scholarly journals The role of carbohydrate recognition during human sperm-egg binding

2013 ◽  
Vol 28 (3) ◽  
pp. 566-577 ◽  
Author(s):  
G. F. Clark
Keyword(s):  
Human Sperm ◽  
Carbohydrate Recognition

The Role of Epididymal Factors in Human Sperm Fertilizing Ability

1988 ◽  
Vol 541 (1 In Vitro Fert) ◽  
pp. 292-296 ◽  
Author(s):  
J. A. BLAQUIER ◽  
M. S. CAMEO ◽  
P. S. CUASNICU ◽  
M. F. GONZALEZ ECHEVERRIA ◽  
L. PINUEIRO ◽  
...  
Keyword(s):  
Human Sperm ◽  
Fertilizing Ability ◽  
Sperm Fertilizing Ability

scholarly journals 436. Investigation of the role of SRC in capacitation associated tyrosine phosphorylation of human spermatozoa

2008 ◽  
Vol 20 (9) ◽  
pp. 116
Author(s):  
L. A. Mitchell ◽  
B. Nixon ◽  
M. A. Baker ◽  
R. J. Aitken
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Phosphorylation ◽  
Signal Transduction Pathway ◽  
Human Sperm ◽  
Complex Signal ◽  
Phosphorylation Cascade ◽  
A Site ◽  
Signalling Cascade ◽  
Mammalian Spermatozoa

Capacitation is a pre-requisite for mammalian spermatozoa allowing them to gain the ability to fertilise an oocyte. A fundamental part of this mechanism is a dramatic increase in tyrosine phosphorylation. Implicated in this process in the mouse is a unique cAMP/PKA-mediated pathway involving a PKA-activated tyrosine kinase suggested to be pp60c-src (SRC). The Src kinases examined were predominantly expressed in the human sperm tail, a site compatible with a role in mediating the capacitation-associated tyrosine phosphorylation cascade. Co-immunoprecipitation revealed that PKA-c could be isolated from sperm and this interaction was restricted to capacitated cells, suggesting PKA-mediated activation of SRC forms an integral part of the signalling cascade assembled during capacitation. Upon activation, SRC undergoes autophosphorylation of Y416 and thus phosphorylation of this residue indicates the presence of active SRC kinase. The phosphorylation status of SRC was compared using both 2D-immunoblotting and immunocytochemical studies, both revealing a significant increase in SRC activation during capacitation. Furthermore, suppression of PKA and SRC through application of SU6656, or H89, a PKA inhibitor, led to a dramatic decrease in tyrosine phosphorylation and SRC activity. In conclusion, this study has provided evidence for the involvement of non-receptor tyrosine kinase, SRC, in regulating tyrosine phosphorylation associated with capacitation. Inhibition of SRC did not completely suppress tyrosine phosphorylation suggesting this complex signal transduction pathway exhibits a degree of functional redundancy.

scholarly journals Role of C-type natriuretic peptide in the function of normal human sperm

2016 ◽  
Vol 18 (1) ◽  
pp. 80 ◽  
Author(s):  
Dong-Hui Huang ◽  
Hui Xia ◽  
Yao Chen ◽  
Ke-Jia Wu ◽  
Hu Zhao ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Human Sperm ◽  
Normal Human

1141651467 Role of calpain in human sperm

2006 ◽  
Vol 55 (6) ◽  
pp. 411-411
Author(s):  
Y Ozaki ◽  
S Goto ◽  
K Nozawa ◽  
T Nakanishi ◽  
M Sugiura
Keyword(s):  
Human Sperm

scholarly journals Relevance of Fatty Acids to Sperm Maturation and Quality

2020 ◽  
Vol 2020 ◽  
pp. 1-14 ◽  
Author(s):  
Giulia Collodel ◽  
Cesare Castellini ◽  
Jetty Chung-Yung Lee ◽  
Cinzia Signorini
Keyword(s):  
Biological Sciences ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Profile ◽  
Human Sperm ◽  
Dietary Fatty Acids ◽  
Pathological Conditions ◽  
Sperm Membrane ◽  
And Function

Almost 50% of infertility cases are associated with human male infertility. The sperm membrane is a key structure influencing sperm morphology and function in normal and pathological conditions. The fatty acid profile determines the performance not only of sperm motility but also of acrosomal reaction and sperm-oocyte fusion. This review presents available knowledge on the role of fatty acid composition in human sperm and spermatogenesis and discusses the influence of dietary fatty acids on the sperm fatty acid profile. Recent studies in biological sciences and clinical researches in this field are also reported. The topic object of this review has potential application in medicine by identifying potential causes of infertility.

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