scholarly journals Premature separation of sister chromatids in human male meiosis

2008 ◽  
Vol 23 (4) ◽  
pp. 982-987 ◽  
Author(s):  
L. Uroz ◽  
O. Rajmil ◽  
C. Templado
Keyword(s):  
Male Meiosis ◽  
Sister Chromatids ◽  
Human Male

scholarly journals Distinct prophase arrest mechanisms in human male meiosis

2017 ◽  
Author(s):  
Sabrina Z. Jan ◽  
Aldo Jongejan ◽  
Cindy M. Korver ◽  
Saskia K. M. van Daalen ◽  
Ans M. M. van Pelt ◽  
...  
Keyword(s):  
Genomic Stability ◽  
Male Meiosis ◽  
Type I ◽  
Type Ii ◽  
Meiotic Arrest ◽  
Homologous Chromosomes ◽  
Xy Body ◽  
Chromosome Synapsis ◽  
Human Male ◽  
Meiotic Crossover

To prevent chromosomal aberrations to be transmitted to the offspring, strict meiotic checkpoints are in place to remove aberrant spermatocytes. However, in about 1% of all males these checkpoints cause complete meiotic arrest leading to azoospermia and subsequent infertility. We here unravel two clearly distinct meiotic arrest mechanisms that act during the prophase of human male meiosis. Type I arrested spermatocytes display severe asynapsis of the homologous chromosomes, disturbed XY-body formation and increased expression of the Y-chromosome encoded gene ZFY and seem to activate a DNA damage pathway leading to induction of p63 mediated spermatocyte elimination. Type II arrested spermatocytes display normal chromosome synapsis, normal XY-body morphology and meiotic crossover formation but have a lowered expression of several cell cycle regulating genes and fail to properly silence the X-chromosome encoded gene ZFX. Discovery and understanding of these meiotic arrest mechanisms increases our knowledge on how genomic stability is guarded during human germ cell development.

scholarly journals Human Male Meiosis and Sperm Aneuploidies

10.5772/34952 ◽  
2012 ◽  
Author(s):  
Maria Vera ◽  
Vanessa Peinado ◽  
Nasser Al-Asmar ◽  
Jennifer Gruhn ◽  
Lorena Rodrigo ◽  
...  
Keyword(s):  
Male Meiosis ◽  
Human Male

Identification of pachytene bivalents in human male meiosis using G-banding technique

Chromosoma ◽  
1975 ◽  
Vol 52 (3) ◽  
pp. 275-282 ◽  
Author(s):  
J. M. Luciani ◽  
Marie -R�gine Morazzani ◽  
A. Stahl
Keyword(s):  
Male Meiosis ◽  
Banding Technique ◽  
Human Male

scholarly journals Chromosome in situ suppression hybridisation in human male meiosis.

1992 ◽  
Vol 29 (2) ◽  
pp. 98-102 ◽  
Author(s):  
A S Goldman ◽  
M A Hulten
Keyword(s):  
Male Meiosis ◽  
Human Male

scholarly journals Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation.

1996 ◽  
Vol 134 (5) ◽  
pp. 1127-1140 ◽  
Author(s):  
B C Williams ◽  
M Gatti ◽  
M L Goldberg
Keyword(s):  
Chromosome Segregation ◽  
Male Meiosis ◽  
Chromosome Behavior ◽  
Bipolar Spindle ◽  
Chromosome Missegregation ◽  
Spindle Poles ◽  
Anaphase Onset ◽  
Sister Chromatids ◽  
Chromosome Separation ◽  
Meiosis I

Previous efforts have shown that mutations in the Drosophila ZW10 gene cause massive chromosome missegregation during mitotic divisions in several tissues. Here we demonstrate that mutations in ZW10 also disrupt chromosome behavior in male meiosis I and meiosis II, indicating that ZW10 function is common to both equational and reductional divisions. Divisions are apparently normal before anaphase onset, but ZW10 mutants exhibit lagging chromosomes and irregular chromosome segregation at anaphase. Chromosome missegregation during meiosis I of these mutants is not caused by precocious separation of sister chromatids, but rather the nondisjunction of homologs. ZW10 is first visible during prometaphase, where it localizes to the kinetochores of the bivalent chromosomes (during meiosis I) or to the sister kinetochores of dyads (during meiosis II). During metaphase of both divisions, ZW10 appears to move from the kinetochores and to spread toward the poles along what appear to be kinetochore microtubules. Redistributions of ZW10 at metaphase require bipolar attachments of individual chromosomes or paired bivalents to the spindle. At the onset of anaphase I or anaphase II, ZW10 rapidly relocalizes to the kinetochore regions of the separating chromosomes. In other mutant backgrounds in which chromosomes lag during anaphase, the presence or absence of ZW10 at a particular kinetochore predicts whether or not the chromosome moves appropriately to the spindle poles. We propose that ZW10 acts as part of, or immediately downstream of, a tension-sensing mechanism that regulates chromosome separation or movement at anaphase onset.

The XY bivalent in human male meiosis

1966 ◽  
Vol 30 (2) ◽  
pp. 119-123 ◽  
Author(s):  
MAJ HULTÉN ◽  
J. LINDSTEN ◽  
PEN-MING L. MING ◽  
M. FRACCARO
Keyword(s):  
Male Meiosis ◽  
Human Male ◽  
Xy Bivalent

Study of the human male meiosis

1977 ◽  
Vol 39 (2) ◽  
pp. 161-168
Author(s):  
M. L. De Torres ◽  
J. A. Abrisqueta
Keyword(s):  
Male Meiosis ◽  
Human Male

scholarly journals Crossover frequency and synaptonemal complex length: their variability and effects on human male meiosis

2006 ◽  
Vol 12 (2) ◽  
pp. 123-133 ◽  
Author(s):  
M. Codina-Pascual ◽  
M. Campillo ◽  
J. Kraus ◽  
M.R. Speicher ◽  
J. Egozcue ◽  
...  
Keyword(s):  
Synaptonemal Complex ◽  
Male Meiosis ◽  
Crossover Frequency ◽  
Human Male ◽  
Complex Length

HUMAN MALE MEIOSIS: CHROMOSOME BEHAVIOUR AT PRE-MEIOTIC AND MEIOTIC STAGES OF SPERMATOGENESIS

1971 ◽  
Vol 13 (3) ◽  
pp. 536-549 ◽  
Author(s):  
Alan McDermott
Keyword(s):  
Metaphase Chromosome ◽  
Meiotic Prophase ◽  
Male Meiosis ◽  
Chromosome Behaviour ◽  
Late Pachytene ◽  
Homologous Chromosomes ◽  
Human Male ◽  
Spermatogonial Metaphase

Normal testicular material was obtained from 53 men. The morphology and behaviour of the chromosomes during pre-meiotic and meiotic stages of spermatogenesis are described in detail. Three types of spermatogonial metaphase chromosome have been identified; they are thought to be from spermatogonia of different generations. Homologous chromosomes appear to be paired at the beginning of spermatogonial prophase, and at the onset of the meiotic prophase (leptotene). Bivalents assume a "lampbrush" appearance during mid- to late pachytene.

The Immunocytogenetics of Human Male Meiosis

2007 ◽  
pp. 115-128 ◽  
Author(s):  
Daniel Topping ◽  
Petrice Brown ◽  
Terry Hassold
Keyword(s):  
Male Meiosis ◽  
Human Male
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