scholarly journals Fertility sparing treatment of recurrent stage I serous borderline ovarian tumours

2013 ◽  
Vol 28 (12) ◽  
pp. 3222-3226 ◽  
Author(s):  
C. Uzan ◽  
E. Muller ◽  
A. Kane ◽  
S. Gouy ◽  
S. Bendifallah ◽  
...  
Keyword(s):  
Stage I ◽  
Fertility Sparing ◽  
Ovarian Tumours

scholarly journals Non-Epithelial Ovarian Cancer, an Experience From Qatar

2020 ◽  
Author(s):  
Ammar Madani ◽  
Nabil Omar ◽  
Hafedh Ghazouani ◽  
Cicy Jacob ◽  
Aladdin Kanbour ◽  
...  
Keyword(s):  
Early Stage ◽  
Good Prognosis ◽  
Stage I ◽  
P Value ◽  
Ovarian Cancers ◽  
Fertility Sparing ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours ◽  
Yolk Sac Tumour

Abstract Background: Nonepithelial Ovarian cancers constitute about 10 % of all ovarian cancers. They are divided into Sex-cord stromal tumours (SCST) and Germ cell tumours (GCT). The Aim is to report the experience at National Centre for Cancer Care and Research (NCCCR) in Qatar. Method: This is a retrospective study reviewing records of all patients over 7 years who presented with a histopathologically diagnosed ovarian SCST and GCT at NCCCR between January 2010 and December 2016. Results: 25 women with Non-Epithelial Ovarian Tumours were identified. 13 women were diagnosed with Ovarian SCST. Median age at presentation was 43 years (Range 16-58). 12 patients had stage I and one patient had Stage III. Four patients had recurrence. The 5 years Overall Survival (OS) was 100% and the 5 years Event Free Survival (EFS) was 69% with P value of 0.02. GCT was diagnosed in 12 women. The median age at presentation was 24 years. (Range 16 – 44). Seven patients (59 %) had teratoma, four patients (33 %) had Dysgerminoma and one patient had Yolk sac tumour (8 %). There was one recurrence. 5 years OS was 100 % and 5 years EFS was 83 % with P value of 0.14. Conclusions: Non-Epithelial ovarian tumours are diagnosed relatively at an early stage and have very good prognosis even if they recur. Survival in our study was excellent with all patients alive and disease free at last follow up. For ovarian SCST, we recommend Complete Surgery (TAH + BSO) particularly if high grade, Stage IC and above or completed childbearing to minimize recurrence. Fertility sparing surgery is appropriate for all patients with Stage I Ovarian GCT and most of the patients with Stage II disease who desire fertility preservation.

All-Cause Mortality After Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer

2017 ◽  
Vol 72 (12) ◽  
pp. 713-715
Author(s):  
Alexander Melamed ◽  
Anthony E. Rizzo ◽  
Roni Nitecki ◽  
Allison A. Gockley ◽  
Amy J. Bregar ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Stage I ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
All Cause Mortality

scholarly journals Ultra-conservative fertility-sparing strategy for bilateral borderline ovarian tumours: an 11-year follow-up

2010 ◽  
Vol 25 (8) ◽  
pp. 1966-1972 ◽  
Author(s):  
S. Palomba ◽  
A. Falbo ◽  
S. Del Negro ◽  
M. Rocca ◽  
T. Russo ◽  
...  
Keyword(s):  
Fertility Sparing ◽  
Ovarian Tumours

Outcomes of Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer: A Proposal for Patient Selection

2010 ◽  
Vol 28 (10) ◽  
pp. 1727-1732 ◽  
Author(s):  
Toyomi Satoh ◽  
Masayuki Hatae ◽  
Yoh Watanabe ◽  
Nobuo Yaegashi ◽  
Osamu Ishiko ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Clear Cell ◽  
Stage I ◽  
Healthy Children ◽  
Favorable Histology ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Stage Ia ◽  
Grade 3

