scholarly journals Metabolomics analysis of serum 25-hydroxy-vitamin D in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

2016 ◽  
Vol 45 (5) ◽  
pp. 1458-1468 ◽  
Author(s):  
Shakira M Nelson ◽  
Orestis A Panagiotou ◽  
Gabriella M Anic ◽  
Alison M Mondul ◽  
Satu Männistö ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cancer Prevention ◽  
Beta Carotene ◽  
Alpha Tocopherol ◽  
25 Hydroxy Vitamin D ◽  
Atbc Study ◽  
Metabolomics Analysis

scholarly journals Family history of prostate cancer and prostate cancer risk in the Alpha‐Tocopherol, Beta‐Carotene Cancer Prevention (ATBC) Study

2008 ◽  
Vol 123 (5) ◽  
pp. 1154-1159 ◽  
Author(s):  
Jiyoung Ahn ◽  
Roxana Moslehi ◽  
Stephanie J. Weinstein ◽  
Kirk Snyder ◽  
Jarmo Virtamo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Family History ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Prostate Cancer Risk ◽  
Beta Carotene ◽  
Alpha Tocopherol ◽  
History Of ◽  
Atbc Study

scholarly journals Vitamin E and the risk of pneumonia: using the I2 statistic to quantify heterogeneity within a controlled trial

2016 ◽  
Vol 116 (9) ◽  
pp. 1530-1536 ◽  
Author(s):  
Harri Hemilä
Keyword(s):  
Vitamin E ◽  
Cancer Prevention ◽  
Treatment Effect ◽  
Leisure Time ◽  
Controlled Trial ◽  
Beta Carotene ◽  
Alpha Tocopherol ◽  
Nutritional Epidemiology ◽  
Atbc Study ◽  
Vitamin E Supplementation

AbstractAnalyses in nutritional epidemiology usually assume a uniform effect of a nutrient. Previously, four subgroups of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of Finnish male smokers aged 50–69 years were identified in which vitamin E supplementation either significantly increased or decreased the risk of pneumonia. The purpose of this present study was to quantify the level of true heterogeneity in the effect of vitamin E on pneumonia incidence using the I2 statistic. The I2 value estimates the percentage of total variation across studies that is explained by true differences in the treatment effect rather than by chance, with a range from 0 to 100 %. The I2 statistic for the effect of vitamin E supplementation on pneumonia risk for five subgroups of the ATBC population was 89 % (95 % CI 78, 95 %), indicating that essentially all heterogeneity was true variation in vitamin E effect instead of chance variation. The I2 statistic for heterogeneity in vitamin E effects on pneumonia risk was 92 % (95 % CI 80, 97 %) for three other ATBC subgroups defined by smoking level and leisure-time exercise level. Vitamin E decreased pneumonia risk by 69 % among participants who had the least exposure to smoking and exercised during leisure time (7·6 % of the ATBC participants), and vitamin E increased pneumonia risk by 68 % among those who had the highest exposure to smoking and did not exercise (22 % of the ATBC participants). These findings refute there being a uniform effect of vitamin E supplementation on the risk of pneumonia.

Abstract 13: Telomere length and pancreatic cancer in the alpha-tocopherol beta-carotene cancer prevention (ATBC) study.

2012 ◽  
Vol 21 (11 Supplement) ◽  
pp. 13-13
Author(s):  
Shannon M. Lynch ◽  
Jacqueline M. Major ◽  
Richard Cawthon ◽  
Stephanie J. Weinstein ◽  
Jarmo Virtamo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Prevention ◽  
Telomere Length ◽  
Beta Carotene ◽  
Alpha Tocopherol ◽  
Atbc Study

scholarly journals Metabolomic analysis of prostate cancer risk in a prospective cohort: The alpha‐tocopherol, beta‐carotene cancer prevention (ATBC) study

