scholarly journals A feasibility trial of screening women with idiopathic recurrent miscarriage for high uterine natural killer cell density and randomizing to prednisolone or placebo when pregnant

2013 ◽  
Vol 28 (7) ◽  
pp. 1743-1752 ◽  
Author(s):  
A.-W. Tang ◽  
Z. Alfirevic ◽  
M. A. Turner ◽  
J. A. Drury ◽  
R. Small ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Cell Density ◽  
Recurrent Miscarriage ◽  
Killer Cell ◽  
Feasibility Trial ◽  
Idiopathic Recurrent Miscarriage ◽  
Uterine Natural Killer

1.  Heme Oxygenase‐1 Enzyme Deficiency Affects Uterine Natural Killer Cell Function During Murine Pregnancy 

2017 ◽  
Author(s):  
Tracy Zhang
Keyword(s):  
Natural Killer ◽  
Heme Oxygenase ◽  
Cell Function ◽  
Recurrent Miscarriage ◽  
Embryo Implantation ◽  
Killer Cell ◽  
Implantation Site ◽  
Heme Oxygenase 1 ◽  
Unk Cells ◽  
Uterine Natural Killer

Recurrent miscarriage is a condition that affects 1% of all women, and rejection of the fetus by the mother's immune system is thought to be one of the underlying causes. The mechanisms of maternal tolerance vital to a successful pregnancy are not well understood; however, uterine natural killer (uNK) cells are implicated as they comprise over 70% of immune cells in the uterus during early pregnancy. Heme oxygenase‐1 (HO‐1) is an enzyme that is known to be immunosuppressive. Moreover, mice missing HO‐1 have extremely high abortion rates. This study is the first to analyze the effects of HO‐1 deficiency specifically on uNK cells. We posit that an absence of HO‐1 affects normal uNK cell‐mediated immunosuppression, and also possibly their ability to modify uterine spiral arteries supplying blood to the fetus. Our study analyzed embryos from mice lacking or deficient in HO‐1 on days 8, 10, and 12 of pregnancy. Both number of uNK cells and degree of vascularization were analyzed using immunohistochemistry staining. We observed a significantly higher number of uNK cells in one area of the embryo implantation site and a significantly lower number of cells in another, suggesting the uNK cells are failing to localize properly. Analysis of vascularization is currently ongoing. Since women with multiple miscarriages have been shown to down‐regulate HO‐1, confirmation that absence of HO‐1 leads to implantation site abnormalities could pave the way for future clinical treatments.  

Natural killer cell activity in women with recurrent miscarriage

2016 ◽  
Vol 118 ◽  
pp. 132 ◽  
Author(s):  
Yasuhiko Ebina ◽  
Yukari Nishino ◽  
Masashi Deguchi ◽  
Yoko Maesawa ◽  
Yuki Nakajima ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Recurrent Miscarriage ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity ◽  
Killer Cell Activity
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