scholarly journals DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring

2015 ◽  
Vol 44 (4) ◽  
pp. 1224-1237 ◽  
Author(s):  
Leanne K Küpers ◽  
Xiaojing Xu ◽  
Soesma A Jankipersadsing ◽  
Ahmad Vaez ◽  
Sacha la Bastide-van Gemert ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Maternal smoking during pregnancy is associated with mitochondrial DNA methylation

2016 ◽  
Vol 2 (3) ◽  
pp. dvw020 ◽  
Author(s):  
David A. Armstrong ◽  
Benjamin B. Green ◽  
Bailey A. Blair ◽  
Dylan J. Guerin ◽  
Julia F. Litzky ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

2019 ◽  
Author(s):  
Todd M. Everson ◽  
Marta Vives-Usano ◽  
Emie Seyve ◽  
Andres Cardenas ◽  
Marina Lacasaña ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Birth Outcomes ◽  
Fetal Growth ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Growth Factor Signaling ◽  
Hormone Activity ◽  
Smoking During Pregnancy ◽  
Placental Function ◽  
Maternal Smoking During Pregnancy

AbstractMaternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. We meta-analyzed the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (7 studies, N=1700, 344 with any MSDP). We identified 1224 CpGs that were associated with MSDP, of which 341 associated with birth outcomes and 141 associated with gene expression. Only 6 of these CpGs were consistent with the findings from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP associated CpGs were enriched for growth-factor signaling, hormone activity, inflammation, and vascularization, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.

scholarly journals Identification of DNA Methylation Changes in Newborns Related to Maternal Smoking during Pregnancy

2014 ◽  
Vol 122 (10) ◽  
pp. 1147-1153 ◽  
Author(s):  
Christina A. Markunas ◽  
Zongli Xu ◽  
Sophia Harlid ◽  
Paul A. Wade ◽  
Rolv T. Lie ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Timing- and Dose-Specific Associations of Prenatal Smoke Exposure With Newborn DNA Methylation

2020 ◽  
Vol 22 (10) ◽  
pp. 1917-1922
Author(s):  
Giulietta S Monasso ◽  
Vincent W V Jaddoe ◽  
Johan C de Jongste ◽  
Liesbeth Duijts ◽  
Janine F Felix
Keyword(s):  
Dna Methylation ◽  
Early Pregnancy ◽  
Maternal Smoking ◽  
Third Trimester ◽  
Smoking During Pregnancy ◽  
The Third ◽  
Quitting Smoking ◽  
Maternal Smoking During Pregnancy ◽  
Paternal Smoking ◽  
In Pregnancy

Abstract Introduction Fetal changes in DNA methylation may underlie associations of maternal smoking during pregnancy with adverse outcomes in children. We examined critical periods and doses of maternal smoking during pregnancy in relation to newborn DNA methylation, and associations of paternal smoking with newborn DNA methylation. Aims and Methods This study was embedded in the Generation R Study, a population-based prospective cohort study from early pregnancy onwards. We assessed parental smoking during pregnancy using questionnaires. We analyzed associations of prenatal smoke exposure with newborn DNA methylation at 5915 known maternal smoking-related cytosine-phosphate-guanine sites (CpGs) in 1261 newborns using linear regression. Associations with false discovery rate-corrected p-values < .05 were taken forward. Results Sustained maternal smoking was associated with newborn DNA methylation at 1391 CpGs, compared with never smoking. Neither quitting smoking early in pregnancy nor former smoking was associated with DNA methylation, compared with never smoking. Among sustained smokers, smoking ≥5, compared with <5, cigarettes/d was associated with DNA methylation at seven CpGs. Paternal smoking was not associated with DNA methylation, independent of maternal smoking status. Conclusions Our results suggest that CpGs associated with sustained maternal smoking are not associated with maternal smoking earlier in pregnancy or with paternal smoking. Some of these CpGs show dose–response relationships with sustained maternal smoking. The third trimester may comprise a critical period for associations of smoking with newborn DNA methylation, or sustained smoking may reflect higher cumulative doses. Alternatively, maternal smoking limited to early pregnancy and paternal smoking may be associated with DNA methylation at specific other CpGs not studied here. Implications Our results suggest that quitting maternal smoking before the third trimester of pregnancy, and possibly lowering smoking dose, may prevent differential DNA methylation in the newborns at CpGs associated with sustained smoking. If the relevance of DNA methylation for clinical outcomes is established, these results may help in counseling parents-to-be about quitting smoking.

scholarly journals Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy

2016 ◽  
Vol 45 (5) ◽  
pp. 1644-1655 ◽  
Author(s):  
Eva Morales ◽  
Nadia Vilahur ◽  
Lucas A Salas ◽  
Valeria Motta ◽  
Mariana F Fernandez ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Human Placenta ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Genome Wide ◽  
Maternal Smoking During Pregnancy

scholarly journals Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Todd M. Everson ◽  
Marta Vives-Usano ◽  
Emie Seyve ◽  
Andres Cardenas ◽  
Marina Lacasaña ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Birth Outcomes ◽  
Fetal Growth ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Growth Factor Signaling ◽  
Environmental Response ◽  
Smoking During Pregnancy ◽  
Placental Function ◽  
Maternal Smoking During Pregnancy

AbstractMaternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.

scholarly journals 450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy

2012 ◽  
Vol 120 (10) ◽  
pp. 1425-1431 ◽  
Author(s):  
Bonnie R. Joubert ◽  
Siri E. Håberg ◽  
Roy M. Nilsen ◽  
Xuting Wang ◽  
Stein E. Vollset ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Maternal Smoking ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy
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