The impact of embryo quality on singleton birthweight in vitrified-thawed single blastocyst transfer cycles

2020 ◽  
Vol 35 (2) ◽  
pp. 308-316 ◽  
Author(s):  
Jie Zhang ◽  
Jiaan Huang ◽  
Hongfang Liu ◽  
Bian Wang ◽  
Xiaoyan Yang ◽  
...  
Keyword(s):  
Embryo Quality ◽  
Conflicts Of Interest ◽  
Linear Regression Analysis ◽  
Tertiary Care ◽  
Poor Quality ◽  
Blastocyst Transfer ◽  
Excellent Quality ◽  
Z Scores ◽  
The Impact ◽  
The Relationship

Abstract STUDY QUESTION Does the quality of a single transferred blastocyst affect singleton birthweight in frozen-embryo transfer (FET) cycles? SUMMARY ANSWER The transfer of a poor-quality blastocyst was associated with lower mean birthweight and gestation-adjusted birthweight (Z-scores) when compared with the transfer of an excellent-quality blastocyst during FET cycles. WHAT IS KNOWN ALREADY Embryo quality is a strong predictor of IVF success rates. However, very few studies have examined the effect of embryo quality on singleton birthweight. STUDY DESIGN, SIZE, DURATION This retrospective study involved singleton live births born to women undergoing frozen-thawed single blastocyst transfers during the period from January 2010 to December 2017 at a tertiary care centre. PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 1207 women who fulfilled the inclusion criteria were included and were grouped into four groups depending on the blastocyst quality: excellent, good, average and poor. The primary outcome measure was singleton birthweight. The Z-score was employed to calculate the birthweight adjusted for gestational age and newborn gender. Multiple linear regression analysis was performed to investigate the relationship between embryo quality and neonatal birthweight after adjustment for some potential confounders. MAIN RESULTS AND THE ROLE OF CHANCE In the primary multivariable model, singletons from the poor-quality blastocyst group weighed 183.5 g less than those from the excellent-quality blastocyst group (95% CI: −295.1 to −71.9 g, P = 0.001) in terms of mean birthweight after accounting for patient characteristics, IVF treatment parameters, the year of treatment and newborn gender. Likewise, poor-quality blastocyst transfer was associated with lower gestation-adjusted Z-scores than the transfer of excellent-quality blastocysts (β = −0.35, 95% CI: −0.59 to −0.12, P = 0.003). LIMITATIONS AND REASONS FOR CAUTION The current study was limited by its retrospective design and the fact that our analysis was restricted to women with singleton births from single blastocyst transfers. Future prospective studies are required to confirm our findings. WIDER IMPLICATIONS OF THE FINDINGS Our findings provide new insight into the relationship between embryo quality and neonatal outcomes by showing that poor-quality blastocyst transfer was associated with a decrease in singleton birthweight. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by the National Key Research and Development Program of China (grant no. 2018YFC1003000), the National Natural Science Foundation of China (grant nos. 81771533, 81571397 and 31770989), and the China Postdoctoral Science Foundation (Grant no. 2018M630456). The authors have no conflicts of interest to declare. TRIAL REGISTRATION NUMBER Not applicable.

Effect of endometrial thickness on birthweight in frozen embryo transfer cycles: an analysis including 6181 singleton newborns

2019 ◽  
Vol 34 (9) ◽  
pp. 1707-1715 ◽  
Author(s):  
Jie Zhang ◽  
Hongfang Liu ◽  
Xiaoyan Mao ◽  
Qiuju Chen ◽  
JiQiang Si ◽  
...  
Keyword(s):  
Linear Regression ◽  
Embryo Transfer ◽  
Gestational Age ◽  
Endometrial Thickness ◽  
Linear Regression Analysis ◽  
Tertiary Care ◽  
Frozen Embryo Transfer ◽  
Z Scores ◽  
The Impact ◽  
The Relationship

