scholarly journals The Association Between Visceral Adipose Tissue and Stricturing Crohn’s Disease Behavior, Fecal Calprotectin, and Quality of Life

2018 ◽  
Vol 25 (6) ◽  
pp. e61-e61
Author(s):  
Cong Dai ◽  
Min Jiang ◽  
Yu-Hong Huang
Keyword(s):  
Quality Of Life ◽  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Visceral Adipose Tissue ◽  
Fecal Calprotectin ◽  
Disease Behavior ◽  
Visceral Adipose

scholarly journals Visceral Adipose Tissue Is Associated With Stricturing Crohn’s Disease Behavior, Fecal Calprotectin, and Quality of Life

2018 ◽  
Vol 25 (3) ◽  
pp. 592-600 ◽  
Author(s):  
Robert Venning Bryant ◽  
Christopher G Schultz ◽  
Soong Ooi ◽  
Charlotte Goess ◽  
Samuel Paul Costello ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Visceral Adipose Tissue ◽  
Fecal Calprotectin ◽  
Disease Behavior ◽  
Visceral Adipose

scholarly journals Authors’ reply: The Association Between Visceral Adipose Tissue and Stricturing Crohn’s Disease Behavior, Fecal Calprotectin and Quality of Life

2018 ◽  
Vol 25 (6) ◽  
pp. e62-e63
Author(s):  
Robert Venning Bryant ◽  
Christopher G Schultz ◽  
Soong Ooi ◽  
Charlotte Goess ◽  
Samuel Paul Costello ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Visceral Adipose Tissue ◽  
Fecal Calprotectin ◽  
Disease Behavior ◽  
Visceral Adipose

scholarly journals IRGMGene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn’s Disease

2018 ◽  
Vol 24 (10) ◽  
pp. 2247-2257 ◽  
Author(s):  
Tracey G Simon ◽  
Kimberley W J Van Der Sloot ◽  
Samantha B Chin ◽  
Amit D Joshi ◽  
Paul Lochhead ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Visceral Adipose Tissue ◽  
Visceral Adipose ◽  
The Relationship

scholarly journals Effect of Originator Infliximab Treatment on Disease-Related Hospitalizations, Work Productivity and Activity Impairment, and Health Resource Utilization in Patients with Crohn’s Disease in a Real-Life Setting: Results of a Prospective Multicenter Study in Germany

2020 ◽  
pp. 1-13
Author(s):  
Niels Teich ◽  
Michael Bläker ◽  
Frank Holtkamp-Endemann ◽  
Eric Jörgensen ◽  
Andreas Stallmach ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Multicenter Study ◽  
Work Productivity ◽  
Infliximab Treatment ◽  
Prospective Multicenter Study ◽  
Hospitalization Rates ◽  
The Mean

<b><i>Introduction:</i></b> Infliximab (IFX) therapy is efficacious for inducing and maintaining symptomatic remission in patients with Crohn’s disease (CD), but whether this benefit results in reduced hospitalization rates and therefore may improve patients’ quality of life in an economically sensible way is conflicting so far. <b><i>Methods:</i></b> We conducted a noninterventional, multicenter, open-label, prospective study to evaluate the effect of originator IFX treatment on patient-reported outcomes and disease-related hospitalizations in adult CD patients in Germany treated for the first time with IFX according to label. <b><i>Results:</i></b> Two hundred and ninety-four patients were included in the study. We observed a statistically significant reduction in the number of CD-related hospitalizations from the year before baseline (mean 1.00 per patient, SD ± 0.93) to the mean value of the 1st (0.62, SD ± 0.95) and 2nd year (0.32, SD ± 0.75) of the observation period (<i>p</i> &#x3c; 0.0001). After 3 months of IFX therapy, work productivity and activity increased by an average of 12.6 and 17.1%, respectively. Patient’s clinical outcome was markedly improved as the total CD activity index (CDAI) sum score continuously decreased from baseline to month 24 and the mean score of the total inflammatory bowel disease questionnaire (IBDQ) changed substantially from 141 at baseline to 172 after 24 months of IFX treatment. Additionally, the number of work incapacity days declined. Recently, no new safety issues of IFX have been identified. <b><i>Conclusion:</i></b> In this large, prospective, multicenter study on disease-related hospitalization rates, work productivity, capacity for daily activities, and HRQoL in patients with CD, IFX significantly reduces their hospitalization rates and improves work productivity, daily activity, and quality of life over 24 months.

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