Risk of juvenile idiopathic arthritis among children conceived after fertility treatment: a nationwide registry-based cohort study

2019 ◽  
Vol 34 (6) ◽  
pp. 1139-1145
Author(s):  
C D Sperling ◽  
S K Kjaer ◽  
M Hargreave ◽  
A Jensen
Keyword(s):  
Cohort Study ◽  
Juvenile Idiopathic Arthritis ◽  
Fertility Treatment ◽  
Nationwide Registry

scholarly journals POS1329 A COHORT STUDY ON THE RISK OF DEVELOPING OBSTRUCTIVE SLEEP APNEA, TEMPOROMANDIBULAR JOINT DISORDERS AND CRANIOFACIAL DEFORMITIES IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 947.1-947
Author(s):  
K. S. K. MA ◽  
L. T. Wang
Keyword(s):  
Obstructive Sleep Apnea ◽  
Cohort Study ◽  
Juvenile Idiopathic Arthritis ◽  
Cox Proportional Hazard Model ◽  
Proportional Hazard ◽  
Proportional Hazard Model ◽  
Cox Proportional Hazard ◽  
Obstructive Sleep ◽  
Subgroup Analyses ◽  
Underlying Mechanisms

Background:Juvenile Idiopathic Arthritis (JIA), an autoimmune disease, has been proposed to be comorbid with obstructive sleep apnea (OSA).Objectives:We aimed at identifying the relationship between JIA and OSA.Methods:We performed a cohort study including JIA and OSA patients from 1999 to 2013. A total of 2791 patients diagnosed with OSA after JIA onset were recruited, which 11,164 eligible individuals without JIA history were selected as matched-controls. A Cox proportional hazard model was developed to estimate the risk of OSA in JIA patients. A cumulative probability model was adopted to assess the time-dependent effect of JIA on OSA development, implying the casual link of the association. To identify whether JIA patients have higher risks for developing temporomandibular joint (TMJ) disorders, craniofacial anomalies and deformities than non-JIA individuals, subgroup analyses was conducted. Finally, Ingenuity Systems Pathway Analysis (IPA) was conducted to identify underlying mechanisms of the above disease correlation among peripheral blood mononuclear cells (PBMCs) from rheumatic factor (RF)-positive and RF-negative JIA patients, and subcutaneous fat tissues from OSA patients, using p-value visualization for RNA-seq analyses.Results:The Cox proportional hazard model showed that JIA patients were more likely to have OSA than non-JIA individuals (adjusted hazard ratio =1.949, 95% CI =1.264–3.005). The incidence of developing OSA was particularly high among patients who developed JIA aged 18-30 years old (aHR= 2.034, 95% CI=1.305-3.169) and males (aHR=1.82, 95% CI=1.121-2.954). The risk of developing OSA increased within 0-36 months (aHR = 2.216, 95% CI = 1.001 – 4.907) and over 60 months (aHR = 2.558, 95% CI = 1.346 – 4.860) of follow-up duration after JIA onset. Subgroup analyses showed that JIA patients were more likely to have TMJ disorders (relative risk = 2.047, 95% CI = 1.446-2.898) and to receive treatment for craniofacial deformities (RR = 1.722, 95% CI = 1.38-2.148) than non-JIA controls. IPA analyses suggested that the underlying mechanisms involved activation of antigen presentation pathway followed by antigen presentation to CD4+ and CD8+ T lymphocytes, as well as B cell development.Conclusion:Our findings identified high risks of developing OSA, TMJ disorders, and craniofacial deformities following JIA onset, which the underlying mechanisms may involve both cellular and humoral immunity.Disclosure of Interests:None declared

Endometrial cancer risk after fertility treatment: a population-based cohort study

2021 ◽  
Author(s):  
Sonia Guleria ◽  
Allan Jensen ◽  
Vanna Albieri ◽  
Bugge Nøhr ◽  
Kirsten Frederiksen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Fertility Treatment ◽  
Endometrial Cancer Risk

A nationwide registry-based cohort study of incidence of tonsillectomy in Denmark, 1991-2012

2017 ◽  
Vol 43 (1) ◽  
pp. 274-284 ◽  
Author(s):  
Marie Louise Juul ◽  
Eva Rye Rasmussen ◽  
Stig Hebbelstrup Rye Rasmussen ◽  
Christian Hjort Sørensen ◽  
Michael Frantz Howitz
Keyword(s):  
Cohort Study ◽  
Nationwide Registry

scholarly journals Herpes Simplex Encephalitis in Denmark: A Nationwide Registry-Based Cohort Study From 2004 to 2014

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Laura Krogh Jørgensen ◽  
Lars Skov Dalgaard ◽  
Lars Østergaard ◽  
Mette Nørgaard ◽  
Trine Mogensen
Keyword(s):  
Cohort Study ◽  
Herpes Simplex ◽  
Herpes Simplex Encephalitis ◽  
Nationwide Registry

scholarly journals Early Self‐Reported Pain in Juvenile Idiopathic Arthritis as Related to Long‐Term Outcomes: Results From the Nordic Juvenile Idiopathic Arthritis Cohort Study

2019 ◽  
Vol 71 (7) ◽  
pp. 961-969 ◽  
Author(s):  
Ellen Dalen Arnstad ◽  
Veronika Rypdal ◽  
Suvi Peltoniemi ◽  
Troels Herlin ◽  
Lillemor Berntson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Juvenile Idiopathic Arthritis ◽  
Long Term Outcomes

scholarly journals AB1276 THE RISK OF DIABETES MELLITUS IN PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS: A COHORT STUDY

2019 ◽  
Author(s):  
Hemin Lee ◽  
Yinzhu Jin ◽  
Jun Liu ◽  
Ezra Cohen ◽  
Sarah Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cohort Study ◽  
Juvenile Idiopathic Arthritis

scholarly journals Microbiome Analytics of the Gut Microbiota in Patients With Juvenile Idiopathic Arthritis: A Longitudinal Observational Cohort Study

2019 ◽  
Vol 71 (6) ◽  
pp. 1000-1010 ◽  
Author(s):  
E. H. Pieter Dijkhuizen ◽  
Federica Del Chierico ◽  
Clara Malattia ◽  
Alessandra Russo ◽  
Denise Pires Marafon ◽  
...  
Keyword(s):  
Cohort Study ◽  
Juvenile Idiopathic Arthritis ◽  
Gut Microbiota ◽  
Observational Cohort Study ◽  
Observational Cohort

Increased short‐ and long‐term mortality following infections in dementia: a nationwide registry‐based cohort study

2020 ◽  
Author(s):  
J. Janbek ◽  
L. Taudorf ◽  
C. S. Musaeus ◽  
N. Frimodt‐Møller ◽  
T. M. Laursen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Nationwide Registry ◽  
Short And Long Term ◽  
Long Term Mortality
Sign in / Sign up

Export Citation Format

Share Document