scholarly journals Commentary on: “The contribution of tissue-specific BMI-associated gene sets to cardiometabolic disease risk: a Mendelian randomization study”

2020 ◽  
Vol 49 (4) ◽  
pp. 1257-1258
Author(s):  
Zoltán Kutalik
Keyword(s):  
Mendelian Randomization ◽  
Disease Risk ◽  
Cardiometabolic Disease ◽  
Tissue Specific ◽  
Gene Sets ◽  
Cardiometabolic Disease Risk

scholarly journals The Contribution Of Tissue-Specific Bmi-Associated Gene Sets To Cardiometabolic Disease Risk Using Mendelian Randomization

2019 ◽  
Vol 287 ◽  
pp. e69-e70
Author(s):  
I. Verkouter ◽  
R. de Mutsert ◽  
R. Smit ◽  
F. Rosendaal ◽  
D. van Heemst ◽  
...  
Keyword(s):  
Mendelian Randomization ◽  
Disease Risk ◽  
Cardiometabolic Disease ◽  
Tissue Specific ◽  
Gene Sets ◽  
Cardiometabolic Disease Risk

scholarly journals The contribution of tissue-grouped BMI-associated gene sets to cardiometabolic-disease risk: a Mendelian randomization study

2020 ◽  
Vol 49 (4) ◽  
pp. 1246-1256
Author(s):  
Inge Verkouter ◽  
Renée de Mutsert ◽  
Roelof A J Smit ◽  
Stella Trompet ◽  
Frits R Rosendaal ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Mendelian Randomization ◽  
Disease Risk ◽  
Expression Profiles ◽  
Association Studies ◽  
Tissue Expression ◽  
Cardiometabolic Disease ◽  
Genome Wide Association Studies ◽  
Gene Sets ◽  
Artery Disease

Abstract Background Body mass index (BMI)-associated loci are used to explore the effects of obesity using Mendelian randomization (MR), but the contribution of individual tissues to risks remains unknown. We aimed to identify tissue-grouped pathways of BMI-associated loci and relate these to cardiometabolic disease using MR analyses. Methods Using Genotype-Tissue Expression (GTEx) data, we performed overrepresentation tests to identify tissue-grouped gene sets based on mRNA-expression profiles from 634 previously published BMI-associated loci. We conducted two-sample MR with inverse-variance-weighted methods, to examine associations between tissue-grouped BMI-associated genetic instruments and type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD), with use of summary-level data from published genome-wide association studies (T2DM: 74 124 cases, 824 006 controls; CAD: 60 801 cases, 123 504 controls). Additionally, we performed MR analyses on T2DM and CAD using randomly sampled sets of 100 or 200 BMI-associated genetic variants. Results We identified 17 partly overlapping tissue-grouped gene sets, of which 12 were brain areas, where BMI-associated genes were differentially expressed. In tissue-grouped MR analyses, all gene sets were similarly associated with increased risks of T2DM and CAD. MR analyses with randomly sampled genetic variants on T2DM and CAD resulted in a distribution of effect estimates similar to tissue-grouped gene sets. Conclusions Overrepresentation tests revealed differential expression of BMI-associated genes in 17 different tissues. However, with our biology-based approach using tissue-grouped MR analyses, we did not identify different risks of T2DM or CAD for the BMI-associated gene sets, which was reflected by similar effect estimates obtained by randomly sampled gene sets.

scholarly journals Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors – ERRATUM

2019 ◽  
Vol 49 (10) ◽  
pp. 1758-1758
Author(s):  
Ragni H. Mørch ◽  
Ingrid Dieset ◽  
Ann Færden ◽  
Elina J. Reponen ◽  
Sigrun Hope ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mental Disorders ◽  
Inflammatory Markers ◽  
Disease Risk ◽  
Cardiometabolic Disease ◽  
Severe Mental Disorders ◽  
Cardiometabolic Disease Risk

scholarly journals Distinct phenotypic characteristics of normal-weight adults at risk of developing cardiovascular and metabolic diseases

2020 ◽  
Vol 112 (4) ◽  
pp. 967-978
Author(s):  
Abishek Stanley ◽  
John Schuna ◽  
Shengping Yang ◽  
Samantha Kennedy ◽  
Moonseong Heo ◽  
...  
Keyword(s):  
Health Risk ◽  
Body Shape ◽  
Metabolic Diseases ◽  
Disease Risk ◽  
White Men ◽  
Normal Weight ◽  
Cardiometabolic Disease ◽  
Men And Women ◽  
Distinct Phenotype ◽  
Cardiometabolic Disease Risk

ABSTRACT Background The normal-weight BMI range (18.5–24.9 kg/m2) includes adults with body shape and cardiometabolic disease risk features of excess adiposity, although a distinct phenotype developed on a large and diverse sample is lacking. Objective To identify demographic, behavioral, body composition, and health-risk biomarker characteristics of people in the normal-weight BMI range who are at increased risk of developing cardiovascular and metabolic diseases based on body shape. Methods Six nationally representative waist circumference index (WCI, weight/height0.5) prediction formulas, with BMI and age as covariates, were developed using data from 17,359 non-Hispanic (NH) white, NH black, and Mexican-American NHANES 1999–2006 participants. These equations were then used to predict WCI in 5594 NHANES participants whose BMI was within the normal weight range. Men and women in each race/Hispanic-origin group were then separated into high, medium, and low tertiles based on the difference (residual) between measured and predicted WCI. Characteristics were compared across tertiles; P values for significance were adjusted for multiple comparisons. Results Men and women in the high WCI residual tertile, relative to their BMI and age-equivalent counterparts in the low tertile, had significantly lower activity levels; higher percent trunk and total body fat (e.g. NH white men, X ± SE, 25.3 ± 0.2% compared with 20.4 ± 0.2%); lower percent appendicular lean mass (skeletal muscle) and bone mineral content; and higher plasma insulin and triglycerides, higher homeostatic model assessment of insulin resistance (e.g. NH white men, 1.45 ± 0.07 compared with 1.08 ± 0.06), and lower plasma HDL cholesterol. Percent leg fat was also significantly higher in men but lower in women. Similar patterns of variable statistical significance were present within sex and race/ethnic groups. Conclusions Cardiometabolic disease risk related to body shape in people who are normal weight according to BMI is characterized by a distinct phenotype that includes potentially modifiable behavioral health risk factors.

Establishing A Step Per Day to Cardiometabolic Disease Risk Factor Dose-response

2010 ◽  
Vol 42 ◽  
pp. 253
Author(s):  
Shawn S. Rockey ◽  
Christopher M. Dorozynski ◽  
Steven Bischoff ◽  
Derek T. Smith
Keyword(s):  
Risk Factor ◽  
Dose Response ◽  
Disease Risk ◽  
Cardiometabolic Disease ◽  
Disease Risk Factor ◽  
Cardiometabolic Disease Risk

scholarly journals Hepatic fibrosis associates with multiple cardiometabolic disease risk factors: The Framingham Heart Study

Hepatology ◽  
2020 ◽  
Author(s):  
Michelle T. Long ◽  
Xiaoyu Zhang ◽  
Hanfei Xu ◽  
Ching‐Ti Liu ◽  
Kathleen E. Corey ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatic Fibrosis ◽  
Framingham Heart Study ◽  
Disease Risk ◽  
Cardiometabolic Disease ◽  
Heart Study ◽  
Cardiometabolic Disease Risk
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