Abstract STUDY QUESTION Does endometrial thickness (EMT) have an impact on singleton birthweight in frozen embryo transfer (FET) cycles? SUMMARY ANSWER An EMT <8 mm was associated with a lower mean birthweight and gestational age- and gender-adjusted birthweight (Z-scores) of singletons resulting from FET. WHAT IS KNOWN ALREADY Previous studies have examined the impact of EMT on IVF success rates. Little is known, however, regarding the relationship between EMT and neonatal birthweight. STUDY DESIGN, SIZE, DURATION This retrospective study involved singleton live births born to women undergoing frozen-thawed Day 3 embryo transfer during the period from January 2010 to December 2017 at a tertiary care centre. PARTICIPANTS/MATERIALS, SETTING, METHODS A total of 6181 women who fulfilled the inclusion criteria were included and were grouped into five groups depending on the EMT: <8 mm, 8–9.9 mm, 10–11.9 mm, 12–13.9 mm and ≥14 mm. EMT between 10 and 11.9 mm was taken as a reference group. Singleton birthweight was the primary outcome measure. A multivariable linear regression analysis was performed to detect a relationship between EMT and newborns' birthweight after controlling for a number of potential confounders. MAIN RESULTS AND THE ROLE OF CHANCE A modest but significant decrease in birthweight was observed in the EMT <8 mm group as compared with groups with EMT ≥10 mm, with a mean difference of 89–108 g. Also, singletons from the EMT <8 mm group (0.24 ± 1.04) had a significantly lower birthweight Z-scores than those from the EMT 10–11.9 mm (0.41 ± 1.02; P = 0.032) or EMT 12–13.9 mm (0.46 ± 1.07; P = 0.004) groups. Further, multiple linear regression analyses indicated that parental BMIs, gestational age, newborn gender, pregnancy complications and EMT <8 mm were all independent predictors of neonatal birthweight. LIMITATIONS, REASONS FOR CAUTION The present study was limited by its retrospective design. Future prospective studies are required to confirm our findings. WIDER IMPLICATIONS OF THE FINDINGS Our findings provided new insight into the relationship between EMT and neonatal outcomes by showing that a thin endometrium is associated with a decrease in singleton birthweight. STUDY FUNDING/COMPETING INTEREST(S) National Key Research and Development Program of China (2018YFC1003000); the National Natural Science Foundation of China (81771533, 81571397, 31770989, 81671520); the China Postdoctoral Science Foundation (2018M630456). The authors have no conflicts of interest to declare. TRIAL REGISTRATION NUMBER Not applicable.

scholarly journals Impact of maternal age on birthweight in frozen embryo transfer cycles: an analysis including 12565 singleton newborns

2020 ◽  
Author(s):  
Zhexin Ni ◽  
Shuai Sun ◽  
Wen Cheng ◽  
Jin Yu ◽  
Dongxia Zhai ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Maternal Age ◽  
Reference Group ◽  
Linear Regression Analysis ◽  
Tertiary Care ◽  
Frozen Embryo Transfer ◽  
Tertiary Care Centre ◽  
Significant Difference ◽  
Z Scores ◽  
The Relationship

Abstract Background: Previous studies have investigated the effect of maternal age on assisted reproductive technology (ART) success rates. However, little is known about the relationship between maternal age and neonatal birthweight in frozen embryo transfer (FET) cycles. Does maternal age have an impact on singleton birthweight in FET cycles?Methods: This retrospective study was conducted at a tertiary care centre, involving singleton live births born to women undergoing frozen-thawed embryo transfer during the period from January 2010 to December 2017. A total of 12565 women who fulfilled the inclusion criteria were enrolled and were grouped into four groups according to the maternal age: <30, 30–34, 35-39, and ≥40 years old. Maternal age <30 years old was taken as a reference group. Singleton birthweight was the key outcome measure. A multivariable linear regression analysis was conducted to reveal the relationship between maternal age and neonatal birthweight with controlling for a number of potential confounders.Results: A modest decrease but no significant difference in birthweight and gestational age- and gender-adjusted birthweight (Z-scores) was observed in maternal age over 35 years old as compared with group with <30years old. The highest proportions of LBW (4.1%), HBW (1.2%), PTB (5.9%) and very PTB (0.9%) were found in group over 40 years old, but no significant difference was observed among four groups. Additionally, the group with 35-39 years old had the highest very LBW (0.6%) , while the group with 30-34 years old had the lowest SGA (2.7%). However, multivariate analyses revealed that neonatal outcomes including PTB, LBW and SGA were similar between the different maternal age groups.Conclusion: Grouping with different maternal age was not associated with mean birthweight and Z-scores of singletons resulting from FET.

