Exact Confidence Interval of the SMR Based on Prevalence Data

1994 ◽  
Vol 23 (2) ◽  
pp. 428-429 ◽  
Author(s):  
JAMES LEE
Keyword(s):  
Confidence Interval ◽  
Prevalence Data ◽  
Exact Confidence Interval

Phase II study of vinorelbine in patients with pretreated advanced ovarian cancer: activity in platinum-resistant disease.

1996 ◽  
Vol 14 (9) ◽  
pp. 2546-2551 ◽  
Author(s):  
E Bajetta ◽  
A Di Leo ◽  
L Biganzoli ◽  
L Mariani ◽  
F Cappuzzo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Confidence Interval ◽  
Cancer Patients ◽  
Response Rate ◽  
Advanced Ovarian Cancer ◽  
Dose Intensity ◽  
Ca 125 ◽  
Resistant Disease ◽  
Platinum Resistant ◽  
Exact Confidence Interval

PURPOSE The aim of the study was to evaluate the activity of vinorelbine (VNLB) in a population of advanced ovarian cancer patients, with particular attention to defining its role in platinum-resistant disease. PATIENTS AND METHODS Thirty-three patients were recruited and treated with VNLB 25 mg/m2 intravenously (IV) weekly. the median age was 53 years, performance status 0 to 2, and number of previous chemotherapy regimens two (range, one to five). Twenty-four patients were platinum-resistant; the remaining nine either were platinum-sensitive (four cases) or had undetermined sensitivity (five cases). RESULTS The mean delivered dose-intensity of VNLB was 67% of the planned level, because 60% of the cycles were delayed due to neutropenia or anemia. Four partial responses (PRs) and one complete response (CR) were observed, for an overall response rate of 15% (95% exact confidence interval, 5.1% to 31.9%). All the responses occurred in the subgroup of 24 platinum-resistant cases, in whom the response rate was 21% (95% exact confidence interval, 7.1% to 42.1%). Seven patients became stabilized on VNLB, and 27% of the cases showed a reduction in serum cancer antigen 125 (CA 125) levels. G3/G4 side effects consisted of neutropenia, anemia, and worsening of preexisting peripheral neuropathy. No treatment-related deaths occurred. CONCLUSION VNLB led to a 21% response rate in the population of heavily pretreated and platinum-resistant ovarian cancer patients. Further studies of VNLB alone or in combination with taxanes are warranted in patients with less pretreatment.

Sample Size Requirements for Testing and Estimating Coefficient Alpha

2002 ◽  
Vol 27 (4) ◽  
pp. 335-340 ◽  
Author(s):  
Douglas G. Bonett
Keyword(s):  
Confidence Interval ◽  
Sample Size ◽  
Closed Form ◽  
Coefficient Alpha ◽  
Exact Test ◽  
Exact Confidence Interval

An approximate test and confidence interval for coefficient alpha are derived. The approximate test and confidence interval are then used to derive closed-form sample size formulas. The sample size formulas can be used to determine the sample size needed to test coefficient alpha with desired power or to estimate coefficient alpha with desired precision. The sample size formulas closely approximate the sample size requirements for an exact confidence interval or an exact test.

Prevalence of Verotoxigenic Escherichia coli O157:H7 in Fecal and Ear Samples from Slaughtered Cattle in Sweden

2009 ◽  
Vol 72 (8) ◽  
pp. 1709-1712 ◽  
Author(s):  
SOFIA BOQVIST ◽  
ANNA ASPAN ◽  
ERIK ERIKSSON
Keyword(s):  
Escherichia Coli ◽  
Confidence Interval ◽  
Age Groups ◽  
Prevalence Data ◽  
Adult Cattle ◽  
Young Stock ◽  
Fecal Samples ◽  
Age Variations ◽  
Monitoring Study ◽  
Carcass Contamination

A national verotoxigenic Escherichia coli (VTEC) O157:H7 monitoring study was carried out among cattle at slaughter in Sweden during 2005 and 2006. Sixty (3.4%; 95% confidence interval, 3.3 to 3.5%) of 1,758 fecal samples collected and 54 (12%; 95% confidence interval, 11.9 to 12.4 %) of 446 ear samples tested positive for VTEC O157:H7. Ear samples were included to evaluate whether they could be used to assess general VTEC O157:H7 contamination at slaughter. The respective prevalences of positive fecal and ear samples were 16 and 21% for older calves, 3.5 and 10% for young stock, and 1.6 and 12% for adult cattle. There were significant differences between the age groups for the fecal samples, but not for the ear samples. It could be that ear samples are less subject to age variations due to environmental factors, or perhaps this observation was due to fewer ear samples being collected in this study. Within the age groups, the prevalence of VTEC O157:H7–positive ear samples was significantly higher than that of fecal samples for young stock and adult cattle. Furthermore, the prevalence of positive ear samples fluctuated more widely throughout the year than that of positive fecal samples. The fecal prevalence data can be used as baseline data against which future intervention strategies can be evaluated, and the ear samples can be used as an indicator of environmental contamination. The results of the ear samples are too limited to determine if they can be used to detect hide contamination and risk of carcass contamination.

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