scholarly journals Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the Generation R Study

2012 ◽  
Vol 27 (4) ◽  
pp. 1191-1201 ◽  
Author(s):  
C. A. Snijder ◽  
A. Kortenkamp ◽  
E. A. P. Steegers ◽  
V. W. V. Jaddoe ◽  
A. Hofman ◽  
...  
Keyword(s):  
Intrauterine Exposure ◽  
Mild Analgesics

scholarly journals Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat

2010 ◽  
Vol 26 (1) ◽  
pp. 235-244 ◽  
Author(s):  
David Møbjerg Kristensen ◽  
Ulla Hass ◽  
Laurianne Lesné ◽  
Grete Lottrup ◽  
Pernille Rosenskjold Jacobsen ◽  
...  
Keyword(s):  
Risk Factor ◽  
Reproductive Disorders ◽  
Intrauterine Exposure ◽  
Mild Analgesics

Analgesic Efficacy of Dextropropoxyphene and Dextropropoxyphene-containing Combinations: a Review

1984 ◽  
Vol 3 (1_suppl) ◽  
pp. 191s-220S ◽  
Author(s):  
W.T. Beaver
Keyword(s):  
Clinical Trial ◽  
Analgesic Efficacy ◽  
Controlled Clinical Trial ◽  
Controlled Clinical Trials ◽  
Congressional Hearings ◽  
Clinical Assay ◽  
The Subject ◽  
Minimum Criteria ◽  
Oral Doses ◽  
Mild Analgesics

Twenty years ago, as part of a review of the clinical pharmacology of mild analgesics (Beaver, 1965, 1966), I evaluated reports of those analgesic trials of dextropropoxyphene that appeared to satisfy the minimum methodologic requirements for a controlled clinical trial of analgesic efficacy. On reviewing reports of studies that have been published since then, I find little need to modify my evaluation of the efficacy of dextropropoxyphene that appeared in 1966, at least in respect to the effect of single oral doses: In summary, dextropropoxyphene (hydrochloride) is a mild oral analgesic which has proven superior to placebo in doses of 65 mg or more but which is of questionable efficacy in doses lower than 65 mg. The drug is definitely less potent than codeine: the best available estimates of the relative potency of the two drugs indicating that dextropropoxyphene is approximately 1/2-2/3 as potent. Likewise, dextropropoxyphene in 32-65 mg doses is certainly no more, and possibly less, effective than the usually used doses of aspirin or A.P.C. (aspirin/phenacetin/caffeine). In the interim, the efficacy of dextropropoxyphene has been the subject of a number of other critical reviews (Miller et al., 1970; Miller, 1977), commentaries (Kiplinger & Nickander, 1971; Lasagna, 1976), and even congressional hearings (Beaver, 1979; Moertel, 1979). More importantly, new controlled clinical trials involving dextropropoxyphene hydrochloride or napsylate have been reported, and some of these use more sophisticated design and analysis than those available in 1966. I will therefore discuss the results of those newer studies of apparently suitable scientific design that meet at least the minimum criteria for a valid clinical assay of analgesic activity (Beaver, 1965; Houde et al., 1965,1966; Wallenstein & Houde, 1975; Beaver, 1983), and I will comment on only a few of the studies included in my previous review (Beaver, 1966).

Intrauterine Exposure to Tobacco and Risk of Medically Indicated and Spontaneous Preterm Birth

2009 ◽  
Vol 27 (05) ◽  
pp. 405-410 ◽  
Author(s):  
Muktar Aliyu ◽  
O'Neil Lynch ◽  
Rakiya Saidu ◽  
Amina Alio ◽  
Phillip Marty ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Spontaneous Preterm Birth ◽  
Intrauterine Exposure

Exposure of human fetal kidneys to mild analgesics interferes with early nephrogenesis

2021 ◽  
Vol 35 (7) ◽  
Author(s):  
Sabrina Leverrier‐Penna ◽  
Alain Michel ◽  
Laetitia L. Lecante ◽  
Nathalie Costet ◽  
Antonio Suglia ◽  
...  
Keyword(s):  
Mild Analgesics

scholarly journals Letter: vedolizumab drug concentrations in neonates following intrauterine exposure

2018 ◽  
Vol 48 (11-12) ◽  
pp. 1328-1330 ◽  
Author(s):  
Emma Flanagan ◽  
Peter R. Gibson ◽  
Jakob Begun ◽  
Simon Ghaly ◽  
Mayur Garg ◽  
...  
Keyword(s):  
Intrauterine Exposure ◽  
Drug Concentrations

Successful Use of a Moderate Analgesic (Fortagesic) in the Symptomatic Treatment of Osteoarthritis

1979 ◽  
Vol 7 (1) ◽  
pp. 77-82
Author(s):  
G I Rooney
Keyword(s):  
Controlled Trial ◽  
Symptomatic Treatment ◽  
Anti Inflammatory ◽  
Mild Analgesics ◽  
Single Blind

In a between-patient single blind controlled trial, two groups of patients with osteoarthritis were treated for two weeks with either Fortagesic or naproxen tablets. Onset of analgesia was significantly more rapid with Fortagesic than with naproxen. Other assessments favoured Fortagesic but the differences were not statistically significant. It is concluded that Fortagesic can be successfully used to fill the gap between mild analgesics and the anti-inflammatory agents in the symptomatic treatment of osteoarthritis.

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