Characteristics of Non-Insulin-Dependent Diabetes Mellitus in Elderly Men: Effect Modification by Family History

1996 ◽  
Vol 25 (2) ◽  
pp. 394-402 ◽  
Author(s):  
JOLANDA M A BOER ◽  
EDITH J M FESKENS ◽  
DAAN KROMHOUT
Keyword(s):  
Diabetes Mellitus ◽  
Family History ◽  
Insulin Dependent Diabetes Mellitus ◽  
Effect Modification ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Elderly Men ◽  
Insulin Dependent

Prospective Study of Small LDLs as a Risk Factor for Non–Insulin Dependent Diabetes Mellitus in Elderly Men and Women

Circulation ◽  
1995 ◽  
Vol 92 (7) ◽  
pp. 1770-1778 ◽  
Author(s):  
Melissa A. Austin ◽  
Leena Mykkänen ◽  
Johanna Kuusisto ◽  
Karen L. Edwards ◽  
Carrie Nelson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factor ◽  
Prospective Study ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Elderly Men ◽  
Men And Women ◽  
Insulin Dependent

Increased circulating leptin concentrations in insulin-resistant first-degree relatives of patients with non-insulin-dependent diabetes mellitus: relationship to body composition and insulin sensitivity but not to family history of non-insulin-dependent diabetes mellitus

1997 ◽  
Vol 136 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Birgit Nyholm ◽  
Sanne Fisker ◽  
Sten Lund ◽  
Niels Møller ◽  
Ole Schmitz
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Family History ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Serum Leptin ◽  
Percentage Body Fat ◽  
History Of ◽  
Insulin Dependent

Abstract Objective: To explore a possible association between serum concentration of leptin, insulin sensitivity and non-insulin-dependent diabetes mellitus (NIDDM). Design: Forty first-degree relatives of NIDDM patients and 35 control subjects matched for age, gender and body mass index underwent a hyperinsulinaemic (insulin infusion rate 0·6 mU/kg per min) euglycaemic clamp combined with indirect calorimetry. Serum leptin was measured in fasting blood samples obtained before the clamp. Results: All subjects had a normal oral glucose tolerance test. Insulin-stimulated glucose uptake (M) was decreased in the relatives compared with the control subjects (4·58 ± 0·27 versus 606 ± 0·25 mg/kg per min, P < 0·001). Conversely, serum leptin was increased in the relatives (9·6·/÷ 1·1 versus 6·1·/÷ 1·2 ng/ml (geometric mean·/÷ antilog s.e.m.). P < 0·05). A positive correlation was observed between circulating levels of leptin and percentage body fat (P < 0·001) and inverse correlations were found between leptin, M (P < 0·01), maximal aerobic capacity (VO2 max) (P < 0·01), and energy expenditure (P ≤ 0·01) in both groups. In multiple linear regression analysis, percentage body fat, gender and M significantly determined the level of leptin (r2 = 0·71, P < 0·001) whereas family history of NIDDM and VO2 max did not. Conclusion: Serum leptin is increased in insulin-resistant offspring of NIDDM patients. The association between leptin, anthropometric measures and insulin sensitivity is, however, comparable with that of a control group. The increased concentrations of serum leptin in the relatives appear to be associated with the insulin resistance, but not with a family history of NIDDM. European Journal of Endocrinology 136 173–179

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