scholarly journals Juvenile delinquency, social background and suicide--a Swedish national cohort study of 992 881 young adults

2011 ◽  
Vol 40 (6) ◽  
pp. 1585-1592 ◽  
Author(s):  
E. Bjorkenstam ◽  
C. Bjorkenstam ◽  
B. Vinnerljung ◽  
J. Hallqvist ◽  
R. Ljung
Keyword(s):  
Young Adults ◽  
Cohort Study ◽  
Juvenile Delinquency ◽  
Social Background ◽  
National Cohort

Dental healthcare utilisation among young adults who were in societal out-of-home care as children: A Swedish National Cohort Study

2018 ◽  
Vol 27 (4) ◽  
pp. 325-336 ◽  
Author(s):  
Marie Berlin ◽  
Tita Mensah ◽  
Frida Lundgren ◽  
Gunilla Klingberg ◽  
Anders Hjern ◽  
...  
Keyword(s):  
Young Adults ◽  
Cohort Study ◽  
Home Care ◽  
Healthcare Utilisation ◽  
Out Of Home Care ◽  
National Cohort

scholarly journals Age Does Matter in Adolescents and Young Adults versus Older Adults with Advanced Melanoma; A National Cohort Study Comparing Tumor Characteristics, Treatment Pattern, Toxicity and Response

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2072 ◽  
Author(s):  
Monique K. van der Kooij ◽  
Marjolein J.A.L. Wetzels ◽  
Maureen J.B. Aarts ◽  
Franchette W.P.J. van den Berkmortel ◽  
Christian U. Blank ◽  
...  
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Cohort Study ◽  
Group Performance ◽  
Advanced Melanoma ◽  
Adolescents And Young Adults ◽  
First Line ◽  
National Cohort ◽  
Baseline Characteristics ◽  
Grade 3

Cutaneous melanoma is a common type of cancer in Adolescents and Young Adults (AYAs, 15–39 years of age). However, AYAs are underrepresented in clinical trials investigating new therapies and the outcomes from these therapies for AYAs are therefore unclear. Using prospectively collected nation-wide data from the Dutch Melanoma Treatment Registry (DMTR), we compared baseline characteristics, mutational profiles, treatment strategies, grade 3–4 adverse events (AEs), responses and outcomes in AYAs (n = 210) and older adults (n = 3775) who were diagnosed with advanced melanoma between July 2013 and July 2018. Compared to older adults, AYAs were more frequently female (51% versus 40%, p = 0.001), and had a better Eastern Cooperative Oncology Group performance status (ECOG 0 in 54% versus 45%, p = 0.004). BRAF and NRAS mutations were age dependent, with more BRAF V600 mutations in AYAs (68% versus 46%) and more NRAS mutations in older adults (13% versus 21%), p < 0.001. This finding translated in distinct first-line treatment patterns, where AYAs received more initial targeted therapy. Overall, grade 3–4 AE percentages following first-line systemic treatment were similar for AYAs and older adults; anti-PD-1 (7% versus 14%, p = 0.25), anti-CTLA-4 (16% versus 33%, p = 0.12), anti-PD-1 + anti-CTLA-4 (67% versus 56%, p = 0.34) and BRAF/MEK-inhibition (14% versus 23%, p = 0.06). Following anti-CTLA-4 treatment, no AYAs experienced a grade 3–4 colitis, while 17% of the older adults did (p = 0.046). There was no difference in response to treatment between AYAs and older adults. The longer overall survival observed in AYAs (hazard ratio (HR) 0.7; 95% CI 0.6–0.8) was explained by the increased cumulative incidence of non-melanoma related deaths in older adults (sub-distribution HR 2.8; 95% CI 1.5–4.9), calculated by competing risk analysis. The results of our national cohort study show that baseline characteristics and mutational profiles differ between AYAs and older adults with advanced melanoma, leading to different treatment choices made in daily practice. Once treatment is initiated, AYAs and older adults show similar tumor responses and melanoma-specific survival.

Preterm Infants as Young Adults: A Swedish National Cohort Study

PEDIATRICS ◽  
2007 ◽  
Vol 120 (1) ◽  
pp. 70-77 ◽  
Author(s):  
K. Lindstrom ◽  
B. Winbladh ◽  
B. Haglund ◽  
A. Hjern
Keyword(s):  
Young Adults ◽  
Cohort Study ◽  
Preterm Infants ◽  
National Cohort
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