scholarly journals Authors' Response to: Alcohol imagery and branding, and age classification of films popular in the UK

2012 ◽  
Vol 41 (3) ◽  
pp. 887-888
Author(s):  
A. Lyons ◽  
A. McNeill ◽  
I. Gilmore ◽  
J. Britton
Keyword(s):  
2007 ◽  
Vol 11 (4) ◽  
pp. 1501-1513 ◽  
Author(s):  
M. K. Schneider ◽  
F. Brunner ◽  
J. M. Hollis ◽  
C. Stamm

Abstract. Predicting discharge in ungauged catchments or contaminant movement through soil requires knowledge of the distribution and spatial heterogeneity of hydrological soil properties. Because hydrological soil information is not available at a European scale, we reclassified the Soil Geographical Database of Europe (SGDBE) at 1:1 million in a hydrological manner by adopting the Hydrology Of Soil Types (HOST) system developed in the UK. The HOST classification describes dominant pathways of water movement through soil and was related to the base flow index (BFI) of a catchment (the long-term proportion of base flow on total stream flow). In the original UK study, a linear regression of the coverage of HOST classes in a catchment explained 79% of BFI variability. We found that a hydrological soil classification can be built based on the information present in the SGDBE. The reclassified SGDBE and the regression coefficients from the original UK study were used to predict BFIs for 103 catchments spread throughout Europe. The predicted BFI explained around 65% of the variability in measured BFI in catchments in Northern Europe, but the explained variance decreased from North to South. We therefore estimated new regression coefficients from the European discharge data and found that these were qualitatively similar to the original estimates from the UK. This suggests little variation across Europe in the hydrological effect of particular HOST classes, but decreasing influence of soil on BFI towards Southern Europe. Our preliminary study showed that pedological information is useful for characterising soil hydrology within Europe and the long-term discharge regime of catchments in Northern Europe. Based on these results, we draft a roadmap for a refined hydrological classification of European soils.


Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012919
Author(s):  
Yanjun Guo ◽  
Iyas Daghlas ◽  
Padhraig Gormley ◽  
Franco Giulianini ◽  
Paul M Ridker ◽  
...  

Background and Objective:To evaluate phenotypic and genetic relationships between migraine and lipoprotein subfractions.Methods:We evaluated phenotypic associations between migraine and 19 lipoprotein subfractions measures in the Women’s Genome Health Study (WGHS, N=22,788). We then investigated genetic relationships between these traits using summary statistics from the International Headache Genetics Consortium (IHGC) for migraine (Ncase=54,552, Ncontrol=297,970) and combined summary data for lipoprotein subfractions (N up to 47,713).Results:There was a significant phenotypic association (odds ratio=1.27 [95% confidence interval:1.12-1.44]) and a significant genetic correlation at 0.18 (P=0.001) between migraine and triglyceride-rich lipoproteins (TRLP) concentration but not for LDL or HDL subfractions. Mendelian randomization (MR) estimates were largely null implying that pleiotropy rather than causality underlies the genetic correlation between migraine and lipoprotein subfractions. Pleiotropy was further supported in cross-trait meta-analysis revealing significant shared signals at four loci (chr2p21 harboring THADA, chr5q13.3 harboring HMGCR, chr6q22.31 harboring HEY2, and chr7q11.23 harboring MLXIPL) between migraine and lipoprotein subfractions. Three of these loci were replicated for migraine (P<0.05) in a smaller sample from the UK Biobank. The shared signal at chr5q13.3 colocalized with expression of HMGCR, ANKDD1B, and COL4A3BP in multiple tissues.Conclusions:The current study supports the association between certain lipoprotein subfractions, especially for TRLP, and migraine in populations of European ancestry. The corresponding shared genetic components may be help identify potential targets for future migraine therapeutics.Classification of Evidence:This study provides Class I evidence that migraine is significantly associated with some lipoprotein subfractions.


Sociology ◽  
2013 ◽  
Vol 47 (5) ◽  
pp. 976-992 ◽  
Author(s):  
David Skinner

This article explores the place of ‘ethnicity’ in the operation, management and contestation of the UK National DNA Database (NDNAD). In doing so, it examines the limitations of bioethics as a response to political questions raised by the new genetics. The UK police forensic database has been racialised in a number of distinct ways: in the over-representation of black people in the database population; in the classification of all DNA profiles according to ‘ethnic appearance’; in the use of data for experiments to determine the ethnicity of crime scene DNA; and in the focus on ethnicity in public debate about the database. This racialisation presented potential problems of legitimacy for the NDNAD but, as the article shows, these have been partly neutralised through systems of ethico-political governance. In these systems of governance discussion of institutional racism has been postponed or displaced by other ways of talking about ethnicity and identity.


