scholarly journals Trends in ectopic pregnancy rates following assisted reproductive technologies in the UK: a 12-year nationwide analysis including 160 000 pregnancies

2016 ◽  
pp. dev315 ◽  
Author(s):  
Samuel Santos-Ribeiro ◽  
Herman Tournaye ◽  
Nikolaos P. Polyzos
Keyword(s):  
Ectopic Pregnancy ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Pregnancy Rates ◽  
The Uk

scholarly journals From egg to embryo: a peripatetic journey

Reproduction ◽  
2005 ◽  
Vol 130 (6) ◽  
pp. 825-828 ◽  
Author(s):  
Richard M Schultz
Keyword(s):  
Gene Expression ◽  
Assisted Reproductive Technologies ◽  
Egg Quality ◽  
Reproductive Technologies ◽  
Molecular Signature ◽  
High Quality ◽  
Long Term Consequences ◽  
The Uk ◽  
Effect Gene

The recent surge of interest in oocyte development has been spurred in large part by the increasing implementation of assisted reproductive technologies (ART) to treat human infertility. What is becoming apparent is that ‘egg quality’ is a primary factor in the success of ART (Sauer 1998), and yet we know virtually nothing about the molecular signature of a ‘high quality’ oocyte, i.e., an oocyte that is capable of maturing, being fertilized and supporting development to term. We are gaining marked insights, however, into how sperm activate eggs and the changes in gene expression that accompany preimplantation development. Nevertheless, embryo culture is known to effect gene expression (Rinaudo & Schultz 2004), the long-term consequences of which are only recently being unmasked. This review will briefly highlight these topics that were presented during the Biennial Joint Meeting of the UK Fertility Societies at Warwick University in April 2005.

scholarly journals Ectopic Pregnancy and Assisted Reproductive Technologies: A Systematic Review

10.5772/20842 ◽  
2011 ◽  
Author(s):  
Anastasia Velalopoulou ◽  
Dimitrios Peschos ◽  
Mynbaev Ospan ◽  
Eliseeva Marina ◽  
Ioannis Verginadis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ectopic Pregnancy ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies

scholarly journals The Intersection of Reproductive, Work-Life Balance and Early-Education and Care Policies: ‘Solo’ Mothers by Choice in the UK and Spain

2021 ◽  
Vol 10 (12) ◽  
pp. 458
Author(s):  
Ana Bravo-Moreno
Keyword(s):  
Assisted Reproductive Technologies ◽  
Early Education ◽  
Reproductive Technologies ◽  
Work Life ◽  
Work Life Balance ◽  
Life Balance ◽  
Childhood Care ◽  
Education And Care ◽  
The Uk ◽  
The Impact

This article focuses on women who have opted to be mothers on their own by choice in the UK and Spain, and how their access to assisted reproductive technologies in the National Health Service was affected because they were 35 years old or older, forcing them to go to private clinics for their treatment. Having given birth to their children, the participants face a second obstacle: the lack of policies that support work-life balance. A third obstacle also arises, in the form of a lack of childcare and early-education provision, particularly in the UK. The last two obstacles affect the whole population, but they are intensified in the case of solo-mother-families where the mother is responsible for simultaneously being the caregiver and the sole economic provider. Solo motherhood by choice highlights the impact of the absence of these policies, and the inequalities that result from current contemporary conceptualizations of family, woman and early-childhood-care and education. This article draws on ethnographic research that took place in the UK and Spain where I conducted 60 in-depth interviews and participant observations. The aim is to provide an analysis capable of capturing and confronting how inequalities affect women-mothers-workers and their children.

