scholarly journals Monitoring of ovarian activity by measurement of urinary excretion rates of estrone glucuronide and pregnanediol glucuronide using the Ovarian Monitor, Part II: reliability of home testing

2011 ◽  
Vol 27 (2) ◽  
pp. 550-557 ◽  
Author(s):  
L. F. Blackwell ◽  
P. Vigil ◽  
B. Gross ◽  
C. d'Arcangues ◽  
D. G. Cooke ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Ovarian Activity ◽  
Home Testing ◽  
Excretion Rates

Urinary 5-HIAA Excretion is not Increased in Patients with Head and Neck Paragangliomas

2012 ◽  
Vol 27 (2) ◽  
pp. 160-163 ◽  
Author(s):  
Leonie T. Van Hulsteijn ◽  
Nicolette Van Duinen ◽  
Johannes A. Romijn ◽  
Johannes W.A. Smit ◽  
Eleonora P.M. Corssmit
Keyword(s):  
Urinary Excretion ◽  
Head And Neck ◽  
Reference Range ◽  
Excretion Rate ◽  
Case Reports ◽  
Catecholamine Excess ◽  
Hydroxyindoleacetic Acid ◽  
Excretion Rates ◽  
Almost All ◽  
Head And Neck Paragangliomas

Background Case reports have documented carcinoid-like features in head and neck paragangliomas (HNPGLs), which, in addition to catecholamine storing granules, may also contain granules with serotonin. Serotonin is metabolized to 5-hydroxyindoleacetic acid (5-HIAA). Aim To assess the urinary excretion rates of 5-HIAA and catecholamines in HNPGL patients. Methods In 114 consecutive HNPGL patients, normetanephrine, metanephrine, norepinephrine, epinephrine, VMA, dopamine, 3-methoxytyramine and 5-HIAA excretion rates were measured in two 24-hour urinary samples. Increased excretion rates were defined as an increase of the average hormone excretion rate of 2 urine samples above the reference range. In all patients with catecholamine excess, intrathoracic and abdominal paragangliomas were excluded by 123I-MIBG scintigraphy, MRI and/or CT. Genetic screening for mutations in genes of the succinate dehydrogenase (SDH) family was performed. Results Mean urinary 5-HIAA excretion rate was 14±9 μmol/24 hours (reference range 10–44 μmol/24 hours). Urinary 5-HIAA excretion was slightly increased in only 1 patient (48 μmol/24 hours). None of the 50 patients (44%) with increased urinary excretion rates of catecholamines and/or their metabolites had elevated 5-HIAA excretion. Conclusion Urinary 5-HIAA excretion is within the normal reference range in almost all HNPGL patients. Therefore, this parameter has no clinical relevance in the routine clinical assessment of HNPGL patients.

scholarly journals Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality

Amino Acids ◽  
2021 ◽  
Author(s):  
Svetlana Baskal ◽  
Adrian Post ◽  
Daan Kremer ◽  
Alexander Bollenbach ◽  
Stephan J. L. Bakker ◽  
...  
Keyword(s):  
Amino Acids ◽  
Urinary Excretion ◽  
Excretion Rate ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
All Cause Mortality ◽  
Excretion Rates