The Impact of Adopting CSR on the Firm's Overall Performance

2021 ◽  
pp. 239-255
Author(s):  
Abdelmajid Ibenrissoul ◽  
Khawla Bouraqqadi ◽  
Souhaila Kammoun
Keyword(s):  
Developing Countries ◽  
Regression Analysis ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Social Dimensions ◽  
The Social ◽  
Managerial Implications ◽  
Overall Performance ◽  
The Impact ◽  
The Relationship

The purpose of the chapter is to study what effect CSR has on firms' overall performance in a developing country context. While most of the previous empirical researches focused on the relationship between CSR and financial performance, the present study suggests exploring the impact of CSR on overall performance which encompasses economic, environmental, and social dimensions as well as stakeholders. The empirical study aims to analyze and measure the social and environmental involvement of large Moroccan firms operating in the main sectors of activity and located in different geographical areas. Using multiple linear regression analysis, the authors empirically test the impact of CSR on overall performance on a sample of 44 companies. The main findings reveal that CSR is a driver for improving image and reputation, enabling the firm to achieve overall corporate performance. On the basis of the main results, they set out some managerial implications and further directions for CSR research in developing countries.

Institution-Wide Quantification of Iatrogenic Blood Loss Using a Novel Informatics-Driven Methodology

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 1530-1530
Author(s):  
Donna L. Ledingham ◽  
Don Doiron ◽  
Bryan Crocker ◽  
Calvino K. Cheng
Keyword(s):  
Critical Care ◽  
Blood Loss ◽  
Patient Outcomes ◽  
Service Providers ◽  
Conflicts Of Interest ◽  
Tertiary Care ◽  
Term Care ◽  
Data Set ◽  
Critical Care Units ◽  
The Impact

Abstract Abstract 1530 Rationale: Anemia has been shown to have an adverse impact on patient outcomes. In the transfusion literature, various blood conservation and patient blood management systems have been proposed as a way to reduce the burden of anemia. An important component of limiting blood loss is the reduction of iatrogenic blood loss through diagnostic phlebotomy. Studies in the phlebotomy and transfusion literature largely focus on small patient populations on critical care units. Such research provides a great depth of information about those settings, but the impact of diagnostic phlebotomy on the broader inpatient population is unknown. We present a novel method, not previously described in the literature, characterising the extent of iatrogenic blood loss in inpatients at our institution. Methods and results: Following a pilot project, data from September 1 to December 1, 2009 were queried from the institution's laboratory information system. This comprehensive dataset included records of tests conducted during 7503 admissions of patients (n=6733) at twelve individual facilities within Capital District Health Authority (CDHA). There were 70,790 unique laboratory orders, for which a total of 397,770 individual tests were performed. This required a total of 120,398 tubes of blood drawn for a cumulative volume of 648,350 mL from the entire population. The majority of tests were done on a “routine” basis (44,820/ 70,790 orders, 63%); most testing was also done after the first day of admission (59,051/ 70,790 orders, 83%). Patient demographics and testing burden are contrasted by gender in Table 1; males appear to experience a higher testing burden than females, despite similar mean length of stay. There were 618 (9%) of 6733 inpatients having ≥250mL (approximately 1 unit of packed red cells) phlebotomised (Table 1). Phlebotomy volumes are unevenly distributed across the age range, with patients in the two youngest age groups demonstrating lower mean cumulative volumes than older patients (Table 2). When individual admissions are examined, phlebotomy volume per patient is greater in hospitals providing tertiary care, as contrasted to other facilities. At the nursing unit level, the cumulative phlebotomy volume exceeded the population average on patients admitted to critical care units, long term care units and medical wards. This trend was also reflected in the testing performance of service providers, where patients cared for by critical care physicians and internal medicine teams had greater than average phlebotomy volumes. Conclusions: The study demonstrates consistent findings with the critical care literature and identifies a patient population – elderly males – who may be at risk for greater phlebotomy volumes. This study also demonstrates that informatics-based methods can be used to quantify phlebotomy-related blood loss across a broad range of facilities, and identify patient and institution-related variables associated with higher total blood loss. This data set will also provide the ability to model the impact of interventions such as small-volume tubes, direct clinician education initiatives, and could be the basis for a feedback tool in the future. Given the widespread use of laboratory information systems throughout the industrialized world, this approach is readily transferable to other institutions, where it may be used to help reduce iatrogenic blood loss, reduce testing costs and improve patient outcomes. Disclosures: No relevant conflicts of interest to declare.