EndoART: A proposed randomized controlled trial on endometriomas in assisted reproductive technologies, comparing the effect of no intervention, surgery, and prolonged GnRH downregulation on pregnancy rates

2018 ◽  
Vol 10 (3) ◽  
pp. 158-173 ◽  
Author(s):  
Carla Tomassetti ◽  
David Adamson ◽  
Aydin Arici ◽  
Michel Canis ◽  
Peter Hompes ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Fetal Heart ◽  
Assisted Reproductive Technologies ◽  
Controlled Trial ◽  
Reproductive Technologies ◽  
Heart Beat ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Randomized Controlled ◽  
Ovarian Surgery

Background: Clinical management of endometriomas, prior to starting treatment with assisted reproductive technologies (ART), has since long been a matter of debate. Whereas cystectomy has been advocated in the past, recently more evidence has emerged on the potential negative effect of surgery on ovarian reserve. Parallel to this, prolonged downregulation with GnRH-a (gonadotropin-releasing hormone agonists) has been described to improve ART pregnancy rates in women with endometriosis. However, none of these strategies have been assessed in a large randomized controlled trial. The aim of the EndoART study is to assess whether ovarian surgery or prolonged GnRH-a downregulation result in higher pregnancy rates after ART compared to no intervention in women with endometrioma(s). Methods/design: A parallel randomized multi-center trial has been designed to compare ART pregnancy rates in three different treatment groups: no intervention, ovarian surgery, and prolonged hormonal suppression by GnRH-a prior to ART. The primary outcome measure studied is the clinical pregnancy rate with fetal heart-beat within 6 months after initiation of a fresh ART cycle. Secondary outcome measures studied include live birth rate after one initiated fresh ART cycle, cumulative clinical pregnancy rate with fetal heart-beat and live birth rates (after one fully completed ART cycle: initiated fresh + eventual associated frozen embryo transfer cycles), ART–specific data (e.g. number of oocytes, number of good quality embryos), complications, pelvic pain, and quality of life. Conclusion: This trial may answer the most frequently asked questions by both women with endometriosis and physicians: how do you treat endometrioma in women prior to treatment with ART?

Office-Based Diagnostic Hysteroscopy after Recurrent Failures of Assisted Reproductive Technologies: Results and Effects on the Later Pregnancy Rates

2013 ◽  
Vol 20 (6) ◽  
pp. S118-S119
Author(s):  
E. Moratalla Bartolome ◽  
N. Montero Pastor ◽  
I. López Carrasco ◽  
V. Rodríguez Tabares ◽  
E. Sanz Espinosa ◽  
...  
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Pregnancy Rates ◽  
Diagnostic Hysteroscopy

P–354 Analysis of pregnancy and miscarriage rates in anti-centromere antibodies (ACA)-positive patients treated with ART

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Y Kida ◽  
M Tokoro ◽  
H Kitasaka ◽  
T Yoshimura ◽  
N Fukunaga ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Antinuclear Antibody ◽  
Assisted Reproductive Technologies ◽  
Formation Rate ◽  
Reproductive Technologies ◽  
Pregnancy Rates ◽  
Human Embryos ◽  
Antibody Testing ◽  
Miscarriage Rate ◽  
Significant Difference

Abstract Study question Do ACA have an effect on pregnancy and miscarriage rates of human embryos? Summary answer The present results suggest that in ACA-positive cases, the pregnancy rate per transfer was significantly lower, although the miscarriage rate was not affected. What is known already We have previously shown that patients with high levels of anti-centromere antibody (ACA), (one of the anti-nuclear antibodies (ANA)), frequently have dispersal of the female chromosomes in the cytoplasm. Additionally, we reported that the clinical outcome was characterized by a low oocyte maturation rate following ovum pick up and high multiple pronuclear formation rate after fertilization. However, the post-implantation course of embryos with ACA-positive cases has not yet been reported. Therefore, in this study, we analyzed the pregnancy and miscarriage rates in ACA-positive patients treated with Assisted Reproductive Technologies (ART). Study design, size, duration 6581 patients who underwent embryo transfer after antinuclear antibody testing between January 2014 and February 2020 were included in the analysis. Participants/materials, setting, methods The subjects were classified into three groups: ANA-negative (without ACA or any other ANA), ACA-positive (with only ACA) and ANA-positive (with ANA but not ACA). The cycle in which the gestational sac was confirmed was considered a positive pregnancy. The pregnancy and miscarriage rates were compared among the groups using “Ryan Test” for statistical analysis. Main results and the role of chance Of the 6581 eligible cases, the incidence of antinuclear antibody were 71.3% (4695/6581; ANA-negative), 0.9% (61/6581; ACA-positive) and 27.7% (1825/6581; ANA-positive). The pregnancy rates based on the total number of embryo transfer cycles for each were ANA-negative: 31.5% (5283/16792), ACA-positive: 17.6% (41/233), and ANA-positive: 32.4% (1891/5833). The pregnancy rates were significantly lower in the ACA-positive group than in the other groups. The miscarriage rate was 29.4% (1553/5283) in ANA-negative, 31.7% (13/41) in ACA-positive, and 28.0% (529/1891) in ANA-positive, with no significant difference between the three groups. Limitations, reasons for caution Retrospective analysis Wider implications of the findings: ACA-positive patients may benefit from a treatment strategy to increase the absolute number of oocytes by obtained in order to increase the chances of normal fertilization and attainment of implantation. Trial registration number none

