scholarly journals First trimester phthalate exposure and anogenital distance in newborns

2015 ◽  
Vol 30 (4) ◽  
pp. 963-972 ◽  
Author(s):  
S. H. Swan ◽  
S. Sathyanarayana ◽  
E. S. Barrett ◽  
S. Janssen ◽  
F. Liu ◽  
...  
Keyword(s):  
First Trimester ◽  
Anogenital Distance ◽  
Phthalate Exposure

scholarly journals Decrease in Anogenital Distance among Male Infants with Prenatal Phthalate Exposure

2005 ◽  
Vol 113 (8) ◽  
pp. 1056-1061 ◽  
Author(s):  
Shanna H. Swan ◽  
Katharina M. Main ◽  
Fan Liu ◽  
Sara L. Stewart ◽  
Robin L. Kruse ◽  
...  
Keyword(s):  
Anogenital Distance ◽  
Phthalate Exposure

Environmental Phthalate Exposure in Relation to Reproductive Outcomes and Other Health Endpoints in Humans

2020 ◽  
pp. 314-339
Author(s):  
Sameena ◽  
Riyes Un Aziz ◽  
Aubid Bashir
Keyword(s):  
Reproductive Behavior ◽  
Fetal Development ◽  
High Volume ◽  
Development Stage ◽  
Consumer Products ◽  
Abnormal Development ◽  
Anogenital Distance ◽  
Phthalate Exposure ◽  
Contaminated Food ◽  
Harmful Effects

Phthalates are the class of chemicals that exhibit numerous adverse effects to health. These non-persistent chemicals are produced in high volume annually and are used in a wide array of industrial consumer products. The overall exposure of phthalates to humans is via ingestion of contaminated food from wrapped materials or dermally via consumer care products. Pthalates are anti-androgenic compounds, so for this reason, they obtrude with the expression of testosterone by manipulating gene expression of proteins and enzymes involved in production of testosterone. The primarily exposure of Pthalates during fetal development stage results in number of harmful effects in male offspring in humans, like abnormalities of the sperm-producing organs, abnormal development of penile, hypospadias, reduced anogenital distance, as well as a risk for prostate cancer and cryptorchidism. The purpose of this chapter was to review the environmental impact of phthalate exposure in relation to reproductive behavior and other health problems in humans.

scholarly journals Prenatal exposure to phthalates is associated with decreased anogenital distance and penile size in male newborns

2013 ◽  
Vol 4 (4) ◽  
pp. 300-306 ◽  
Author(s):  
L. P. Bustamante-Montes ◽  
M. A. Hernández-Valero ◽  
D. Flores-Pimentel ◽  
M. García-Fábila ◽  
A. Amaya-Chávez ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Animal Studies ◽  
Reproductive Tract ◽  
Health Concern ◽  
Public Health Concern ◽  
Anogenital Distance ◽  
Male Reproductive Tract ◽  
Reproductive Effects ◽  
Phthalate Exposure ◽  
Ethylhexyl Phthalate

Reproductive effects from phthalate exposure have been documented mostly in animal studies. This study explored the association between prenatal exposure to phthalate metabolites, anogenital distance and penile measurements in male newborns in Toluca, State of Mexico. A total of 174 pregnant women provided urine samples for phthalate analysis during their last prenatal visit, and the 73 who gave birth to male infants were included in the study. The 73 male newborns were weighed and measured using standardized methods after delivery. After adjusting for creatinine and supine length at birth, significant inverse associations were observed between an index of prenatal exposure to total phthalate exposure and the distance from the anus to anterior base of the penis (β = −0.191 mm per 1 μg/l, P = 0.037), penile width (β = −0.0414, P = 0.050) and stretched length (β = −0.2137, P = 0.034); prenatal exposure to mono-2-ethylhexyl phthalate exposure was associated with a reduction in the stretched length of the penis (β = −0.2604, P = 0.050). Human exposure to phthalates is a public health concern, and the system most vulnerable to its potential effects seems to be the immature male reproductive tract.

An appropriate way to predict fetal gender at first trimester: anogenital distance

2018 ◽  
Vol 32 (12) ◽  
pp. 2012-2016 ◽  
Author(s):  
Mehmet Sipahi ◽  
Vehbi Yavuz Tokgöz ◽  
Şebnem Alanya Tosun
Keyword(s):  
First Trimester ◽  
Anogenital Distance ◽  
Fetal Gender

First trimester phthalate exposure and male newborn genital anomalies

2016 ◽  
Vol 151 ◽  
pp. 777-782 ◽  
Author(s):  
Sheela Sathyanarayana ◽  
Richard Grady ◽  
Emily S. Barrett ◽  
Bruce Redmon ◽  
Ruby H.N. Nguyen ◽  
...  
Keyword(s):  
First Trimester ◽  
Phthalate Exposure

scholarly journals Predictive value and reference ranges of anogenital distance for determining fetal gender in the first trimester

2021 ◽  
Vol 42 (10) ◽  
pp. 1057-1064
Author(s):  
Abdulrahman M. Alfuraih ◽  
Samiah A. Alotaiby ◽  
Mohammed J. Alsaadi ◽  
Hanifa A. Bukhari ◽  
Ali M. Aldhebaib ◽  
...  
Keyword(s):  
Predictive Value ◽  
First Trimester ◽  
Reference Ranges ◽  
Anogenital Distance ◽  
Fetal Gender

Environmental Phthalate Exposure in Relation to Reproductive Outcomes and Other Health Endpoints in Humans

2020 ◽  
pp. 296-328
Author(s):  
Sameena ◽  
Riyes Un Aziz ◽  
Aubid Bashir
Keyword(s):  
Reproductive Behavior ◽  
Fetal Development ◽  
High Volume ◽  
Development Stage ◽  
Consumer Products ◽  
Abnormal Development ◽  
Anogenital Distance ◽  
Phthalate Exposure ◽  
Contaminated Food ◽  
Harmful Effects

Phthalates are the class of chemicals that exhibit numerous adverse effects to health. These non-persistent chemicals are produced in high volume annually and are used in a wide array of industrial consumer products. The overall exposure of phthalates to humans is via ingestion of contaminated food from wrapped materials or dermally via consumer care products. Pthalates are anti-androgenic compounds, so for this reason, they obtrude with the expression of testosterone by manipulating gene expression of proteins and enzymes involved in production of testosterone. The primarily exposure of Pthalates during fetal development stage results in number of harmful effects in male offspring in humans, like abnormalities of the sperm-producing organs, abnormal development of penile, hypospadias, reduced anogenital distance, as well as a risk for prostate cancer and cryptorchidism. The purpose of this chapter was to review the environmental impact of phthalate exposure in relation to reproductive behavior and other health problems in humans.

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