scholarly journals Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress

2005 ◽  
Vol 21 (4) ◽  
pp. 986-993 ◽  
Author(s):  
R. Smith ◽  
H. Kaune ◽  
D. Parodi ◽  
M. Madariaga ◽  
R. Rios ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Sperm Dna Damage ◽  
Sperm Dna

Cryopreservation Promotes Sperm DNA Damage Through Oxidative Stress [38N]

2018 ◽  
Vol 131 ◽  
pp. 162S
Author(s):  
Mai Tran ◽  
Heydy Uriondo ◽  
Florencia Nodar ◽  
Cristian Alvarez Sedó
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Sperm Dna Damage ◽  
Sperm Dna

Seminal oxidative stress (OS) is highly correlated with sperm DNA damage in men with idiopathic and male-factor infertility

2002 ◽  
Vol 78 ◽  
pp. S261-S262 ◽  
Author(s):  
Ramadan A Saleh ◽  
Ashok Agarwal ◽  
Essam A Nada ◽  
Mohamed H El-Tonsy ◽  
Donald P Evenson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Male Factor Infertility ◽  
Male Factor ◽  
Sperm Dna Damage ◽  
Sperm Dna ◽  
Highly Correlated

scholarly journals Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis

2009 ◽  
Vol 24 (9) ◽  
pp. 2061-2070 ◽  
Author(s):  
L.K. Thomson ◽  
S.D. Fleming ◽  
R.J. Aitken ◽  
G.N. De Iuliis ◽  
J.-A. Zieschang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Human Sperm ◽  
Sperm Dna Damage ◽  
Sperm Dna

scholarly journals Determine the optimal abstinence for testing of seminal oxidative stress and sperm DNA damage in infertile men

2009 ◽  
Vol 92 (3) ◽  
pp. S210
Author(s):  
R.Z. Mahfouz ◽  
A. Thiyagarajan ◽  
V. Kale ◽  
R.K. Sharma ◽  
E. Sabanegh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Sperm Dna Damage ◽  
Infertile Men ◽  
Sperm Dna

Relationship between male reproductive hormones, sperm DNA damage and markers of oxidative stress in infertility

2007 ◽  
Vol 14 (2) ◽  
pp. 159-165 ◽  
Author(s):  
M Appasamy ◽  
S Muttukrishna ◽  
AR Pizzey ◽  
O Ozturk ◽  
NP Groome ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Reproductive Hormones ◽  
Sperm Dna Damage ◽  
Sperm Dna ◽  
Markers Of Oxidative Stress

scholarly journals Ameliorating potency of Chenopodium album Linn. and vitamin C against mercuric chloride-induced oxidative stress in testes of Sprague Dawley rats

2019 ◽  
Vol 24 (1) ◽  
Author(s):  
Sarwat Jahan ◽  
Tayyaba Azad ◽  
Amina Ayub ◽  
Asad Ullah ◽  
Tayyaba Afsar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Vitamin C ◽  
Mercuric Chloride ◽  
Total Protein ◽  
Chenopodium Album ◽  
Sperm Production ◽  
Sperm Dna Damage ◽  
Sperm Dna ◽  
Daily Sperm Production

Abstract Background Mercury has been documented as an industrial risk that posed a serious danger to human health. Mercury exposure results in oxidative stress that may lead to the pathogenesis of male reproductive dysfunction. The present study investigated the ameliorating potential of Chenopodium album L. and vitamin C against mercuric chloride-induced oxidative deterioration of reproductive functions in adult male rats. Methods Group 1 (control) received saline. Group 2 received Mercury (0.15 mg/kg b.w, i.p) dissolved in distilled water. Groups 3 and 4 were given oral gavage of vitamin C (200 mg/kg b.w) and the ethanolic extract of C. album (200 mg/kg b.w) respectively, along with Mercury (0.15 mg/kg b.w, i.p). Group 5 was treated only with C. album (200 mg/kg b.w). After 30 days of the treatment, the rats were dissected and their testicular tissue and the cauda epididymis were used for biochemical analysis while blood plasma was used for protein determination. Results The applied dose-treatment of Mercury-induced oxidative stress in the testis and cauda epididymis tissues of the rats was apparent by a noteworthy decrease in total protein, CAT, SOD, POD, and GST values while there was increase in ROS and TBARS levels. Furthermore, Mercury decreases daily sperm production and enhanced sperm DNA damage as noticeable by an increase in the head and tail length of comets and decrease in intact DNA. There was no significant effect on the body weight and the weight of the reproductive tissues. Treatment with C. album significantly ameliorated the total protein, ROS, and TBARS content. Similarly, the level of CAT, SOD, POD, and GST was significantly improved and the daily sperm production was significantly increased. Furthermore, C. album administration significantly protected Mercury-induced sperm DNA damage. The results of the extract treatment group were compared with those of vitamin C in detoxifying the oxidative stress and restoring the sperm parameters. Conclusion C. album showed protection against Mercury-induced oxidative stress by ameliorating antioxidant enzyme activity, daily sperm production, and DNA damage in rat testes. This suggests that C. album could be beneficial against toxicity induced by an environmental toxicant.

Sign in / Sign up

Export Citation Format

Share Document