2015 ◽  
Vol 137 (9) ◽  
pp. 2124-2132 ◽  
Author(s):  
Alison M. Mondul ◽  
Steven C. Moore ◽  
Stephanie J. Weinstein ◽  
Edward D. Karoly ◽  
Joshua N. Sampson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Prospective Cohort ◽  
Prostate Cancer Risk ◽  
Beta Carotene ◽  
Alpha Tocopherol ◽  
Metabolomic Analysis ◽  
Atbc Study

scholarly journals Metabolomic Profiling of Serum Retinol in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jiaqi Huang ◽  
Orestis A. Panagiotou ◽  
Gabriella M. Anic ◽  
Alison M. Mondul ◽  
Linda M. Liao ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Beta Carotene ◽  
Alpha Tocopherol ◽  
Serum Retinol ◽  
Metabolomic Profiling ◽  
Atbc Study

scholarly journals β-Carotene Supplementation and Lung Cancer Incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: The Role of Tar and Nicotine

2018 ◽  
Vol 21 (8) ◽  
pp. 1045-1050 ◽  
Author(s):  
Pooja Middha ◽  
Stephanie J Weinstein ◽  
Satu Männistö ◽  
Demetrius Albanes ◽  
Alison M Mondul
Keyword(s):  
Lung Cancer ◽  
Cancer Prevention ◽  
Cancer Incidence ◽  
Beta Carotene ◽  
Alpha Tocopherol ◽  
Lung Cancer Incidence ◽  
Nicotine Content ◽  
Increased Risk ◽  
Atbc Study ◽  
Β Carotene

Abstract Introduction The Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study demonstrated that β-carotene supplementation increases lung cancer incidence in smokers. Further, cigarettes with higher tar and nicotine content are associated with a higher risk of lung cancer. However, no studies have examined whether the increased risk associated with β-carotene supplementation in smokers varies by the tar or nicotine content of cigarettes. Methods The ATBC Study was a randomized, double-blind intervention trial conducted in southwest Finland. A total of 29 133 male smokers, aged 50–69 years, were enrolled and randomly assigned to one of four groups (α-tocopherol, β-carotene, both, or placebo). Cox proportional hazards models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of lung cancer risk by β-carotene trial assignment stratified by a priori categories of cigarette tar and nicotine content. Results The β-carotene supplementation group had significantly higher risk of developing lung cancer in all categories of tar content (yes vs. no β-carotene supplementation—ultralight cigarettes [≤7 mg tar]: HR = 1.31, 95% CI = 0.91 to 1.89; nonfiltered cigarettes [≥21 mg tar]: HR = 1.22, 95% CI = 0.91 to 1.64; p for interaction = .91). Similarly, there was no interaction with nicotine content (yes vs. no β-carotene supplementation—ventilated cigarettes [≤0.8 µg nicotine]: HR = 1.23, 95% CI = 0.98 to 1.54; nonfiltered cigarettes [≥1.3 µg nicotine]: HR = 1.22, 95% CI = 0.91 to 1.64; p for interaction = .83). Conclusion These findings support the conclusion that supplementation with β-carotene increases the risk of lung cancer in smokers regardless of the tar or nicotine content of cigarettes smoked. Our data suggest that all smokers should continue to avoid β-carotene supplementation. Implications Previous studies demonstrated that β-carotene supplementation increases risk of lung cancer in smokers. This study moves the field forward by examining the potential for modification of risk of lung cancer with different levels of tar and nicotine in cigarettes smoked, as interaction with carcinogens in these components of cigarette smoke is hypothesized to be the mechanism by which β-carotene increases risk. Our study provides evidence that the increased risk of lung cancer in smokers who take β-carotene supplements is not dependent upon the tar or nicotine level of cigarettes smoked and suggests that all smokers should continue to avoid β-carotene supplementation.

scholarly journals Glycaemic index database for the epidemiological Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

2008 ◽  
Vol 101 (09) ◽  
pp. 1400 ◽  
Author(s):  
Minna E. Similä ◽  
Liisa M. Valsta ◽  
Mikko J. Virtanen ◽  
Katja A. Hätönen ◽  
Jarmo Virtamo
Keyword(s):  
Cancer Prevention ◽  
Beta Carotene ◽  
Glycaemic Index ◽  
Alpha Tocopherol ◽  
Atbc Study
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