan beberapa hal sebagai berikut: (1) Tanggung jawab pimpinan memiliki pengaruh yang sangat signifikan terhadap organisasi cerdas, (2) Iklim demokrasi memiliki pengaruh yang signifikan terhadap organisasi cerdas, (3) Tanggung jawab pimpinan tidak memiliki pengaruh yang signifikan terhadap Iklim demokrasi, dan (4) Organisasi cerdas memiliki pengaruh yang signifikan terhadap sikap profesional.

PENTINGNYA KUALITAS PELAYANAN TERHADAP KEPUASAN DAN LOYALITAS PENGUNJUNG PERPUSTAKAAN DAERAH KABUPATEN SUMENEP

2015 ◽  
Vol 5 (2) ◽  
pp. 67
Author(s):  
Sayyida , ◽  
Bambang Hermanto ◽  
Edy Sugianto
Keyword(s):  
Structural Equation Modelling ◽  
Structural Equation ◽  
Equation Modelling ◽  
Key Word

Salah satu fungsi utama dari perpustakaan adalah pengemasan dan penyebaran informasi, bukanlah penciptaan informasi. Sehingga perpustakaan dituntut untuk memberikan layanan informasi yang lebih baik dan tepat guna. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kualitas pelayanan terhadap kepuasan dan loyalitas serta pengaruh dari kepuasan terhadap loyalitas pengunjung di perpustakaan Daerah Kabupaten Sumenep. Sampel yang diteliti sebanyak 200 orang yang terdiri dari Siswa, Mahasiswa dan Umum. Data dianalisis dengan menggunakan analisis structural equation modelling (SEM). Berdasarkan hasil analisis dapat disimpulkan bahwa semakin baik kualitas pelayanan, maka semakin meningkat kepuasan pengunjung serta pengunjung akan semakin royal terhadap perpustakaan Daerah Kabupaten Sumenep. Key Word :      Perpustakaan, Structural Equation Modelling (SEM), Kualitas Pelayanan, Kepuasan Dan Loyalitas

Faktor-Faktor Pengembangan Sistem Informasi Akademik Berbasis Web Pada Perguruan Tinggi Swasta Palembang

2018 ◽  
Vol 2 (1) ◽  
pp. 295-300
Author(s):  
Muhammad Soekarno Putra
Keyword(s):  
Structural Equation Modelling ◽  
Structural Equation ◽  
Equation Modelling

Salah satu pemanfaatan perkembangan teknologi informasi di dunia pendidikan di perguruan tinggi swasta (PTS) yaitu dengan memanfaatkan dan mengimplementasikan sistem informasi akademik (SIA) berbasis web. Penelitian ini bertujuan untuk meneliti kontribusi teknologi dan infrastruktur (TI), desain (DS), sumber daya manusia (SD) dan budaya (BD) dalam pengembangan SIA berbasis web pada PTS di Palembang. Metode penelitian yang digunakan adalah metode kuantitatif, sedangkan teknik pengumpulan data menggunakan metode angket. Metode analisa data pada penelitian ini menggunakan Structural Equation Modelling (SEM). Populasi dalam penelitian ini adalah PTS di Palembang yang memiliki SIA berbasis web yaitu Universitas Bina Darma dan STMIK Palcomtech. Sedangkan yang dijadikan responden yaitu mahasiswa, dosen dan staff. Hasil dari penelitian menunjukkan bahwa teknologi dan infrastruktur, desain, sumber daya manusia dan budaya berkontribusi terhadap pengembangan SIA berbasis web pada PTS di Palembang.

Investigating multidimensionality of language lateralisation in left and right handed adults: an update on Woodhead et al. 2019

2020 ◽  
Author(s):  
Zoe Victoria Joan Woodhead ◽  
Paul Andrew Thompson ◽  
Emma Karlsson ◽  
Dorothy Vera Margaret Bishop
Keyword(s):  
Transcranial Doppler ◽  
Structural Equation Modelling ◽  
Structural Equation ◽  
Doppler Sonography ◽  
Factor Model ◽  
Transcranial Doppler Sonography ◽  
Group Level ◽  
Equation Modelling ◽  
Left And Right ◽  
Functional Transcranial Doppler Sonography

A previous study we reported in this journal suggested that left and right handers may differ in their patterns of lateralisation for different language tasks. However, it had too few left handers (N=7) to reach any conclusions. For this update paper, further participants were added to the sample to create separate groups of left (N=31) and right handers (N=43). Two hypotheses were tested: 1) that lateralisation would be weaker at the group level in left than right handers; and 2) that left handers would show weaker covariance in lateralisation between tasks, supporting a two factor model.All participants performed the same protocol as in our previous paper: lateralisation was measured using functional transcranial Doppler sonography during six different language tasks, on two separate testing sessions. The results supported hypothesis 1, with significant differences in laterality between groups for four out of six tasks. For hypothesis 2, structural equation modelling showed that there was stronger evidence for a two factor model in left than right handers; furthermore, examination of the factor loadings suggested that the pattern of laterality across tasks may also differ between handedness groups. These results expand on what is known about the differences in laterality between left and right handers.

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