scholarly journals Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women

2012 ◽  
Vol 27 (12) ◽  
pp. 3569-3576 ◽  
Author(s):  
M. A. Martinez-Garcia ◽  
A. Gambineri ◽  
M. Alpanes ◽  
R. Sanchon ◽  
R. Pasquali ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Common Variants ◽  
Hormone Binding ◽  
Ovary Syndrome ◽  
Globulin Gene

Common Variants in the Sex Hormone-Binding Globulin (SHBG) Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome

2015 ◽  
Vol 68 (1) ◽  
pp. 66-74 ◽  
Author(s):  
Tala M. Abu-Hijleh ◽  
Emily Gammoh ◽  
Amna S. Al-Busaidi ◽  
Zainab H. Malalla ◽  
Samira Madan ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Multivariate Regression Analysis ◽  
Sex Hormone ◽  
Minor Allele ◽  
Sex Hormone Binding Globulin ◽  
Common Variants ◽  
Hormone Binding ◽  
Ovary Syndrome ◽  
Reduced Frequency

Background: Decreased sex hormone-binding globulin (SHBG) levels were associated with polycystic ovary syndrome (PCOS). SHBG polymorphisms associated with reduced SHBG production were tested for their association with PCOS, but with inconclusive results. We tested whether altered SHBG levels and SHBG variants were associated with PCOS. Methods: The study subjects included 242 women with PCOS and 238 control women. SHBG genotyping was done by real-time PCR. Results: Higher minor allele frequency of rs13894, rs858521 and rs727428 was seen in PCOS cases, and significant differences in rs858521 and rs727428 genotypes distribution were seen between PCOS cases and controls. Multivariate regression analysis confirmed the association of only rs727428 with PCOS. Though it was not statistically significant, serum SHBG levels were reduced according to rs727428 genotypes in PCOS cases than in controls. Carriage of rs727428 minor allele was associated with significant increases in free/bioactive testosterone in PCOS cases. Seven-locus (rs9898876-rs13894-rs858521-rs1799941-rs6257-rs6259-rs727428) haploview analysis showed increased frequency of GCCGTGA, GTCGTGA and GTCATGG, and reduced frequency of GTCGTGG haplotypes in PCOS cases than in controls, thus conferring disease susceptibility and protective nature to these haplotypes, respectively. Conclusion: Specific SHBG variants affecting serum SHBG levels and SHBG haplotypes are associated with PCOS, suggesting the role for SHBG as PCOS candidate gene.

Role of D327N sex hormone-binding globulin gene polymorphism in the pathogenesis of polycystic ovary syndrome

2007 ◽  
Vol 104 (1-2) ◽  
pp. 68-74 ◽  
Author(s):  
Běla Bendlová ◽  
Jana Zavadilová ◽  
Markéta Vaňková ◽  
Daniela Vejražková ◽  
Petra Lukášová ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Gene Polymorphism ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Ovary Syndrome ◽  
Globulin Gene

A Direct Effect of Hyperinsulinemia on Serum Sex Hormone-Binding Globulin Levels in Obese Women with the Polycystic Ovary Syndrome*

1991 ◽  
Vol 72 (1) ◽  
pp. 83-89 ◽  
Author(s):  
JOHN E. NESTLER ◽  
LINDA P. POWERS ◽  
DENNIS W. MATT ◽  
KENNETH A. STEINGOLD ◽  
STEPHEN R. PLYMATE ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Direct Effect ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Obese Women ◽  
Hormone Binding ◽  
Ovary Syndrome

Sex hormone-binding globulin expression in the endometria of women with polycystic ovary syndrome

2007 ◽  
Vol 87 (2) ◽  
pp. 321-328 ◽  
Author(s):  
Manuel Maliqueo ◽  
Ketty Bacallao ◽  
Susana Quezada ◽  
Marisa Clementi ◽  
Fernando Gabler ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Ovary Syndrome

Sex hormone-binding globulin and polycystic ovary syndrome

2019 ◽  
Vol 499 ◽  
pp. 142-148 ◽  
Author(s):  
Jing-ling Zhu ◽  
Zhuo Chen ◽  
Wen-jie Feng ◽  
Shuang-lian Long ◽  
Zhong-Cheng Mo
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Ovary Syndrome
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