scholarly journals Compensated reduction in Leydig cell function is associated with lower semen quality variables: a study of 8182 European young men

2016 ◽  
Vol 31 (5) ◽  
pp. 947-957 ◽  
Author(s):  
N. Jørgensen ◽  
U.N. Joensen ◽  
J. Toppari ◽  
M. Punab ◽  
J. Erenpreiss ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Semen Quality ◽  
Young Men ◽  
Leydig Cell Function

Impaired Testicular Function in Patients With Carcinoma-In-Situ of the Testis

1999 ◽  
Vol 17 (1) ◽  
pp. 173-173 ◽  
Author(s):  
Peter Meidahl Petersen ◽  
Aleksander Giwercman ◽  
Steen W. Hansen ◽  
Jørgen G. Berthelsen ◽  
Gedske Daugaard ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Leydig Cell ◽  
Carcinoma In Situ ◽  
Cell Function ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Testicular Dysfunction ◽  
Leydig Cell Function

PURPOSE: To elucidate the biologic association between germ cell neoplasia and testicular dysfunction, through investigation of Leydig cell function and semen quality in men with carcinoma-in-situ (CIS) of the testis. PATIENTS AND METHODS: We examined two groups of men, unilaterally orchidectomized for testicular cancer. Biopsy of the contralateral testis had showed CIS in a group of 24 patients and no evidence of CIS in the other group of 30 patients. Semen quality and serum levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were compared in these two groups of men after orchidectomy but before further treatment for testicular cancer. RESULTS: Significantly higher LH levels (median, 8.1 IU/L v 4.8 IU/L; P < .001) and generally lower testosterone levels (median, 12.5 nmol/L v 15.5 nmol/L; P = .13) were found in the CIS group. The proportion of patients with Leydig cell dysfunction was higher in the group of patients with CIS (11 of 24) than in the group of patients without (two of 30) (P = .01). Sperm concentration and total sperm count were significantly lower (P < .001) in patients with CIS (median, 0.03 × 106/mL and 0.10 × 106, respectively) than in patients without (median, 9.1 × 106/mL and 32 × 106, respectively), whereas the levels of FSH were significantly higher (P < .001) in the former group of men (median, 19.6 IU/L v 9.0 IU/L). CONCLUSION: Not only spermatogenesis but also Leydig cell function is impaired in testes with CIS. This impairment could be due to common factors in the pathogenesis of germ cell neoplasm and testicular dysfunction. Alternatively, CIS cells may have a negative impact on Leydig cell function.

scholarly journals Decrease in semen quality and Leydig cell function in infertile men: a longitudinal study

2018 ◽  
Vol 33 (11) ◽  
pp. 1963-1974 ◽  
Author(s):  
I A Olesen ◽  
U N Joensen ◽  
J H Petersen ◽  
K Almstrup ◽  
E Rajpert-De Meyts ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Leydig Cell ◽  
Cell Function ◽  
Semen Quality ◽  
Infertile Men ◽  
Leydig Cell Function

Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity

2018 ◽  
Vol 89 (6) ◽  
pp. 442-449
Author(s):  
Saila Laakso ◽  
Heli Viljakainen ◽  
Marita Lipsanen-Nyman ◽  
Ursula Turpeinen ◽  
Kaisa K. Ivaska ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Young Men ◽  
Free Testosterone ◽  
Adolescent And Young Adult ◽  
Control Group ◽  
Adult Males ◽  
Childhood Onset ◽  
Increased Risk ◽  
Leydig Cell Function

Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes, and skeleton at late puberty. Methods: A cohort of adolescent and young adult males with severe childhood-onset obesity (n = 21, mean age 18.5 years) and an age-matched control group were assessed for testicular hormones and X-ray absorptiometry-derived bone mass. Results: Current median body mass indexes for the obese and control subjects were 37.4 and 22.9. Severe early-onset obesity manifested with lower free testosterone (median [interquartile range] 244 [194–332] vs. 403 [293–463] pmol/L, p = 0.002). Lower insulin-like 3 (1.02 [0.82–1.23] vs. 1.22 [1.01–1.46] ng/mL, p = 0.045) and lower ratio of testosterone to luteinizing hormone (2.81 [1.96–3.98] vs. 4.10 [3.03–5.83] nmol/IU, p = 0.008) suggested disrupted Leydig cell function. The degree of current obesity inversely correlated with free testosterone (τ = –0.516, p = 0.003), which in turn correlated positively with bone area at all measurement sites in males with childhood-onset obesity. Conclusions: Severe childhood-onset obesity is associated with impaired Leydig cell function in young men and lower free testosterone may contribute to impaired skeletal characteristics.

Environmental toxins

2013 ◽  
Vol 33 (10) ◽  
pp. 1017-1039 ◽  
Author(s):  
Pallav Sengupta ◽  
Rajdeb Banerjee
Keyword(s):  
Literature Review ◽  
Leydig Cell ◽  
Cell Function ◽  
Pesticide Exposure ◽  
Semen Quality ◽  
Reproductive Physiology ◽  
Environmental Toxins ◽  
Leydig Cell Function

This review comprehensively summarizes the effects of more than 15 mostly used pesticides on male reproductive physiology, as recent experimental and epidemiological research have indicated their alarming impact on overall human health. Mechanisms have described that pesticide exposure damages spermatozoa, alter Sertoli or Leydig cell function, both in vitro and in vivo and thus affects semen quality. But, the literature suggests a need for more intricate research in those pesticides that are defined as mutagens or carcinogens and directly affect the hypothalamic–pituitary–gonadal axis. This literature review also proposes specific solutions to overcome these health effects.

DISORDERS OF LEYDIG CELL FUNCTION IN PRIMARY ADRENAL INSUFFICIENY

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S61
Author(s):  
R. Mies ◽  
D. Heesen ◽  
W. Winkelmann
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Leydig Cell Function

FSH regulates cultured Leydig cell function via Sertoli cell proteins: An in vitro study

1985 ◽  
Vol 132 (2) ◽  
pp. 729-734 ◽  
Author(s):  
M. Benahmed ◽  
C. Grenot ◽  
E. Tabone ◽  
P. Sanchez ◽  
A.M. Morera
Keyword(s):  
Sertoli Cell ◽  
Leydig Cell ◽  
Cell Function ◽  
In Vitro Study ◽  
Vitro Study ◽  
Leydig Cell Function

scholarly journals Leydig Cell Function in Long-term Testosterone-immunized Rats

1983 ◽  
Vol 4 (1) ◽  
pp. 95-103 ◽  
Author(s):  
RICHARD M. SHARPE ◽  
HAMISH M. FRASER
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Leydig Cell Function
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