scholarly journals Effect of cranial irradiation on sperm concentration of adult survivors of childhood acute lymphoblastic leukemia: a report from the St. Jude Lifetime Cohort Study†

2017 ◽  
Vol 32 (6) ◽  
pp. 1192-1201 ◽  
Author(s):  
Daniel M. Green ◽  
Liang Zhu ◽  
Mingjuan Wang ◽  
Wassim Chemaitilly ◽  
DeoKumar Srivastava ◽  
...  
Keyword(s):  
Cohort Study ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Sperm Concentration ◽  
Adult Survivors ◽  
Cranial Irradiation ◽  
Childhood Acute Lymphoblastic Leukemia

scholarly journals Diabetes mellitus among adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort Study

Cancer ◽  
2019 ◽  
Vol 126 (4) ◽  
pp. 870-878 ◽  
Author(s):  
Hannah E. Williams ◽  
Carrie R. Howell ◽  
Wassim Chemaitilly ◽  
Carmen L. Wilson ◽  
Seth E. Karol ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cohort Study ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Adult Survivors ◽  
Childhood Acute Lymphoblastic Leukemia

scholarly journals Elevated Asymmetric Dimethylarginine in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Preliminary Report

2012 ◽  
Vol 33 (2) ◽  
pp. 69-76 ◽  
Author(s):  
Joanna Sulicka ◽  
Andrzej Surdacki ◽  
Magdalena Strach ◽  
Aleksander Kwater ◽  
Barbara Gryglewska ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Asymmetric Dimethylarginine ◽  
Lymphoblastic Leukemia ◽  
Adult Survivors ◽  
Cranial Irradiation ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
High Density Lipoproteins ◽  
Childhood All ◽  
Young Adult Survivors ◽  
Endogenous Nitric Oxide

Background:Adult survivors of childhood malignancy are predisposed to late cardiovascular (CV) complications. Our aim was to estimate plasma levels of the endogenous nitric oxide formation inhibitor asymmetric dimethylarginine (ADMA), in long-term survivors of childhood acute lymphoblastic leukemia (ALL) treated with only chemotherapy.Methods:ADMA and its isomer symmetric dimethylarginine (SDMA) were measured in 25 former ALL patients (aged 18–28 years) who had survived without recurrent disease ≥ 5 years from completing chemotherapy without cranial irradiation, and in 20 healthy controls (aged 20–31 years).Results:Characteristics of the both groups were similar, except for lower high-density lipoproteins-cholesterol (HDL-C) in ALL survivors. Compared to controls, the former ALL patients exhibited significant, albeit small, rises in levels of ADMA (0.63 ± 0.09 [SD] vs. 0.57 ± 0.07 μmol/L;p= 0.016), but not SDMA, with a consequently increased ADMA to SDMA ratio (1.08 ± 0.22 vs. 0.91 ± 0.16;p= 0.004). The effect of former ALL on ADMA was attenuated (intergroupp= 0.10 [ANCOVA]) upon adjustment for HDL-C (ADMA vs. HDL-C regression coefficient: −0.065 ± 0.030 [SEM];p= 0.03).Conclusions:ADMA is elevated in adult childhood ALL survivors, which can reflect late detrimental chemotherapy effects, partially related to minor lipid profile changes. Whether these subtle ADMA elevations might herald future CV morbidity, remains to be elucidated.

Endothelial Function in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia

2008 ◽  
Vol 30 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Donald R. Dengel ◽  
Kirsten K. Ness ◽  
Stephen P. Glasser ◽  
Eric B. Williamson ◽  
K. Scott Baker ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Young Adult ◽  
Endothelial Function ◽  
Lymphoblastic Leukemia ◽  
Adult Survivors ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Young Adult Survivors
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