Time for some home truths – exploring the relationship between GPs and social workers

2014 ◽  
Vol 22 (2) ◽  
pp. 51-61 ◽  
Author(s):  
Catherine Mangan ◽  
Robin Miller ◽  
Jeremy Cooper
Keyword(s):  
Social Workers ◽  
Social Care ◽  
Response Rate ◽  
Poor Quality ◽  
Content Type ◽  
Care Services ◽  
Health And Social Care ◽  
The Impact ◽  
The Relationship

Purpose – The purpose of this paper is to explore the relationship between general practitioners (GPs) and social care professionals by reflecting on a project (the Home Truths project) which sought to improve joint working between general practice and social care though an action-research process. Design/methodology/approach – iMPOWER's Home Truths project involved gathering local data regarding joint working in local areas and using this data as a catalyst for change. The Institute of Local Government Studies and the Health Services Management Centre at the University of Birmingham were asked to act as a critical friend to the project. This involved supporting the design of the data collection, offering advice on the process and to carrying out a short evaluation of the impact of the first wave. The paper reflects on the collected data from the sites and information from the impact evaluation. Findings – The paper highlights the poor quality of the relationship between GPs and social workers. Findings that illustrate this include GPs’ poor knowledge of social care services; a perception that social care services were of poor quality and rating the quality of their relationships with social workers as poor. However GPs felt that knowing more about social care could help prevent their patients going into residential care earlier than necessary and wanted to work more closely with social care to exploit the benefits and opportunities. The interventions that have been put in place to try and improve relationships focus on the day-to-day working lives of the professionals rather than attempting to introduce new initiatives. Research limitations/implications – The response rate from GPs in the areas was low (average response rate was 10 per cent in each area) and it may be that only those GPs who are interested in working with social care responded. The initiatives that have been developed appear to be reasonable responses to the issues identified. However, a lack of discrete outcomes through which to measure improvement will make it difficult to demonstrate the impact of the interventions. Originality/value – This paper underlines that despite many years of policy makers promoting better integration, the relationship between the key gate-keepers within the health and social care systems is still poor. The findings from the Home Truths surveys and action plans has gone some way to address the gap identified in the evidence base about the relationships between GPs and social workers.

scholarly journals The impact of project-based organization on competence management practices

2020 ◽  
Vol 9 (2) ◽  
pp. 177-191
Author(s):  
Mohamed Ali Hedhili ◽  
Sami Boudabbous
Keyword(s):  
Management Practices ◽  
Linear Regression Analysis ◽  
Project Managers ◽  
Career Management ◽  
Central Question ◽  
Competence Management ◽  
Training Compensation ◽  
The Impact ◽  
The Relationship ◽  
And Training

The present article aimed at studying the relationship between project-based organization and competence management practices (recruitment, assessment, training, compensation and career management). The central question of our research is formulated as follows: To what extent does project-based organization influence competence management practices? To answer this question, we adopted a quantitative study. A total of 156 Tunisian project managers participated in our survey. We tested our hypotheses through a linear regression analysis. The results show that the majority of competence management practices, namely recruitment, evaluation and training, are more relevant to project-based organizations and thus the three first hypotheses are confirmed. However, other practices, like remuneration and career management, are insensitive to project activities.

