Metastatic Crohn’s Disease of the Aortic Valve Resulting in Severe Aortic Insufficiency, Non-infective Endocarditis, and Pericarditis

2019 ◽  
Vol 25 (10) ◽  
pp. e117-e118
Author(s):  
Neasa Mc Gettigan ◽  
Margaret Sheehan ◽  
Eoin Slattery
Keyword(s):  
Crohn’S Disease ◽  
Infective Endocarditis ◽  
Aortic Valve ◽  
Crohn's Disease ◽  
Aortic Insufficiency ◽  
Metastatic Crohn's Disease

scholarly journals 696. Bartonella quintana Endocarditis, A Case Series

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S400-S400
Author(s):  
Thomas D Dieringer ◽  
Glen Huang ◽  
Paul R Allyn ◽  
Jeffrey Klausner
Keyword(s):  
Renal Failure ◽  
Infective Endocarditis ◽  
Los Angeles ◽  
Aortic Valve ◽  
Literature Review ◽  
Case Series ◽  
The United States ◽  
Aortic Insufficiency ◽  
Homeless Population ◽  
Bartonella Quintana

Abstract Background Homelessness has been a growing issue in the United States and worldwide. Bartonella quintana, the causative agent of “Trench fever”, is a well known illness among homeless populations in urban centers. While many cases of B. quintana are self limited, the disease can have advanced presentations including endocarditis. We present a short case series of three cases of B. quintana infective endocarditis (IE) in homeless individuals in Los Angeles and review the literature of cases of B. quintana IE in the homeless population. Methods Here we report three cases of B. quintana IE encountered in homeless individuals at the University of California, Los Angeles (UCLA) hospital system. A literature review was also conducted. PubMed was searched for published cases of human IE secondary to B. quintana in homeless individuals. Results All three patients were male with ages ranging from 39 to 57 years old with a history of homelessness and alcohol use. Presentations were subacute to chronic in nature consisting of constitutional symptoms as well as a range of symptoms corresponding with heart and renal failure. Each patient was found to have varying degrees of aortic insufficiency with either identified aortic valve vegetation or valvular thickening. Diagnosis was made with a combination of Bartonella serologies and whole genome sequencing PCR. All three patient’s courses were complicated by renal failure at varying points limiting the use of gentamicin for the full treatment course. Two patients ultimately underwent aortic valve replacement due to severe aortic insufficiency and completed therapy with doxycycline and rifampin. A single patient was discharged with plan to complete doxycycline and rifampin therapy however was lost to follow up. A literature review of 10 manuscripts describing 13 cases of B. quintana IE were identified. All the patients were male and the median age was 45. Six of the cases were in Europe and eight were in North America. All cases had left sided valve involvement (10 aortic, 6 mitral, 3 both valves). No cases of right sided IE were identified. Conclusion B. quintana IE should be considered in homeless patients with a clinical presentation concerning for IE. A combination of serology and PCR testing can be useful in diagnosis of this uncommon cause of infective endocarditis. Disclosures Jeffrey Klausner, MD, MPH, Nothing to disclose

scholarly journals Metastatic Crohn's disease of the umbilicus.

BMJ ◽  
1981 ◽  
Vol 283 (6296) ◽  
pp. 887-887 ◽  
Author(s):  
R K Phillips ◽  
G Glazer
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Metastatic Crohn's Disease

scholarly journals Metastatic Crohn’s disease despite infliximab therapy

2017 ◽  
Vol 92 (5 suppl 1) ◽  
pp. 104-106 ◽  
Author(s):  
Sara Campos ◽  
Inês Coutinho ◽  
José Carlos Cardoso ◽  
Francisco Portela
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Infliximab Therapy ◽  
Metastatic Crohn's Disease

Non-infective endocarditis in Crohn’s disease: an anecdotal case of obstructive shock

2021 ◽  
Author(s):  
Valentino Dammassa ◽  
Claudia Raineri ◽  
Marco Aiello ◽  
Francesco Mojoli ◽  
Guido Tavazzi
Keyword(s):  
Crohn’S Disease ◽  
Infective Endocarditis ◽  
Crohn's Disease ◽  
Obstructive Shock

Metastatic Crohn's disease

1976 ◽  
Vol 95 (5) ◽  
pp. 551-554 ◽  
Author(s):  
D.I. McCALLUM ◽  
W.M. GRAY
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Metastatic Crohn's Disease

Metastatic Crohn's disease

2020 ◽  
Vol 154 (12) ◽  
pp. 527
Author(s):  
Cristina Martínez ◽  
Eduardo Corradini ◽  
Roberto Cullen ◽  
Rosemarie Bentjerodt
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Metastatic Crohn's Disease

Metastatic Crohn's disease: Two cases of penile Crohn's and literature review

2010 ◽  
Vol 6 (3) ◽  
pp. 270-273 ◽  
Author(s):  
V.A. Lane ◽  
P. Vajda ◽  
D. King ◽  
J. Stahlschmidt ◽  
I. Sugarman ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Literature Review ◽  
Metastatic Crohn's Disease

scholarly journals Myocarditis in Crohn’s disease: a case report

2020 ◽  
Vol 4 (4) ◽  
pp. 1-6
Author(s):  
Lucy McGrath-Cadell ◽  
Nicole K Bart ◽  
Linda Lin ◽  
Simon Ghaly ◽  
Cameron J Holloway
Keyword(s):  
Crohn’S Disease ◽  
Infective Endocarditis ◽  
Crohn's Disease ◽  
Blood Cultures ◽  
Empirical Treatment ◽  
Diagnostic Process ◽  
Treatment Paradigm ◽  
History Of ◽  
Culture Negative ◽  
Valvular Lesions

Abstract Background Mobile valvular masses are often considered pathognomonic for infective endocarditis. We present a case of a young patient with mobile valvular masses in the context of myocarditis likely secondary to active ileal Crohn’s disease. Cardiac magnetic resonance (CMR) imaging was crucial in diagnosing and monitoring our patient. Case summary A 27-year-old woman presented with pleuritic chest pain, dyspnoea, and a 3-day history of fevers. She also reported a 2-month history of intermittent visual loss in her right eye. She had a history of histologically proven ileal Crohn’s disease, diagnosed 5 months prior. She was haemodynamically unstable on presentation. Abnormalities on a transthoracic echocardiogram necessitated a transoesophageal echocardiogram. After blood cultures were sent, the patient was commenced on empirical treatment for infective endocarditis with gentamicin and flucloxacillin. Eight days after her initial presentation, all blood cultures remained negative and she was changed to empirical treatment for culture negative endocarditis with ceftriaxone and vancomycin, according to local protocol. Despite 8 days of treatment for infective endocarditis she remained febrile. A CMR was organized on Day 9 and this showed myocarditis, which changed the treatment paradigm. She responded swiftly to steroids and anti-coagulation. Discussion In this case, echo-dense valvular lesions are not pathognomonic for infective endocarditis and a careful diagnostic process involving multi-modality imaging, including CMR, occurred to arrive at a diagnosis of myocarditis likely secondary to Crohn’s disease.

Metastatic Crohn's Disease of the Lung

1998 ◽  
Vol 27 (3) ◽  
pp. 338-341 ◽  
Author(s):  
Predrag Minic ◽  
Vojislav N. Perisic ◽  
Aleksandra Minic
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Metastatic Crohn's Disease
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