Purpose The objective of this study was to assess clinical outcomes and fertility in patients treated conservatively for unilateral stage I invasive epithelial ovarian cancer (EOC). Patients and Methods A multi-institutional retrospective investigation was undertaken to identify patients with unilateral stage I EOC treated with fertility-sparing surgery. Favorable histology was defined as grade 1 or grade 2 adenocarcinoma, excluding clear cell histology. Results A total of 211 patients (stage IA, n = 126; stage IC, n = 85) were identified from 30 institutions. Median duration of follow-up was 78 months. Five-year overall survival and recurrence-free survival were 100% and 97.8% for stage IA and favorable histology (n = 108), 100% and 100% for stage IA and clear cell histology (n = 15), 100% and 33.3% for stage IA and grade 3 (n = 3), 96.9% and 92.1% for stage IC and favorable histology (n = 67), 93.3% and 66.0% for stage IC and clear cell histology (n = 15), and 66.7% and 66.7% for stage IC and grade 3 (n = 3). Forty-five (53.6%) of 84 patients who were nulliparous at fertility-sparing surgery and married at the time of investigation gave birth to 56 healthy children. Conclusion Our data confirm that fertility-sparing surgery is a safe treatment for stage IA patients with favorable histology and suggest that stage IA patients with clear cell histology and stage IC patients with favorable histology can be candidates for fertility-sparing surgery followed by adjuvant chemotherapy.

scholarly journals Comparison of two fertility-sparing approaches for bilateral borderline ovarian tumours: a randomized controlled study

2006 ◽  
Vol 22 (2) ◽  
pp. 578-585 ◽  
Author(s):  
S. Palomba ◽  
E. Zupi ◽  
T. Russo ◽  
A. Falbo ◽  
S. Del Negro ◽  
...  
Keyword(s):  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Fertility Sparing ◽  
Ovarian Tumours

scholarly journals Disparities in fertility-sparing surgery in adolescent and young women with stage I ovarian dysgerminoma

2018 ◽  
Vol 224 ◽  
pp. 38-43 ◽  
Author(s):  
Laura L. Stafman ◽  
Ilan I. Maizlin ◽  
Matthew Dellinger ◽  
Kenneth W. Gow ◽  
Melanie Goldfarb ◽  
...  
Keyword(s):  
Young Women ◽  
Stage I ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Ovarian Dysgerminoma

scholarly journals Staging Procedures Fail to Benefit Women with Borderline Ovarian Tumours Who Want to Preserve Fertility: A Retrospective Analysis of 448 cases

2020 ◽  
Author(s):  
Na Li ◽  
Jinhai Gou ◽  
Lin Li ◽  
Xiu Ming ◽  
Tingwenyi Hu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Retrospective Analysis ◽  
Univariate Analysis ◽  
Stage I ◽  
Stage Ii ◽  
Advanced Stage ◽  
Cox Regression Analysis ◽  
Fertility Sparing ◽  
Staging Surgery ◽  
Stage Stage

Abstract Background This study aimed to evaluate the effect of clinicopathologic and surgical factors on the prognosis and fertility outcomes of patients with borderline ovarian tumour (BOT). Methods We performed a retrospective analysis of BOT patients who underwent surgical procedures in West China Second University Hospital from January 2008 to January 2015. The disease-free survival (DFS) outcomes and potential prognostic factors were evaluated using the Kaplan-Meier method and Cox regression analysis, respectively. Furthermore, fertility outcomes were analysed using Pearson Χ 2 and Fisher’s correlation tests. Results A total of 448 patients were included, with a median age of 37.1 years and a median follow-up time of 113 months; 52 (11.6%) recurrences were observed, with a mean recurrence interval of 80.2 months and four (0.9%) deaths; 118 (26.3%) patients underwent staging surgery and the remaining 330 (73.7%) underwent unstaged surgery. In total, 233 patients undergoing fertility-sparing surgery (FSS) attempted to conceive, and 92 (39.48%) of them achieved pregnancy. No significant differences in fertility outcomes were found between the staging and unstaged surgery groups ( P = 0.691). In univariate analysis, staging surgery was associated with DFS (hazard ratio [HR] = 2.191; P = 0.005), but it was not an independent prognostic factor ( P = 0.600) for DFS on multivariate analysis. Multivariate Cox analysis revealed that advanced FIGO stage (≥stage II), positive ascites\pelvic washings, and laparotomy approach were independent prognostic factors for DFS in patients with BOT, whereas advanced stage (≥stage II), laparotomy approach, cystectomy-related procedures, invasive implants, and bilateral tumours were independent prognostic factors for DFS in patients undergoing FSS. In addition, laparoscopy resulted in better prognosis than laparotomy in patients with early-stage (stage I) tumours and a desire for fertility preservation. Conclusion Patients with BOT fail to benefit from surgical staging in terms of prognosis and fertility outcomes. Laparoscopy is recommended for patients with stage I disease who desire to preserve their fertility. Physicians should pay more attention to the risk of recurrence in patients who want to preserve fertility with advanced stage (≥stage II) disease, invasive implants, and bilateral tumours, and choose FSS carefully.

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