scholarly journals Impact of maternal age on birthweight in frozen embryo transfer cycles: an analysis including 12565 singleton newborns

2020 ◽  
Author(s):  
Zhexin Ni ◽  
Shuai Sun ◽  
Wen Cheng ◽  
Jin Yu ◽  
Dongxia Zhai ◽  
...  
Keyword(s):  
Linear Regression ◽  
Embryo Transfer ◽  
Gestational Age ◽  
Maternal Age ◽  
Linear Regression Analysis ◽  
Frozen Embryo Transfer ◽  
Maternal Body Mass Index ◽  
Significant Difference ◽  
Z Scores ◽  
The Relationship

Abstract Background Previous studies have investigated the effect of maternal age on assisted reproductive technology (ART) success rates. However, little is known about the relationship between maternal age and neonatal birthweight in frozen embryo transfer (FET) cycles. Does maternal age have an impact on singleton birthweight in FET cycles?Methods This retrospective study was conducted at a tertiary care centre, involving singleton live births born to women undergoing frozen-thawed embryo transfer during the period from January 2010 to December 2017. A total of 12565 women who fulfilled the inclusion criteria were enrolled and were grouped into four groups according to the maternal age: <30, 30–34, 35–39, and ≥ 40 years old. Maternal age between 30 and 34 years old was taken as a reference group. Singleton birthweight was the key outcome measure. A multivariable linear regression analysis was conducted to reveal the relationship between maternal age and neonatal birthweight with controlling for a number of potential confounders.Results A modest decrease but no significant difference in birthweight and gestational age- and gender-adjusted birthweight (Z-scores) was observed in maternal age over 35 years old as compared with group with 30–34 years old. Further, multiple linear regression analyses indicated that maternal body mass index (BMI), embryo developmental stage at transfer, parity, number of embryos transferred, FET endometrial preparation, endometrial thickness, gestational age and newborn gender were all independent predictors of neonatal birthweight.Conclusion Grouping with different maternal age was not associated with mean birthweight and Z-scores of singletons resulting from FET.

scholarly journals Impact on Utilization and Shift in Treatment Needs Post-COVID Lockdown of Pediatric Dentistry in a Tertiary Care Hospital

2021 ◽  
Vol 2 ◽  
Author(s):  
Bhojraj Nandlal ◽  
Birti Singh ◽  
Arun Gopi
Keyword(s):  
Linear Regression Analysis ◽  
Tertiary Care ◽  
Pediatric Dentistry ◽  
Care Hospital ◽  
Dental Disease ◽  
Care Seeking ◽  
Treatment Needs ◽  
Dental Services ◽  
Number Of Patients ◽  
The Impact

Background: The COVID-19 pandemic has brought all treatments other than emergencies to a halt. Dental disease, being a multifactorial microbial disease, is capable of progressing to pulpits and its sequelae. The purpose of this study is to predict the impact of utilization of dental services and the progression of treatment needs in children during the lockdown and partial lockdown.Methods: Outpatient department data from the year 2017–2019 from the Department of Pediatric and Preventive Dentistry, JSS Dental College was collected. A table of treatments provided was prepared. Utilization of services as care-seeking rates at 10, 25, and 50% were assumed and modeled corresponding to each stage of the lockdown using linear regression analysis. Dental caries progression was calculated as shifts in treatment needs from permanent restorations to temporary restorations, pulpectomies, or extraction, assuming a 10% progress to each sequela.Results: The p-values for 10, 25, and 50% care-seeking rates were 0.021, &lt;0.001, and &lt;0.001, respectively.Conclusion: The number and severity of cases were predicted to have increased. However, after removal of lockdown, it was noted that the number of patients seeking care was significantly less. The advancement in progression of dental disease further adds to the burden of society and caregivers.

scholarly journals Quality of Life and Stigma among Women with Epilepsy during Their Reproductive Years

