scholarly journals Establishment and characterization of a spontaneously immortalized trophoblast cell line (HPT-8) and its hepatitis B virus-expressing clone

2011 ◽  
Vol 26 (8) ◽  
pp. 2146-2156 ◽  
Author(s):  
Lei Zhang ◽  
Weilu Zhang ◽  
Chen Shao ◽  
Jingxia Zhang ◽  
Ke Men ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cell Line ◽  
Trophoblast Cell ◽  
B Virus ◽  
Trophoblast Cell Line

scholarly journals Molecular characterization of hepatitis B virus genotypes in Uzbekistan

2020 ◽  
Vol 101 ◽  
pp. 511
Author(s):  
M. Abdukadirova ◽  
A. Khikmatullaeva ◽  
N. Ibadullaeva ◽  
S. Bakieva
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Molecular Characterization ◽  
B Virus ◽  
Virus Genotypes

scholarly journals Functional Characterization of Interferon Regulation Element of Hepatitis B virus Genome In Vivo

2012 ◽  
Vol 23 (3) ◽  
pp. 278-285 ◽  
Author(s):  
Feng-Jun Liu ◽  
En-Qiang Chen ◽  
Qiao-Ling Zhou ◽  
Tao-You Zhou ◽  
Cong Liu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Functional Characterization ◽  
Virus Genome ◽  
B Virus

scholarly journals Creation of a Six-fingered Artificial Transcription Factor That Represses the Hepatitis B Virus HBx Gene Integrated into a Human Hepatocellular Carcinoma Cell Line

2012 ◽  
Vol 18 (4) ◽  
pp. 378-387 ◽  
Author(s):  
Xinghui Zhao ◽  
Zhanzhong Zhao ◽  
Junwei Guo ◽  
Peitang Huang ◽  
Xudong Zhu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcription Factor ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cell Line ◽  
Hbv Infection ◽  
Luciferase Reporter ◽  
Artificial Transcription Factor ◽  
Chronic Hepatitis B Virus ◽  
B Virus

Chronic hepatitis B virus (HBV) infection is an independent risk factor for the development of hepatocellular carcinoma (HCC). The HBV HBx gene is frequently identified as an integrant in the chromosomal DNA of patients with HCC. HBx encodes the X protein (HBx), a putative viral oncoprotein that affects transcriptional regulation of several cellular genes. Therefore, HBx may be an ideal target to impede the progression of HBV infection–related HCC. In this study, integrated HBx was transcriptionally downregulated using an artificial transcription factor (ATF). Two three-fingered Cys2-His2 zinc finger (ZF) motifs that specifically recognized two 9-bp DNA sequences regulating HBx expression were identified from a phage-display library. The ZF domains were linked into a six-fingered protein that specified an 18-bp DNA target in the Enhancer I region upstream of HBx. This DNA-binding domain was fused with a Krüppel-associated box (KRAB) transcriptional repression domain to produce an ATF designed to downregulate HBx integrated into the Hep3B HCC cell line. The ATF significantly repressed HBx in a luciferase reporter assay. Stably expressing the ATF in Hep3B cells resulted in significant growth arrest, whereas stably expressing the ATF in an HCC cell line lacking integrated HBx (HepG2) had virtually no effect. The targeted downregulation of integrated HBx is a promising novel approach to inhibiting the progression of HBV infection–related HCC.

scholarly journals Characterization of antiviral resistance mutations among the Eastern Indian Hepatitis B virus infected population

2013 ◽  
Vol 10 (1) ◽  
pp. 56 ◽  
Author(s):  
Rajesh Panigrahi ◽  
Avik Biswas ◽  
Binay Krishna De ◽  
Sekhar Chakrabarti ◽  
Runu Chakravarty
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antiviral Resistance ◽  
Resistance Mutations ◽  
Infected Population ◽  
B Virus

scholarly journals Production of hepatitis B virus in vitro by transient expression of cloned HBV DNA in a hepatoma cell line.

1987 ◽  
Vol 6 (3) ◽  
pp. 675-680 ◽  
Author(s):  
C.M. Chang ◽  
K.S. Jeng ◽  
C.P. Hu ◽  
S.J. Lo ◽  
T.S. Su ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cell Line ◽  
Transient Expression ◽  
Hepatoma Cell ◽  
Hbv Dna ◽  
Hepatoma Cell Line ◽  
B Virus

Characterization of a novel hepatitis B virus subgenotype B10 among chronic hepatitis B patients in Yunnan, China

2020 ◽  
Vol 83 ◽  
pp. 104322
Author(s):  
Ying Liu ◽  
Yue Feng ◽  
Yaling Li ◽  
Jing Ma ◽  
Yuanyuan Jia ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
B Virus

Cloning and characterization of cDNAs coding for heavy and light chains of a monoclonal antibody specific for the S antigen of hepatitis B virus

Gene ◽  
1994 ◽  
Vol 144 (2) ◽  
pp. 313-314 ◽  
Author(s):  
Ryu Chun Jeih ◽  
Jin Byung Rae ◽  
Chung Hong Keun ◽  
Han Moon Hi ◽  
Hong Hyo Jeong
Keyword(s):  
Monoclonal Antibody ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Light Chains ◽  
B Virus
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