scholarly journals Commentary: Effects of diagnostic thresholds and research vs service and administrative diagnosis on autism prevalence

2009 ◽  
Vol 38 (5) ◽  
pp. 1234-1238 ◽  
Author(s):  
T. Charman ◽  
A. Pickles ◽  
S. Chandler ◽  
L. Wing ◽  
S. Bryson ◽  
...  
Keyword(s):  
Diagnostic Thresholds ◽  
Autism Prevalence

84-OR: Index60 and 2-Hour Glucose Diagnostic Thresholds: Comparison of Type 1 Diabetes (T1D) Marker Profiles

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 84-OR
Author(s):  
MARIA JOSE REDONDO ◽  
BRANDON M. NATHAN ◽  
LAURA E. BOCCHINO ◽  
SUSAN GEYER ◽  
LAURA M. JACOBSEN ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diagnostic Thresholds

scholarly journals The diagnostic threshold of Cornell assessment of pediatric delirium in detection of postoperative delirium in pediatric surgical patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hong Hong ◽  
Chao Guo ◽  
Zhi-Hua Liu ◽  
Bo-Jie Wang ◽  
Shu-Zhe Zhou ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Assessment Instrument ◽  
Surgical Patients ◽  
Reference Standard ◽  
Diagnostic And Statistical Manual ◽  
Diagnostic Thresholds ◽  
Diagnostic Threshold ◽  
Effective Instrument ◽  
Sensitivity Specificity ◽  
Selective Surgery

Abstract Background Cornell assessment of pediatric delirium (CAPD) showed advantage in diagnosis of pediatric delirium in Chinese critically ill patients. But its performance in surgical patients is still unclear. The present study was designed to validate the diagnostic performance of CAPD in surgical pediatric patients. Methods This is a prospective validation study. Pediatric patients who underwent selective surgery and general anesthesia were enrolled. Primary outcome was the incidence of delirium within postoperative three days. CAPD Chinese version was used to evaluate if the patient had delirium one time per day. At the meantime, a psychiatrist employed Diagnostic and Statistical Manual of Mental Disorders fifth edition to diagnose delirium, which was the “gold standard”, and the result was considered as reference standard. Sensitivity, specificity and area under receiver operating characteristic (ROC) curve were calculated to investigate the performance of CAPD. Results A total of 170 patients were enrolled. Median age was 4 years old. As diagnosed by psychiatrist, 23 (13.5 %) patients experienced at least one episode of delirium during the follow-up period. When diagnostic threshold was set at 9, CAPD showed the optimal sensitivity (87.0 %, 95 %CI 65.3 %-96.6 %) and specificity (98.0 %, 95 %CI 93.7 %-99.5 %) in comparison with other diagnostic thresholds. ROC analysis showed that CAPD was a good delirium assessment instrument with area under curve of 0.911 (95 % CI 0.812 to 1.000, P < 0.001). Agreement between CAPD and reference standard was 0.849 (Kappa coefficient, P < 0.001). Conclusions This study found that Cornell assessment of pediatric delirium could be used as an effective instrument in diagnosis of delirium in pediatric surgical patients. Trial registration www.chictr.org.cn Identifier: ChiCTR-DDD-17,012,231, August 3, 2017.

ESR and CRP Diagnostic Thresholds for Prosthetic Joint Infection in Hip Hemiarthroplasty

2020 ◽  
Vol 4 (04) ◽  
pp. 187-192
Author(s):  
Jared A. Warren ◽  
Oliver Scotting ◽  
Hiba K. Anis ◽  
James Bircher ◽  
Alison K. Klika ◽  
...  
Keyword(s):  
Prosthetic Joint Infection ◽  
Joint Infection ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Musculoskeletal Infection ◽  
Hip Hemiarthroplasty ◽  
Diagnostic Thresholds ◽  
Diagnostic Threshold ◽  
Prosthetic Joint ◽  
The Mean

AbstractDiagnostic thresholds used to standardize the definition for prosthetic joint infection (PJI) have largely focused on total joint arthroplasty (TJA). Established PJI thresholds exist for serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in TJA; however, they do not exist for revision hip hemiarthroplasty (rHHA). The purpose of this study was to establish thresholds for (1) ESR and (2) CRP to diagnose PJI in rHHA. Data were collected on a prospective cohort of 69 rHHA patients undergoing orthopaedic surgery between 1/2017 and 2/2019 in a single health care system. Procedures were categorized as septic or aseptic revisions using Musculoskeletal Infection Society (MSIS) criteria (2013). There were 44 ESRs (n = 28 aseptic, n = 16 septic) and 46 CRPs (n = 29 aseptic, n = 17 septic) available for analysis. Two tailed t-tests were performed to compare the mean ESR and CRP in aseptic and septic cases. Receiver operator characteristic (ROC) curves were generated to obtain diagnostic cutoff thresholds using the Youden's Index (J) for ESR and CRP. The mean ESR was 50.3 ± 30.6 mm/h versus 15.4 ± 17.7 mm/h (p < 0.001), while the mean CRP was 29.9 ± 24.8 mg/L versus 4.1 ± 8.2 mg/L (p < 0.001) for septic and aseptic revisions, respectively. The diagnostic threshold for PJI determined by the ROC curve was 44 mm/h for ESR (sensitivity = 56.3%; specificity = 100.0%; J = 0.563; area under the curve (AUC) = 0.845), while it was 12.5 mg/L for CRP (sensitivity = 70.6%; specificity = 96.6%; J = 0.672; AUC = 0.896). For patients with HHA, an ESR of 44 mm/h was and a CRP of 12.5 mg/L was highly specific for PJI. The thresholds are similar to the MSIS thresholds currently published. Larger prospective trials are needed to establish more robust and conclusive diagnostic criteria for PJI in HHA, including investigations not only of ESR and CRP but synovial white blood cell count and synovial polymorphonuclear leukocytes % as well.

Bravo Catheter-Free pH Monitoring: Normal Values, Concordance, Optimal Diagnostic Thresholds, and Accuracy

2009 ◽  
Vol 7 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Shahin Ayazi ◽  
John C. Lipham ◽  
Giuseppe Portale ◽  
Christian G. Peyre ◽  
Christopher G. Streets ◽  
...  
Keyword(s):  
Normal Values ◽  
Ph Monitoring ◽  
Diagnostic Thresholds
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