scholarly journals 34 Reproductive management of beef females in tropical and sub-tropical environments

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 37-37
Author(s):  
Nicola Oosthuizen ◽  
Pedro Levy Piza Fontes ◽  
G Cliff Lamb
Keyword(s):  
Assisted Reproductive Technologies ◽  
Bos Taurus ◽  
Management Strategies ◽  
Bos Indicus ◽  
The United States ◽  
Reproductive Technologies ◽  
Pregnancy Rates ◽  
Embryo Production ◽  
Reproductive Management

Abstract Bos indicus and Bos taurus cattle diverged from an evolutionary standpoint more than 110,000 years ago. Since then, Bos indicus cattle have undergone genetic adaptations beyond the commonly discussed increased thermo-tolerance and parasite resistance. Several physiological differences exist between Bos indicus and Bos taurus cattle, and it is important to consider these differences when establishing reproductive management strategies. It has been well described that Bos indicus cattle have a delayed onset of puberty and longer periods of postpartum anestrus, yet through the utilization of estrus synchronization protocols these challenges can be attenuated. However, when Bos indicus females are exposed to these protocols, they are known to have smaller dominant follicles, lower expression of estrus, and decreased pregnancy rates to artificial insemination (AI) when compared to Bos taurus females. These factors can be overcome through the utilization of estradiol and progesterone based synchronization protocols, which improve follicular dynamics and yield acceptable pregnancy rates to assisted reproductive technologies in cattle adapted to tropical or subtropical conditions. However, the use of estrogens for synchronization purposes is not permitted in the United States, and cattle producers need to rely on GnRH-based protocols. Another key difference between subspecies, is that Bos indicus females have greater antral follicle counts than Bos taurus females, which proves beneficial for in vitro embryo production. Therefore, an opportunity exists to explore the greater productivity of donors in embryo production in order to improve genetics in herds that utilize these breeds.

scholarly journals All the right moves: why in utero transfer is both important for the baby and difficult to achieve and new strategies for change

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 979
Author(s):  
Helena Watson ◽  
James McLaren ◽  
Naomi Carlisle ◽  
Nandiran Ratnavel ◽  
Tim Watts ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Transfer Process ◽  
Assisted Reproductive Technologies ◽  
Clinical Care ◽  
Multiple Pregnancy ◽  
Reproductive Technologies ◽  
In Utero ◽  
The Uk ◽  
The Right ◽  
The Impact

The best way to ensure that preterm infants benefit from relevant neonatal expertise as soon as they are born is to transfer the mother and baby to an appropriately specialised neonatal facility before birth (“in utero”). This review explores the evidence surrounding the importance of being born in the right unit, the advantages of in utero transfers compared to ex utero transfers, and how to accurately assess which women are at most risk of delivering early and the challenges of in utero transfers. Accurate identification of the women most at risk of preterm birth is key to prioritising who to transfer antenatally, but the administrative burden and pathway variation of in utero transfer in the UK are likely to compromise optimal clinical care. Women reported the impact that in utero transfers have on them, including the emotional and financial burdens of being transferred and the anxiety surrounding domestic and logistical concerns related to being away from home. The final section of the review explores new approaches to reforming the in utero transfer process, including learning from outside the UK and changing policy and guidelines. Examples of collaborative regional guidance include the recent Pan-London guidance on in utero transfers. Reforming the transfer process can also be aided through technology, such as utilising the CotFinder app. In utero transfer is an unavoidable aspect of maternity and neonatal care, and the burden will increase if preterm birth rates continue to rise in association with increased rates of multiple pregnancy, advancing maternal age, assisted reproductive technologies, and obstetric interventions. As funding and capacity pressures on health services increase because of the COVID-19 pandemic, better prioritisation and sustained multi-disciplinary commitment are essential to maximise better outcomes for babies born too soon.

