scholarly journals In vivo assessment of the human sperm acrosome reaction and the expression of glycodelin-A in human endometrium after levonorgestrel-emergency contraceptive pill administration

2007 ◽  
Vol 22 (8) ◽  
pp. 2190-2195 ◽  
Author(s):  
Josiane A.A. do Nascimento ◽  
Markku Seppala ◽  
Antero Perdigão ◽  
Ximena Espejo-Arce ◽  
Maria José Munuce ◽  
...  
Keyword(s):  
Acrosome Reaction ◽  
Human Sperm ◽  
Human Endometrium ◽  
Contraceptive Pill ◽  
Emergency Contraceptive Pill ◽  
Emergency Contraceptive ◽  
Sperm Acrosome Reaction ◽  
In Vivo Assessment ◽  
Glycodelin A

scholarly journals Access to the Emergency Contraceptive Pill and Women's Reproductive Health: Evidence From Public Reform in Chile

Demography ◽  
2021 ◽  
Author(s):  
Damian Clarke ◽  
Viviana Salinas
Keyword(s):  
Reproductive Health ◽  
Health Outcomes ◽  
Well Being ◽  
Public Health Care ◽  
Data Sets ◽  
Contraceptive Pill ◽  
Emergency Contraceptive Pill ◽  
Emergency Contraceptive ◽  
Women’S Reproductive Health ◽  
Women's Reproductive Health

Abstract We examine the sharp expansion in availability of the emergency contraceptive pill in Chile following legalized access through municipal public health care centers. We study the period 2002–2016 and a broad rollout of the emergency contraceptive pill occurring between 2008 and 2011. By combining a number of administrative data sets on health outcomes and pharmaceutical use, and using event-study and difference-in-differences methods, we document that this expansion improved certain classes of women's reproductive health outcomes, notably reducing rates of abortion-related morbidity. These improvements were greater in areas of the country where the rollout of the emergency contraceptive pill was more extensive. We also document some evidence that refusal to provide the emergency contraceptive pill upon a women's request was linked with a worsening in reproductive health outcomes. These results point to the importance of contraceptive access as a determinant of women's reproductive health and well-being and relates to a growing body of work documenting the importance of women's autonomy as a determinant of health.

scholarly journals Effect of acetylcholine on the human sperm acrosome reaction.

1996 ◽  
Vol 71 ◽  
pp. 257
Author(s):  
Akira Nozawa. ◽  
Koji Ogasawara. ◽  
Satoru Kaneko. ◽  
Koichi Takeuchi ◽  
Takao Hashimoto
Keyword(s):  
Acrosome Reaction ◽  
Human Sperm ◽  
Sperm Acrosome Reaction ◽  
Sperm Acrosome

Are capacitation or calcium ion influx required for the human sperm acrosome reaction?

1994 ◽  
Vol 62 (6) ◽  
pp. 1255-1261 ◽  
Author(s):  
Peter Bielfeld ◽  
Robert A. Anderson ◽  
Steven R. Mack ◽  
Christopher J. De Jonge ◽  
Lourens J.D. Zaneveld
Keyword(s):  
Calcium Ion ◽  
Acrosome Reaction ◽  
Human Sperm ◽  
Ion Influx ◽  
Sperm Acrosome Reaction ◽  
Sperm Acrosome

scholarly journals Progesterone Triggers a Wave of Increased Free Calcium during the Human Sperm Acrosome Reaction

1997 ◽  
Vol 182 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Stanley Meizel ◽  
Kenneth O. Turner ◽  
Richard Nuccitelli
Keyword(s):  
Acrosome Reaction ◽  
Human Sperm ◽  
Free Calcium ◽  
Sperm Acrosome Reaction ◽  
Sperm Acrosome

Dynamics of human sperm acrosome reaction: relation with in vitro fertilization

1991 ◽  
Vol 55 (5) ◽  
pp. 994-999 ◽  
Author(s):  
Patrick Fénichel ◽  
Michèle Donzeau ◽  
Dariush Farahifar ◽  
Bernard Basteris ◽  
Noël Ayraud ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Acrosome Reaction ◽  
Human Sperm ◽  
Vitro Fertilization ◽  
Sperm Acrosome Reaction ◽  
Sperm Acrosome

scholarly journals Uterine flushings from women treated with levonorgestrel affect sperm functionality in vitro

Reproduction ◽  
2017 ◽  
Vol 154 (5) ◽  
pp. 607-614 ◽  
Author(s):  
Mayel Chirinos ◽  
Marta Durand ◽  
María Elena González-González ◽  
Gabriela Hernández-Silva ◽  
Israel Maldonado-Rosas ◽  
...  
Keyword(s):  
Tyrosine Phosphorylation ◽  
Emergency Contraception ◽  
Acrosome Reaction ◽  
Binding Capacity ◽  
Human Sperm ◽  
Contraceptive Efficacy ◽  
Serum Luteinizing Hormone ◽  
Emergency Contraceptive ◽  
Testosterone Derivative

Levonorgestrel (LNG), a synthetic 19 nor-testosterone derivative, is widely used for emergency contraception. It is well known that LNG prevents ovulation only when given prior to the surge of serum luteinizing hormone (LH) during the periovulatory phase of the menstrual cycle. This observation suggests that LNG, given its contraceptive efficacy, has additional effects other than those affecting ovulation. In this study, we have evaluated the effects on human sperm functionality of uterine flushings (UF) obtained from women at day LH + 1 of a control cycle (CTR-LH + 1) and after receiving LNG (LNG-LH + 1) two days before the surge of LH. Human sperm from normozoospermic donors were incubated with UF and protein tyrosine phosphorylation, sperm motility, acrosome reaction as well as zona pellucida (ZP) binding capacity were assessed. A significant decrease in total motility and tyrosine phosphorylation accompanied by an increase on spontaneous acrosome reaction was observed when sperm were incubated in the presence of LNG-LH + 1. None of these effects were mimicked by purified glycodelin A (GdA). Moreover, the addition of UF obtained during the periovulatory phase from LNG-treated women or the presence of purified GdA significantly decreased sperm-ZP binding. The data were compatible with changes affecting sperm capacitation, motility and interaction with the ZP. These results may offer evidence on additional mechanisms of action of LNG as an emergency contraceptive.

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