AbstractArginine (Arg) and lysine (Lys) moieties of proteins undergo various post-translational modifications (PTM) including enzymatic NG- and Nε-methylation and non-enzymatic NG- and Nε-glycation. In a large cohort of stable kidney transplant recipients (KTR, n = 686), high plasma and low urinary concentrations of asymmetric dimethylarginine (ADMA), an abundant PTM metabolite of Arg, were associated with cardiovascular and all-cause mortality. Thus, the prediction of the same biomarker regarding mortality may depend on the biological sample. In another large cohort of stable KTR (n = 555), higher plasma concentrations of Nε-carboxymethyl-lysine (CML) and Nε-carboxyethyl-lysine (CEL), two advanced glycation end-products (AGEs) of Lys, were associated with higher cardiovascular mortality. Yet, the associations of urinary AGEs with mortality are unknown. In the present study, we measured 24 h urinary excretion of Lys, CML, and furosine in 630 KTR and 41 healthy kidney donors before and after donation. Our result indicate that lower urinary CML and lower furosine excretion rates are associated with higher mortality in KTR, thus resembling the associations of ADMA. Lower furosine excretion rates were also associated with higher cardiovascular mortality. The 24 h urinary excretion rate of amino acids and their metabolites decreased post-donation (varying as little as − 24% for CEL, and as much as − 62% for ADMA). For most amino acids, the excretion rate was lower in KTR than in donors pre-donation [except for S-(1-carboxyethyl)-l-cysteine (CEC) and NG-carboxyethylarginine (CEA)]. Simultaneous GC–MS measurement of free amino acids, their PTM metabolites and AGEs in urine is a non-invasive approach in kidney transplantation.

Urinary excretion rates of 8-oxoGua and 8-oxodG and antioxidant vitamins level as a measure of oxidative status in healthy, full-term newborns

2007 ◽  
Vol 41 (9) ◽  
pp. 997-1004 ◽  
Author(s):  
Tomasz Dziaman ◽  
Daniel Gackowski ◽  
Rafal Rozalski ◽  
Agnieszka Siomek ◽  
Jaroslaw Szulczynski ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Oxidative Status ◽  
Full Term ◽  
Antioxidant Vitamins ◽  
Term Newborns ◽  
Excretion Rates

Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats

2006 ◽  
Vol 291 (5) ◽  
pp. H2166-H2172 ◽  
Author(s):  
Jewell A. Jessup ◽  
Patricia E. Gallagher ◽  
David B. Averill ◽  
K. Bridget Brosnihan ◽  
E. Ann Tallant ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Urinary Excretion ◽  
Renin Angiotensin System ◽  
Ace Inhibition ◽  
Mean Difference ◽  
Transgenic Rat ◽  
Original Strain ◽  
Ang Ii ◽  
Protein Activity ◽  
Excretion Rates

The generation of the Lew.Tg( mRen2) congenic hypertensive rat strain, developed through a backcross of the hypertensive (mRen2)27 transgenic rat with normotensive Lewis rats, provides a new model by which primary hypertension can be studied without the genetic variability found in the original strain. The purpose of this study was to characterize the Lew.Tg( mRen2) rats by dually investigating the effects of type 1 angiotensin II (ANG II) receptor (AT1) blockade and angiotensin-converting enzyme (ACE) activity inhibition on the ANG-(1–7)/ACE2 axis of the renin-angiotensin system in this new hypertensive model. The control of blood pressure elicited by 12-day administration of either lisinopril (mean difference change = 92 ± 2, P < 0.05) or losartan (mean difference change = 69 ± 2, P < 0.05) was associated with 54% and 33% increases in cardiac ACE2 mRNA and 54% and 43% increases in cardiac ACE mRNA, respectively. Lisinopril induced a 3.1-fold ( P < 0.05) increase in renal cortical expression of ACE2, whereas losartan increased ACE2 mRNA 3.5-fold ( P < 0.05). Both treatment regimens increased renal ACE mRNA 2.6-fold ( P < 0.05). The two therapies augmented ACE2 protein activity, as well as increased cardiac and renal AT1 receptor mRNAs. ACE inhibition reduced plasma ANG II levels (81%, P < 0.05) and increased plasma ANG-(1–7) (265%, P < 0.05), whereas losartan had no effect on the peptides. In contrast with what had been shown in normotensive rats, ACE inhibition decreased renal ANG II excretion and transiently decreased ANG-(1–7) excretion, whereas losartan treatment was associated with a consistent decrease in ANG-(1–7) urinary excretion rates. In response to the treatments, the expression of both renal cortical renin and angiotensinogen mRNAs was significantly augmented. The paradoxical effects of blockade of ANG II synthesis and activity on urinary excretion rates of the peptides and plasma angiotensins levels suggest that, in Lew.Tg( mRen2) congenic rats, a failure of compensatory ACE2 and ANG-(1–7)-dependent vasodepressor mechanisms may contribute both to the development and progression of hypertension driven by increased formation of endogenous ANG II.

