scholarly journals Nomogram to predict live birth rate after fertility-sparing surgery for borderline ovarian tumours

2016 ◽  
Vol 31 (8) ◽  
pp. 1732-1737 ◽  
Author(s):  
L. Ouldamer ◽  
S. Bendifallah ◽  
I. Naoura ◽  
G. Body ◽  
C. Uzan ◽  
...  
Keyword(s):  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Ovarian Tumours

scholarly journals Fertility-Sparing Treatment and Assisted Reproductive Technology In Patients With Endometrial Carcinoma And Endometrial Hyperplasia: Pregnancy Outcomes After Embryo Transfer

2021 ◽  
Author(s):  
Hilary Friedlander ◽  
Jennifer Blakemore ◽  
David McCulloh ◽  
M. Fino
Keyword(s):  
Endometrial Carcinoma ◽  
Assisted Reproductive Technology ◽  
Embryo Transfer ◽  
Live Birth ◽  
Pregnancy Outcomes ◽  
Endometrial Hyperplasia ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Reproductive Technology ◽  
Fertility Sparing

Abstract Purpose: To evaluate pregnancy outcomes following embryo transfer in patients with endometrial carcinoma (EMCA) or endometrial hyperplasia (EH) who elected for fertility-sparing treatment (FST). Methods: This retrospective cohort study at a large urban university-affiliated fertility center included all patients who underwent embryo transfer after fertility-sparing treatment for EMCA or EH between January 2003 and December 2018. Primary outcomes included embryo transfer results and a live birth rate (defined as number of live births per number of transfers).Results: There were 14 patients, 3 with EMCA and 11 with EH, who met criteria for inclusion with a combined total of 40 embryo transfers. An analysis of observed outcomes by sub-group, compared to the expected outcomes at our center (patients without EMCA/EH matched for age, embryo transfer type and number, and utilization of PGT-A) showed that patients with EMCA/EH after FST had a significantly lower live birth rate than expected (Z = -5.04, df =39, p < 0.01). A sub-group analysis of the 14 euploid embryo transfers resulted in a live birth rate of 21.4% compared to an expected rate of 62.8% (Z = -3.32, df = 13, p < 0.001).Conclusions: Among patients with EMCA/EH who required assisted reproductive technology, live birth rates were lower than expected following embryo transfer when compared to patients without EMCA/EH at our center. Further evaluation of the impact of the diagnosis, treatment and repeated cavity instrumentation for FST is necessary to create an individualized and optimized approach for this unique patient population

scholarly journals Weight loss improve pregnancy and livebirth outcomes in young women with early-stage endometrial cancer and atypical hyperplasia:15 years’ experience

2021 ◽  
Author(s):  
yanfang zhang ◽  
Dan Li ◽  
Qi Yan ◽  
Jinghua Wang ◽  
fei Teng ◽  
...  
Keyword(s):  
Weight Loss ◽  
Endometrial Cancer ◽  
Live Birth ◽  
Birth Rate ◽  
Early Stage ◽  
Live Birth Rate ◽  
Atypical Hyperplasia ◽  
Fertility Sparing ◽  
Weight Loss Group ◽  
Early Stage Endometrial Cancer

Abstract Background: To evaluate the effects of body weight loss on pregnancy and livebirth outcomes in young women with early-stage endometrial cancer (EC) and atypical hyperplasia (AH) with fertility-sparing therapy. Thus, improve the management of this patient group.Method: Patients with AH (n=36) and well-differentiated EC (n=8, FIGO stage IA) who achieved complete regression after conservative treatment were included in this retrospective study. A weight loss group (n=25) and a non-weight loss group (n=19) were divided; while subgroup analysis according to body mass index and stratification analysis according to weight loss proportion were performed to investigate the effect of weight loss on pregnancy and livebirth outcomes. A univariate and multivariate logistic regression analysis were undertaken to analysis the factors associated with pregnancy.Results: The mean body weight and body mass index at pretreatment of progestin and initiation of fertility treatment was 70.63±12.03 and 67.08±8.18 kg, respectively, and 27.06±4.44 and 25.73±3.15 kg/m2, respectively. 25 patients (56.82%) had weight loss; the median weight loss amount is 5.00kg (1.00-34.50), median weigh loss proportion was 6.70% (1.00-36.00) during median time interval of 12months (5.00-97.00). An impressive favorable pregnancy rate (65.91%) and live birth rate (50.00%) were achieved. The pregnancy and livebirth rate were meaningfully higher in the weight loss group than the non-weight loss group (88.00% vs.36.84%,P=0.000; 64.00% vs.31.58%,P=0.033, respectively); weight loss≥5% significantly increased pregnancy and live birth rate in patients with BMI≥25. The risk ratios of weight loss≥5% in multivariate logistic analysis for pregnancy was 0.096(0.010, 0.907).Conclusions: Weight loss could have a positive effect on pregnancy rates and seem to be useful for improving live birth rates in overweight or obese women with early-stage endometrial cancer and atypical hyperplasia during/after fertility-sparing therapy. weight loss≥5% was protective factors of pregnancy in fertility-sparing patients with early-stage endometrial cancer and atypical hyperplasia.

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