scholarly journals Chromosome segregation in an infertile man carrying a unique pericentric inversion, inv(21)(p12q22.3), analysed using fluorescence in situ hybridization on sperm nuclei: significance for clinical genetics. A case report

2006 ◽  
Vol 21 (8) ◽  
pp. 2052-2056 ◽  
Author(s):  
V. Malan ◽  
E. Pipiras ◽  
C. Sifer ◽  
S. Kanafani ◽  
I. Cedrin-Durnerin ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Case Report ◽  
Fluorescence In Situ Hybridization ◽  
Chromosome Segregation ◽  
Pericentric Inversion ◽  
Clinical Genetics ◽  
Sperm Nuclei

Canine Hepatitis Associated with Intrahepatic Bacteria in Three Dogs

2018 ◽  
Vol 54 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Joon Im ◽  
Derek P. Burney ◽  
Sean P. McDonough ◽  
Brigid Nicholson ◽  
Adam Eatroff ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Case Report ◽  
Fluorescence In Situ Hybridization ◽  
Antimicrobial Therapy ◽  
Granulomatous Inflammation ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Hematoxylin And Eosin ◽  
Formalin Fixed

ABSTRACT This case report describes the detection of intrahepatic bacteria in formalin-fixed paraffin-embedded histopathological sections from three dogs with neutrophilic, pyogranulomatous, or lymphoplasmacytic hepatitis and cholangiohepatitis. In each of these cases, eubacterial fluorescence in situ hybridization enabled colocalization of intrahepatic bacteria with neutrophilic and granulomatous inflammation in samples that were negative for bacteria when evaluated by routine hematoxylin and eosin histopathology augmented with histochemical stains. Positive responses to antimicrobial therapy were observed in of 2 out of 2 patients that were treated with antimicrobials. These findings suggest that eubacterial fluorescence in situ hybridization analysis of formalin-fixed paraffin-embedded histopathological sections is more sensitive than conventional histochemical stains for the diagnosis of bacteria-associated canine hepatitis.

Recurrent In Vitro Fertilization Failure Evaluated by Fluorescence In Situ Hybridization: A Case Report 1

1998 ◽  
Vol 69 (3) ◽  
pp. 558-560 ◽  
Author(s):  
M Grossmann M.S. ◽  
J.M Calafell Ph.D. ◽  
V Moreno Ph.D., ◽  
J Balasch M.D., ◽  
J.A Vanrell M.D., ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Case Report ◽  
In Vitro Fertilization ◽  
Fluorescence In Situ Hybridization ◽  
Fertilization Failure ◽  
Vitro Fertilization

Extensive cross-homology between the long and the short arm of chromosome 16 may explain leukemic inversions and translocations

Blood ◽  
1992 ◽  
Vol 79 (5) ◽  
pp. 1299-1304 ◽  
Author(s):  
JG Dauwerse ◽  
EA Jumelet ◽  
JW Wessels ◽  
JJ Saris ◽  
A Hagemeijer ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acute Leukemia ◽  
Fluorescence In Situ Hybridization ◽  
Pericentric Inversion ◽  
Repetitive Elements ◽  
Leukemic Cells ◽  
Acute Nonlymphocytic Leukemia ◽  
Chromosome 16

Abstract Specific rearrangements of chromosome 16 are well known in acute nonlymphocytic leukemia with abnormal eosinophils. While mapping cosmids relative to breakpoints in chromosome 16 in leukemic cells with fluorescence in situ hybridization (FISH), we have identified three areas of extensive cross-homology between 16p and 16q. Three cosmids among 99 tested showed two large signals on the short arm and one signal on the long arm of chromosome 16. A fourth cosmid showed mainly two signals on the short arm. With the 16p-specific cosmid we can demonstrate that the breakpoints of a pericentric inversion and a reciprocal (16;16) translocation, both of which are characteristic for acute leukemia, map to the most distal of two blocks on the short arm. We suggest that there may be at least two distinct repetitive elements specific for chromosome 16 interdigitated on 16p. The presence of a similar repeat in the short, as well as the long arm of the chromosome, may play a role in the origin of chromosome 16 rearrangements in acute leukemia.

scholarly journals Dedifferentiated Liposarcoma Arising in an Esophageal Polyp: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Jorge Torres-Mora ◽  
Ann Moyer ◽  
Mark Topazian ◽  
Jeffrey Alexander ◽  
Tsung-Teh Wu ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Case Report ◽  
Fluorescence In Situ Hybridization ◽  
Gene Amplification ◽  
Dedifferentiated Liposarcoma ◽  
Well Differentiated

Liposarcoma is one of the most common sarcomas in adults, but only rarely presents as an esophageal primary. There have been several reports of well-differentiated liposarcoma (WDL) arising in the esophagus, but we present a case of dedifferentiated liposarcoma (DL) presenting as a large esophageal polyp. We believe this is the first reported case of DL of the esophagus with morphologic evidence of both well-differentiated and dedifferentiated components. The diagnosis was confirmed by demonstration of CPM gene amplification by fluorescence in situ hybridization (FISH).

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