scholarly journals Successful use of Single dose of Methotrexate for the treatment of Unruptured Ectopic Pregnancy at Tribhuvan University Teaching Hospital, Kathmandu, Nepal

2013 ◽  
Vol 7 (1) ◽  
pp. 45-49
Author(s):  
Suniti Rawal
Keyword(s):  
Single Dose ◽  
Ectopic Pregnancy ◽  
Assisted Reproductive Technologies ◽  
Cost Effective ◽  
Reproductive Technologies ◽  
University Teaching ◽  
Transvaginal Sonography ◽  
Emergency Laparotomy ◽  
Cost Effective Alternative ◽  
Ectopic Pregnancies

Ectopic pregnancy continues to be one of the most common gynecologic emergencies. The incidence of ectopic pregnancies which are diagnosed much earlier with the help of advanced tools is in the increasing trend, probably due to extensive use of assisted reproductive technologies and increased pelvic infections. A total of 36 ectopic pregnancies were managed from April 2007- March 2008 among which 33 were ruptured ectopics with haemoperitoneum, treated surgically by emergency laparotomy and salpingectomy. Three unruptured cases were treated with single dose of intramuscular methotrexate followed by serum ß hCG measurement. Transvaginal sonography reassured that medical management of unruptured ectopic pregnancies with systemic single dose of methotrexate was successful with few side effects and a cost effective alternative to traditional surgical management for unruptured ectopic pregnancies. Nepal Journal of Obstetrics and Gynaecology / Vol 7 / No. 1 / Issue 13 / Jan- June, 2012 / 45-49 DOI: http://dx.doi.org/10.3126/njog.v7i1.8836

scholarly journals Effects of Vaginal Misoprostol after Intrauterine Insemination IUI

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Zahraa H. Mohan ◽  
◽  
Nadia M. Al-Hilli ◽  
Mohammad Oda Selman ◽  
◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Assisted Reproductive Technologies ◽  
Positive Impact ◽  
Intrauterine Insemination ◽  
Reproductive Technologies ◽  
Pregnancy Rates ◽  
Control Group ◽  
Infertile Couples ◽  
Vaginal Misoprostol

Intrauterine insemination has an important role in the treatment of infertile couples. Usage of vaginal misoprostol therapy at the time of intrauterine insemination has been investigated, and its tolerability and effects on clinical pregnancy rates still questionable. To assess the effectiveness of vaginal misoprostol on some demographic characteristics and hormones level with a success rate of Intrauterine Insemination. the period of collection of patients extended from Sep. 2018 until May 2019. Eighty- one infertile couples who attended Al Nahrain University, High Institute for Diagnostic Infertility and Assisted Reproductive Technologies, and private fertility clinics were enrolled through this study. Divided into two groups, the next group received 100 μg vaginal misoprostol immediately after completion of the IUI procedure, while the control group was subjected to ordinary IUI procedure without adjunctive therapy. The mean of demographic data of body mass index, age, and duration of infertility was statistically insignificant in control, Misoprostol post- intrauterine insemination. The percentage of pregnancy rate in the control group 5.0% and it 19.5% in the Misoprostol post-intrauterine insemination group. Moreover, there are significant differences in pregnancy rates among all study groups. According to this study, there is no significant result of pregnancy occurrences correlated with, female age, male age, and body mass index, duration of infertility or type of infertility, hormone levels. Misoprostol use after intrauterine insemination has a positive impact on pregnancy outcome in the control group 5.0% and it 19.5% in Misoprostol post- intrauterine insemination group. Smaller doses (100 μg) of misoprostol can decrease side effects without affecting the outcome.

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