scholarly journals Comparison of inhibin B and estradiol responses to intravenous FSH in women with polycystic ovary syndrome and normal women

2009 ◽  
Vol 25 (1) ◽  
pp. 198-203 ◽  
Author(s):  
M. A. Rosencrantz ◽  
D. S. Wachs ◽  
M. S. Coffler ◽  
P. J. Malcom ◽  
M. Donohue ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Inhibin B ◽  
Ovary Syndrome ◽  
Normal Women

scholarly journals Decreased inhibin B responses following recombinant human chorionic gonadotropin administration in normal women and women with polycystic ovary syndrome

2014 ◽  
Vol 101 (1) ◽  
pp. 275-279 ◽  
Author(s):  
Rana F. Shayya ◽  
Marcus A. Rosencrantz ◽  
Sandy S. Chuan ◽  
Heidi Cook-Andersen ◽  
William E. Roudebush ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Polycystic Ovary ◽  
Inhibin B ◽  
Ovary Syndrome ◽  
Normal Women

scholarly journals Comparison of Follicle-Stimulating-Hormone-Stimulated Dimeric Inhibin and Estradiol Responses as Indicators of Granulosa Cell Function in Polycystic Ovary Syndrome and Normal Women

2006 ◽  
Vol 91 (8) ◽  
pp. 2920-2925 ◽  
Author(s):  
Deborah S. Wachs ◽  
Mickey S. Coffler ◽  
Pamela J. Malcom ◽  
R. Jeffrey Chang
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Granulosa Cell ◽  
Functional Capacity ◽  
Cell Function ◽  
Polycystic Ovary ◽  
Academic Medical Center ◽  
Inhibin B ◽  
Ovary Syndrome ◽  
Inhibin A ◽  
Normal Women

Abstract Context: Follicular phase secretion of inhibin B, like that of estradiol (E2), correlates with the quantity and quality of developing follicles. However, it has not been established whether inhibin B responses to gonadotropin stimulation parallel those of E2 as a reflection of granulosa cell functional capacity. Objective: Our objective was to determine whether inhibin B responses to FSH stimulation are similar to those of E2 in women with polycystic ovary syndrome (PCOS) and normal women. Design and Setting: We conducted a prospective study to compare ovarian responses in two groups of women at a general clinical research center in a tertiary academic medical center. Patients: Women with PCOS, 18–35 yr (n = 19), and normal ovulatory controls, 18–35 yr (n = 7), were recruited for study. Interventions: Serum samples were measured over a 24-h period after an iv injection of recombinant human FSH, 150 IU. Main Outcome Measures: Serum E2, inhibin A, and inhibin B responses after FSH administration were assessed. Results: In PCOS women, the 24-h production of inhibin B and E2 after FSH was significantly greater than that of normal controls. Within the PCOS group, the fold change in inhibin B was significantly greater than that of E2. Inhibin A responses between groups were similar and of markedly lower magnitude. Conclusions: FSH-stimulated inhibin B responses may be employed to assess the functional capacity of granulosa cells in PCOS and normal women.

scholarly journals Mucin-1 expression in endometrium is higher in polycystic ovary syndrome than in normal women

2020 ◽  
Vol 39 (2) ◽  
pp. 74
Author(s):  
Uki Retno Budihastuti ◽  
Sri Sulistyowati ◽  
Eriana Melinawati ◽  
Yohan Pamuji Marbun
Keyword(s):  
Linear Regression ◽  
Polycystic Ovary Syndrome ◽  
Life Style ◽  
Polycystic Ovary ◽  
Endometrial Biopsy ◽  
Age At Menarche ◽  
Mucin 1 ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Normal Women

Background<br />The polycystic ovary syndrome (PCOS) is caused by endocrine system dysfunction in women. MUCIN-1 (MUC-1) expression is found in endometrial tissues, which leads to implantation process dysfunction because of imbalance of trophoblast adhesion process. This study was conducted to compare endometrial MUC-1 expression between PCOS and normal women considering all existing external variables.<br /><br />Methods<br />This cross-sectional study was conducted in General Hospital Dr. Moewardi Surakarta. Endometrial samples were obtained from 30 infertile PCOS women based on Rotterdam criteria, and 30 normal women. Life style and reproductive data such as age, menstrual problems, menstrual cycle, age at menarche, and BMI were collected. Subjects underwent endometrial biopsy in luteinizing hormone (LH) secretion phase LH + 5 days to LH + 10 days for immunohistochemistry (IHC) of MUC-1 expression. An independent-t and multiple linear regression test were used to analyze the data at significance level of p&lt;0.05. <br /><br />Results<br />Mean MUC-1 expression in the PCOS endometrium (49.66 ± 47.79) was significantly higher than in normal women (7.66 ± 14.55) (p=0.03). Multivariate linear regression model of life style and reproductive variables with MUC-1 showed that PCOS (b=29.54; 95% CI 9.57-49.49; p=0.004) and BMI (b= 29.99; 95% CI 5.91-54.07; p=0.001) significantly increase MUC-1 expression. PCOS (Beta=0.37) was more important than BMI (Beta=0.30) in increasing the MUC-1 expression. <br /><br />Conclusion<br />Expression of MUC-1 levels in the PCOS endometrium was higher than in normal women. This suggests that MUC-1 contributes to the unexplained reproductive failure in PCOS.

scholarly journals Polycystic Ovarian Morphology in Normal Women Does Not Predict the Development of Polycystic Ovary Syndrome

2006 ◽  
Vol 91 (10) ◽  
pp. 3878-3884 ◽  
Author(s):  
M. K. Murphy ◽  
J. E. Hall ◽  
J. M. Adams ◽  
H. Lee ◽  
C. K. Welt
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Outpatient Setting ◽  
Ovary Syndrome ◽  
Ovarian Morphology ◽  
Menstrual History ◽  
Irregular Menses ◽  
Normal Women ◽  
Over Time

Abstract Context: Polycystic ovarian morphology (PCOM) is present in 25% of normal women in the absence of polycystic ovary syndrome (PCOS); however, the natural history of PCOM is unknown. Objective: We hypothesized that the presence of PCOM predisposes the development of PCOS. Design: The study was a longitudinal follow-up study over 8.2 ± 5.2 yr (mean ± sd; range 1.7–17.5 yr). Setting: The study took place in an outpatient setting. Subjects: Women who took part in a previous study as a normal control and had an ultrasound examination (n = 40) participated. Intervention: Subjects underwent an interval menstrual history, physical exam, blood sampling, and repeat ultrasound in the follicular phase. Main Outcome Measure: Development of PCOS was diagnosed by irregular menses and hyperandrogenism, in the absence of other disorders. Changes in ovarian morphology over time were evaluated. Results: At the baseline visit, 23 women (57.5%) had PCOM and 17 (42.5%) had normal ovarian morphology. One subject with PCOM developed irregular menses and presumptive PCOS. Eleven subjects with PCOM no longer met the criteria for PCOM at follow-up. There was no factor that predicted the change to normal ovarian morphology at the follow-up visit. Conclusions: These data suggest that PCOM in women with regular ovulatory cycles does not commonly predispose the development of PCOS. Although it is unusual to develop PCOM if the ovaries are normal on first assessment, ovaries in women with PCOM no longer meet the criteria for PCOM in approximately half of cases over time.

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