2020 ◽  
Vol 384 (2) ◽  
pp. 111-118
Author(s):  
Y. E. Putihin ◽  
Y. N. Akimova ◽  
N. V. Ostrovskaya ◽  
I. A. Manvelova ◽  
E. V. Negashev

International Accounting Practice Accounting is multifaceted and heterogeneous. First distinguish between international standards and national standards. National accounting standards for each country is being developed independently. The leading countries in the field of national accounting standards are the United Kingdom and the United States, which is determined by the role of these countries in international financial markets. In different countries, national accounting standards are called differently; in addition, various bodies are involved in their development: in some these are state bodies, in other countries professional organizations. International accounting standards are implemented and developed at 2 levels: international, global and regional. In the regional aspect, the main role belongs to the EU Accounting Commission, which regulates these matters in the EU countries. World standards are developed by several organizations: International Federation of Accountants, Committee on International Accounting Standards, Intergovernmental Group of Experts on International Standards Reporting and Accounting Center for Transnational United Nations Corporation, Economic development and cooperation. There is a great variety of accounting systems around the world. The differences between them are explained mainly by the different business environments in which they operate. Among many classifications, which are based on various principles, two main classifications can be distinguished. The first one is based on the “geographical” principle, i.e.: the UK-US system, the Continental system, the Latin American system. In the second classification, systems are clustered based on their typical properties and hierarchy. The upper level defines the objectives that the accounting system focuses on. Next, systems are rated based on whether the state insists on applying the theoretical approach or the actual legislative requirements and business needs. It might be difficult to classify a system as belonging to a specific group if the country’s accounting system is unstable. Thus, in the 60s of the 20th century, New Zealand started to separate from the UK, although many provisions of its accounting system were taken directly from the standards developed by the English Institute of Financial Accountants. In view of the existing challenges and various approaches to the classification of national accounting systems, the importance of such classification can hardly be overestimated. The proximity of national accounting systems in countries that belong to the same model suggests the possibility of harmonization of accounting principles at the international level. Based on the above: - the possibility of grouping national accounting systems into clusters makes it possible to level out the differences between them during standardization; - the convergence of economies of different countries due to the globalization of the world economy contributes to the unification of accounting principles at the global level.


Author(s):  
Ashley Bond ◽  
Michael D Burkitt ◽  
Trevor Cox ◽  
Howard L. Smart ◽  
Chris Probert ◽  
...  

Background: In the UK, the majority of diagnostic upper gastrointestinal (UGI) endoscopies are a result of direct-to-test referral from the primary care physician. The diagnostic yield of these tests is relatively low, and the burden high on endoscopy services. Dual-focus magnification, high-definition endoscopy is expected to improve detection and classification of UGI mucosal lesions and also help minimize biopsies by allowing better targeting.Methods: This is a retrospective study of patients attending for direct-to-test UGI endoscopy from January 2015 to June 2015. The primary outcome of interest was the identification of significant pathology. Detection of significant pathology was modelled using logistic regression.Results: 500 procedures were included. The mean age of patients was 61.5 (±15.6) years; 60.8% of patients were female. Ninety-four gastroscopies were performed using dual-focus magnification high-definition endoscopy. Increasing age, male gender, type of endoscope, and type of operator were all identified as significant factors influencing the odds of detecting significant mucosal pathology. Use of dual-focus magnification, high-definition endoscopy was associated with an odds ratio of 1.87 (95%CI 1.11-3.12) favouring the detection of significant pathology. Subsequent analysis suggested that the increased detection of pathology during dual-focus magnification, high-definition endoscopy also influenced patient follow-up and led to a 3.0 fold (p=0.04) increase in the proportion of patients entered into an UGI endoscopic surveillance program.Conclusion: Dual-focus magnification, high-definition endoscopy improved the diagnostic yield for significant mucosal pathology in patients referred for direct-to-test endoscopy. If this finding is recapitulated elsewhere it will have substantial impact on the provision of UGI endoscopic services.


2007 ◽  
Vol 53 ◽  
pp. 77-92
Author(s):  
R. F. Sellers

John Brooksby was an outstanding veterinary virologist, who worked at the Animal Virus Diseases Research Institute, Pirbright, for 40 years, for 16 of which he was Director of the Institute. He will be remembered for his contributions to the diagnosis of foot-and-mouth disease, for his discovery of four new types, for the classification of subtypes and for fundamental studies of the virus. As Deputy Director and Director he was responsible for programmes on fundamental investigations of foot–and–mouth disease virus and other viruses exotic to the UK and for the application of the results both in the UK and worldwide. His advice on the distribution and the control of foot–and–mouth disease was sought by international organizations and by individual countries and was responsible for reducing the risk of spread of disease.


1988 ◽  
Vol 153 (S3) ◽  
pp. 11-15 ◽  
Author(s):  
P. Pichot

The publication by the American Psychiatric Association in 1980 of the Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM-III) - a text whose influence has been felt throughout the entire world and whose system of classification, particularly within the context of depressive disorders, has now been adopted by the majority of research work, no matter in what country it is implemented or published - has given the impression that an ‘American perspective’ has been substituted for the ‘European perspective’ that was predominant up to that point. However, this is a simplistic view of a complex history. Certainly, the basic methods of DSM-III originated from within those traditions which are particularly rooted in the USA, such as the quantitative approach to diagnostic criteria; these derive in the final analysis from the ‘statistical psychology’ devised by James McKeen Cattell at the University of Pennsylvania in 1887, and subsequently taught by him at Columbia University. But even among those factors which appear to be characteristically American, European origins can be detected: when he was in London, Cattell was the pupil of Galton, the founder of biometry. Furthermore, there has never existed in Europe any unanimity of opinion with regard to the problems of nosology: concepts supported in the German-speaking countries, in France, in the UK, or in the Scandinavian countries have only been partially adopted elsewhere and occasionally have remained specific to their national tradition. This paper will examine two of the fundamental points in the classification of depression which are linked to European perspectives - the notion of affective disorder and the endogenous/non-endogenous dichotomy - and will discuss the present situation created by the discordance which exists between the European and American approaches.


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