2021 ◽  
Vol 11 (1) ◽  
pp. 63-71
Author(s):  
Pallerla Srikanth ◽  
Mysore Narasimha Vranda ◽  
Priya Treesa Thomas ◽  
Kenchaiah Raghvendra
Keyword(s):  
Quality Of Life ◽  
Tertiary Care ◽  
Reproductive Age ◽  
Care Hospital ◽  
Age Group ◽  
Stigma Scale ◽  
The Impact ◽  
The Relationship ◽  
Reproductive Age Group

Background and Purpose: The purpose of this study was to understand the relationship between quality of life and stigma among reproductive age group women with epilepsy.Methods: A cross-sectional descriptive study was conducted to assess the data from the 49 women with epilepsy from a tertiary care hospital in India. Quality of life was evaluated with the quality of life in epilepsy-31 questionnaire and stigma was evaluated with the stigma scale of epilepsy. Data also included socio-demographic and clinical characteristics.Results: The mean age of the participants was 24.67±3.72 years. Quality of life total score (r=-0.485**) and seizure worry domain (r=-0.427**) were significantly negatively correlated with stigma total score at p<0.01 level. Being uneducated, married, unemployed, having children, having generalized tonic-clonic seizures, duration of illness (˃10 years), and consuming levetiracetam, anti-epileptic drug (AED), were the significant contributing factors for low quality of life among women with epilepsy during the reproductive age group. Belonging to lower socio-economic status and taking more than two AEDs were also associated with lower quality of life among women with epilepsy, which are trending towards significance.Conclusions: The study assessed the relationship between the quality of life and the Stigma scale of epilepsy and demonstrated the impact of stigma and quality of life on socio-demographic and clinical variables of women with epilepsy under the reproductive age group. To enhance the quality of life and reduce the stigma levels among women with epilepsy, some of the modifiable parameters can be considered by the multidisciplinary health care professionals from the findings of the current research.

scholarly journals What Motivates Medical Students to Engage in Volunteer Behavior During the COVID-19 Outbreak? A Large Cross-Sectional Survey

2021 ◽  
Vol 11 ◽  
Author(s):  
Yu Shi ◽  
Shu-e Zhang ◽  
Lihua Fan ◽  
Tao Sun
Keyword(s):  
Medical Students ◽  
Health System ◽  
Online Survey ◽  
Linear Regression Analysis ◽  
Full Time ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Prosocial Motivation ◽  
The Impact ◽  
The Relationship

After the COVID-19 outbreak, the health status of the general population has suffered a huge threat, and the health system has also encountered great challenges. As critical members of human capital in the health sector, medical students with specialized knowledge and skills have positively fought against the epidemic by providing volunteer services that boosted the resilience of the health system. Although volunteer behavior (VB) is associated with individual internal motivation, there is sparse evidence on this relationship among medical students, especially regarding potential mechanisms. Therefore, this study had two main objectives: (1) to examine the influence of prosocial motivation (PM) of medical students on their VB; and (2) to verify the chain-mediating role of calling and vocation (CV) as well as social responsibility (SR) in the relationship between PM and VB. Study I: a total of 2454 Chinese full-time medical students were invited to complete an online survey. Data analysis was performed using descriptive statistics, Pearson’s correlation coefficient, and multiple linear regression analysis. The results demonstrated that PM significantly affected VB in medical students (β = 0.098, P &lt; 0.001); CV as well as SR chain-mediated the relationship between PM and VB (β = 0.084, P &lt; 0.001). PM promoted the formation of SR by positively evoking CV of medical students, further resulting in increased VB. Study II: A 28 person qualitative interview was conducted. Qualitative data are added to reduce the limitations of online questionnaires. At the same time, we can also critically study the VB of Chinese medical students during COVID-19. The results showed that there were various reasons for medical students to volunteer in the process of fighting against COVID-19, and the experience of volunteer service and the impact on their future life were different. Lastly, the current findings suggest that fostering volunteerism among medical students requires the joint effort of the government, non-profit organizations, and medical colleges.

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