Delivery Outcomes of Pregnant Patients With Inflammatory Bowel Diseases Compared With the General Population and With Women With Other Autoimmune Diseases at a Tertiary Care Center

2020 ◽  
Author(s):  
Taylor Geisman ◽  
Ling Chen ◽  
Margaret Rosanna Gray-Swain ◽  
Deborah Hiatt-Jensen ◽  
Alexandra Gutierrez
Keyword(s):  
General Population ◽  
Autoimmune Diseases ◽  
Cesarean Delivery ◽  
Inflammatory Bowel Diseases ◽  
Pregnancy Outcomes ◽  
Cesarean Deliveries ◽  
Delivery Outcomes ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Adverse Pregnancy

Abstract Background Variable data have suggested that pregnant women with inflammatory bowel diseases (IBD) are more likely to have cesarean deliveries and adverse pregnancy outcomes than the general population. The aim of this study was to describe the rates of cesarean delivery and adverse pregnancy outcomes among patients with IBD as compared with patients with other autoimmune diseases and with the general population. Methods Pregnant patients with IBD, those with non-IBD autoimmune diseases, and control patients were identified. Baseline demographics, disease characteristics, medication use, and delivery outcomes were recorded in a retrospective manner. The primary outcome was overall rate of cesarean delivery; secondary outcomes included rates of planned and unplanned cesarean delivery, delivery complications, preterm delivery, and fetal complications. Results Ninety-three women with IBD were age-matched to 376 control patients; 38 women with other autoimmune diseases were also identified. Women with IBD had higher rates of cesarean delivery (47%) when compared with control patients (31%; P < 0.0001) but not when compared with women with other autoimmune diseases. There were high rates of planned cesarean deliveries for IBD-related factors in the IBD cohort. Women with IBD did not have increased rates of adverse delivery or fetal outcomes. Conclusions Women with IBD have higher rates of cesarean delivery than the general population and rates similar to those of women with other autoimmune diseases. Planned cesarean delivery plays an important role in maintaining continuity and sphincter control in select situations, but a diagnosis of IBD does not mandate cesarean delivery.

Fertility and Pregnancy in Inflammatory Bowel Disease

2015 ◽  
Author(s):  
Aoibhlinn M. O’Toole ◽  
Sonia Friedman
Keyword(s):  
Pregnancy Outcomes ◽  
Mode Of Delivery ◽  
Reproductive Function ◽  
Pregnant Patient ◽  
Ileoanal Pouch ◽  
Bowel Diseases ◽  
Individualized Approach ◽  
Inflammatory Bowel ◽  
Adverse Pregnancy ◽  
In Pregnancy

Inflammatory bowel diseases (IBDs) commonly affect women in their reproductive years; 25% of women with IBD become pregnant after the diagnosis. The relation of IBD to reproductive function often manifests in issues concerning fertility, antepartum pregnancy management, mode of delivery, and lactation as these can be influenced by disease activity, medications, perianal disease, and previous ileoanal pouch surgery. As disease location, activity, and complications can vary between patients, an individualized approach with multidisciplinary management is recommended. Pregnancy outcomes, recommended medication, nursing, managing IBD flares during pregnancy, and immune pathways are also discussed. Figures show issues discussed in preconception counseling and pregnancy guidelines. Tables list medication recommendations, Food and Drug Administration categories for the use of medications in pregnancy, adverse pregnancy outcomes PIANO registry, pregnancy and biological recommendations, thiopurine recommendations, safety of biologics in pregnancy, biologic guidelines, and sick pregnant patient recommendations. This review contains 2 highly rendered figures, 8 tables, and 29 references. 

scholarly journals Perinatal risk factors for pediatric onset type 1 diabetes, autoimmune thyroiditis, juvenile idiopathic arthritis, and inflammatory bowel diseases

2021 ◽  
Author(s):  
Laura Räisänen ◽  
Heli Viljakainen ◽  
Catharina Sarkkola ◽  
Kaija-Leena Kolho
Keyword(s):  
Risk Factors ◽  
Type 1 Diabetes ◽  
Juvenile Idiopathic Arthritis ◽  
Autoimmune Diseases ◽  
Autoimmune Thyroiditis ◽  
Inflammatory Bowel Diseases ◽  
Preterm Children ◽  
Bowel Diseases ◽  
Inflammatory Bowel