scholarly journals Time Pattern of Vitamin B12Co60 Urinary Excretion in Man After Oral Administration and Parenteral "Flushing"

Blood ◽  
1956 ◽  
Vol 11 (4) ◽  
pp. 352-356 ◽  
Author(s):  
WILLIAM R. BEST ◽  
WENDELL A. LANDMANN ◽  
LOUIS R. LIMARZI
Keyword(s):  
Oral Dose ◽  
Oral Administration ◽  
Urinary Excretion ◽  
Pernicious Anemia ◽  
Intrinsic Factor ◽  
Time Pattern ◽  
Number Of Patients ◽  
Excretion Rates ◽  
The Individual ◽  
Factor Concentrate

Abstract Serial urine collections in a number of patients with pernicious anemia given 2 µg B12Co60 orally followed in two hours by 1000 µg nonradioactive vitamin B12 showed little urinary radioactivity at any time. When these tests were repeated together with a potent oral dose of intrinsic factor concentrate, there was little activity during the first four hours. Peak excretion rates occurred most commonly between 6 and 12 hours after ingestion of radioactive B12, sometimes even later. The time of peak excretion was fairly characteristic for the individual. Secondary peaks occasionally occurred, and only slight radioactivity usually remained after 24 hours. It is postulated that the delayed peak is related to the time it takes for B12 to be transported in the intestine to the point of absorption or to the duration of the intracellular metabolic processes of absorption. For most purposes the use of fractional urinary collections is not necessary.

Effects of thyroparathyroidectomy, parathyroid hormone, and PTHrP on kidneys of ovine fetuses

1993 ◽  
Vol 264 (1) ◽  
pp. E37-E44 ◽  
Author(s):  
R. J. MacIsaac ◽  
R. S. Horne ◽  
I. W. Caple ◽  
T. J. Martin ◽  
E. M. Wintour
Keyword(s):  
Parathyroid Hormone ◽  
Urinary Excretion ◽  
Excretion Rate ◽  
Plasma Concentrations ◽  
Free Water ◽  
Total Calcium ◽  
Fetal Plasma ◽  
Parathyroid Hormone Related Protein ◽  
Fetal Urine ◽  
Excretion Rates

The fetal parathyroid glands and parathyroid hormone-related protein (PTHrP) have been shown to be important regulators of fetal calcium metabolism through their actions on the placenta and bone. This study examined the effects of fetal thyroparathyroidectomy (with thyroxine replacement) and exogenous infusion of human parathyroid hormone [PTH-(1–34)], PTHrP-(1–34), and PTHrP-(1–141) on the urinary excretion of calcium in chronically cannulated ovine fetuses during the last one-fifth of gestation. Fetal plasma total and ionized calcium concentrations were significantly lower in thyroparathyroidectomized (TxPTx) fetuses when compared with intact fetuses, but there were no significant differences in urinary excretion rates of total calcium. However, TxPTx produced a significant increase in the fractional excretion rate of total calcium and a significant decrease in the excretion of adenosine 3',5'-cyclic monophosphate (cAMP) compared with intact fetuses. Infusions of PTH-(1–34), PTHrP-(1–34), and PTHrP-(1–141) into the jugular vein of TxPTx fetuses (n = 5) at the rate of 1 nmol/h for 2 h, after a 1-nmol loading dose, significantly decreased the excretion rate of total calcium and increased the excretion rate of cAMP in fetal urine. Infusions of all three peptides resulted in significant increases in the concentration of total calcium in fetal plasma but had no effect on the plasma concentrations or urinary excretion rates of phosphate. Infusion of either PTH-(1–34), PTHrP-(1–34), or PTHrP-(1–141) also resulted in an increase in fetal urine osmolality and pH and a decrease in free water clearance in TxPTx fetuses.(ABSTRACT TRUNCATED AT 250 WORDS)

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