scholarly journals Chemokine CXCL12 promotes the cross-talk between trophoblasts and decidual stromal cells in human first-trimester pregnancy

2008 ◽  
Vol 23 (12) ◽  
pp. 2669-2679 ◽  
Author(s):  
W.-H. Zhou ◽  
M.-R. Du ◽  
L. Dong ◽  
J. Yu ◽  
D.-J. Li
Keyword(s):  
Cross Talk ◽  
Stromal Cells ◽  
First Trimester ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy ◽  
Chemokine Cxcl12 ◽  
The Cross

scholarly journals Contractile Activity of Human Decidual Stromal Cells. II. Effect of Interleukin-10

2005 ◽  
Vol 90 (11) ◽  
pp. 6126-6130 ◽  
Author(s):  
Maria Kimatrai ◽  
Osmany Blanco ◽  
Raquel Muñoz-Fernández ◽  
Irene Tirado ◽  
Francisco Martin ◽  
...  
Keyword(s):  
Western Blotting ◽  
Stromal Cells ◽  
Contractile Activity ◽  
Collagen Gel ◽  
First Trimester ◽  
Interleukin 10 ◽  
Stress Fibers ◽  
Cell Contractility ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy

Abstract Context: Human decidual stromal cells (DSC) are myofibroblast-like cells that express α-smooth muscle (α-SM) actin, a protein associated with cell contractility. Several lines of experimental evidence in humans and mice show that antiinflammatory cytokines favor normal pregnancy, whereas Th1 and inflammatory cytokines play a role in abortion. We previously demonstrated that IL-2, a Th1 cytokine, increased the contractility of human DSC. Objective: We studied the effect of the antiinflammatory cytokines IL-10 and IL-4 on the contractility of DSC from first-trimester pregnancy. Setting and Patients: We studied 10 healthy women who underwent elective vaginal termination of first-trimester pregnancy at Clínica El Sur, Málaga, and Clínica Ginegranada, Granada. Main Outcome Measure(s): After isolation of DSC, cell contractility was measured with the collagen gel contraction assay. α-SM actin was detected with Western blotting and immunofluorescence. Results: We found that IL-10, but not IL-4, increased the volume of the collagen gel matrixes in which the cytokine-treated DSC were cultured, showing that IL-10 decreased DSC contractility. By Western blotting we demonstrated that this effect was not related to an alteration in the synthesis of α-SM actin. Nevertheless, we observed by immunofluorescence microscopy that DSC treated with IL-10 exhibited stress fibers with a lower content of α-SM actin than untreated control DSC. Conclusions: IL-10 relaxes DSC by reducing the incorporation of α-SM actin into their stress fibers. This relaxing activity may be of relevance for the maintenance of pregnancy.

scholarly journals Hyaluronan-CD44 Interaction Promotes Growth of Decidual Stromal Cells in Human First-Trimester Pregnancy

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74812 ◽  
Author(s):  
Rui Zhu ◽  
Song-Cun Wang ◽  
Chan Sun ◽  
Yu Tao ◽  
Hai-Lan Piao ◽  
...  
Keyword(s):  
Stromal Cells ◽  
First Trimester ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy

The distance between the embryo and yolk sac associated with inhibin A in the first-trimester pregnancy – which is the novelty?

2019 ◽  
Vol 1 (67) ◽  
pp. 13
Author(s):  
Carmen Elena Bucuri ◽  
Răzvan  Ciortea ◽  
Andrei Mihai Malutan ◽  
Cristian Iuhaș ◽  
Maria Rada ◽  
...  
Keyword(s):  
First Trimester ◽  
Yolk Sac ◽  
Inhibin A ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy

Prognostic value of repeated serum CA 125 measurements in first trimester pregnancy

2001 ◽  
Vol 97 (2) ◽  
pp. 168-173 ◽  
Author(s):  
Torsten Schmidt ◽  
Daniel T. Rein ◽  
Dolores Foth ◽  
Hans-Walter Eibach ◽  
Christian M. Kurbacher ◽  
...  
Keyword(s):  
Prognostic Value ◽  
First Trimester ◽  
Ca 125 ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy

scholarly journals Failed first trimester pregnancy termination: Uterine anomaly as etiologic factor

1987 ◽  
Vol 15 (3) ◽  
pp. 165-170 ◽  
Author(s):  
David R. Pennes ◽  
Richard A. Bowerman ◽  
Terry M. Silver ◽  
Steven J. Smith
Keyword(s):  
Pregnancy Termination ◽  
First Trimester ◽  
Etiologic Factor ◽  
First Trimester Pregnancy ◽  
Trimester Pregnancy ◽  
Uterine Anomaly
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