AbstractType 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD) are common pediatric autoimmune diseases with unknown risk factors. Using nationwide registers, we searched for their perinatal risk factors. Our study followed up 11,407 children (born 2000–2005) for a median of 16.6 years (from birth to 2018). Of them, 2.15% received primary diagnosis and 0.08% also secondary: 0.89% had DM, 0.60% had AIT, 0.48% had JIA, and 0.25% had IBD. The incidences per 100,000 children/year were 106.1 for DM, 46.0 for AIT, 55.0 for JIA, and 23.7 for IBD. There were more preterm births (< 37 weeks) among children with studied autoimmune diseases compared with the rest of the cohort (8.6% vs. 5.3%, p = 0.035). Among those born preterm, children with studied autoimmune diseases received more postnatal antibiotics compared with other preterm children in the cohort (47.6% vs. 27.7%, p = 0.046). Children with IBD were born to older mothers compared with those without studied diagnoses (33.0 vs 30.2, p = 0.004).Conclusion: Preterm birth was a shared risk factor for autoimmune diseases in our study, especially when combined with postnatal antibiotic treatments. High maternal age was associated with IBD. What is Known:• Type 1 diabetes (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD) are common pediatric autoimmune diseases• It is unclear whether these diseases have shared risk factors, since there are no previous simultaneous epidemiological nor follow-up studies on them in one cohort  What is New:• Preterm births were more common in children with DM, AIT, JIA, or IBD compared with other children in the cohort, and preterm children who developed these diseases recieved more postnatal antibiotics compared with other preterm children• High maternal age was associated with IBD

Exploring pharmacogenetic variants for predicting response to anti-TNF therapy in autoimmune diseases: a meta-analysis

2021 ◽  
Author(s):  
Charalabos Antonatos ◽  
Eleana F Stavrou ◽  
Evangelos Evangelou ◽  
Yiannis Vasilopoulos
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Diseases ◽  
Inflammatory Bowel Diseases ◽  
Meta Analysis ◽  
European Descent ◽  
Systematic Overview ◽  
Tnf Α ◽  
Subgroup Analyses ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Aim: The aim of this study is to explore how SNPs may affect the response to anti-TNF-α therapy in the major autoimmune diseases, such as psoriasis, rheumatoid arthritis, inflammatory bowel diseases and Spondyloarthritis. Methodology: We conducted a systematic overview on the field, by assessing all studies that examined the association between polymorphisms and response to anti-TNF-α therapy in participants of European descent. Results: In total, six independent SNPs located in FCGR2A, FCGR3A, TNF-α and TNFRSF1B genes were significantly associated with response to TNF-α blockers, found mainly in disease-subgroup analyses. Conclusion: No common pharmacogenetic variant was identified for all autoimmune diseases under study, suggesting the requirement of more studies in the field in order to capture such predictive variants that will aid treatment selection.

Increased Mortality of Patients With Childhood-Onset Inflammatory Bowel Diseases, Compared With the General Population

2019 ◽  
Vol 156 (3) ◽  
pp. 614-622 ◽  
Author(s):  
Ola Olén ◽  
Johan Askling ◽  
Michael C. Sachs ◽  
Paolo Frumento ◽  
Martin Neovius ◽  
...  
Keyword(s):  
General Population ◽  
Inflammatory Bowel Diseases ◽  
Childhood Onset ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Effects of Anti–Helicobacter pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases

2019 ◽  
Vol 17 (10) ◽  
pp. 1991-1999 ◽  
Author(s):  
Kun-Der Lin ◽  
Guei-Fen Chiu ◽  
Akbar K. Waljee ◽  
Stephanie Y. Owyang ◽  
Mohamad El-Zaatari ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Autoimmune Diseases ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals 816 – Effects of Anti-Helicobacter Pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases

2019 ◽  
Vol 156 (6) ◽  
pp. S-172
Author(s):  
Kun-Der Lin ◽  
Guei-Fen Chiu ◽  
Akbar K. Waljee ◽  
Stephanie Y. Owyang ◽  
Mohamad El-Zaatari ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Autoimmune Diseases ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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