scholarly journals Prevalence of chromosomal abnormalities in 2078 infertile couples referred for assisted reproductive techniques

2005 ◽  
Vol 20 (2) ◽  
pp. 437-442 ◽  
Author(s):  
E. Clementini ◽  
C. Palka ◽  
I. Iezzi ◽  
L. Stuppia ◽  
P. Guanciali-Franchi ◽  
...  
2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Mahdi Sepidarkish ◽  
Reza Omani-Samani ◽  
Mohammad Ali Mansournia ◽  
Mir Saeed Yekaninejad ◽  
Azar Mardi-Mamaghani ◽  
...  

Author(s):  
Subhadra Poornima ◽  
Swarnalatha Daram ◽  
Rama Krishna Devaki ◽  
Hasan Qurratulain

Background: World Health Organization estimates that 60-80 million couple world-wide currently suffer from infertility. Recurrent pregnancy loss (RPL) is also another major concern. Chromosomal rearrangements play a crucial role in primary and secondary infertility and RPL. Underlying genetic abnormalities like chromosomal abnormalities contribute to 5-10% of the reproductive failures. The aim of the study was to evaluate the chromosomal abnormalities in infertility and RPL cases to help obstetrician/fertility experts to carry out risk assessment and provide appropriate assisted reproductive techniques for better management of the problem. Methods: Karyotyping was performed for 414 cases with the history of infertility and RPL over a period of one year. Samples were processed according to procedures of AGT cytogenetic laboratory manual. Results: Chromosomal abnormalities were observed in 15% of cases. Robertsonian translocation, reciprocal translocation, inversion, derivatives, marker chromosomes, mosaics, aneuploidy and polymorphic variants each contributed 2%, 3%, 3%, 13%, 2%, 10%, 6% and 61%, respectively. Conclusion: Evaluation of chromosomal abnormalities in couple is warranted prior to planning pregnancy especially for assisted reproductive management cases. Chro-mosomal analysis can be used as one of the diagnostic tools by OBG/IVF specialists in association with geneticist/genetic counselor for proper reproductive counseling and management.    


2016 ◽  
Vol 14 (12) ◽  
pp. 761-768
Author(s):  
Seyed Alireza Afshani ◽  
Ali Mohammad Abdoli ◽  
Mehrieh Hashempour ◽  
Maryam Baghbeheshti ◽  
Mohammad Zolfaghari ◽  
...  

2013 ◽  
Vol 62 (5) ◽  
Author(s):  
Luis Chiva

delle diverse tecniche di riproduzione assistita nel campo della infertilità umana. In tutti questi anni, sono emerse molte domande riguardo i limiti etici di questi trattamenti, ed i diritti dei pazienti e dei medici di forzare i confini dell’inizio della vita umana , mettendo a rischio la vita di milioni di embrioni umani. In questo ambito ci sono tre principi chiave per poter considerare le terapie mediche per le coppie sterili come un aiuto e non come una sostituzione dell’atto coniugale: in primo luogo, far sì che i rapporti sessuali avvengono come parte del trattamento; in secondo luogo, ottenere sistematicamente gameti della stessa coppia e non da donatori; e, infine, avere cura degli embrioni umani con lo stesso rispetto che merita un essere umano adulto. In base a questi principi, si possono individuare alcune tecniche di procreazione che non effettuano alcuna manipolazione dell’embrione: la stimolazione ovarica e il rapporto sessuale programmato, il trasferimento dei gameti e la coltura intravaginale di gameti. ---------- During the last three decades, we have witnessed the overwhelming growth of different assisted reproductive techniques within the field of human infertility. In all these years, many questions have emerged regarding the ethical limits of these treatments, and the rights of patients and doctors to push the boundaries of the commencement of human life, putting the life of millions of human embryos at risk. In this area there are three key principles to consider the medical therapy for infertile couples as an assistance and not as a substitution of the conjugal act: first, to encourage that sexual relations take place as part of the treatment; second, to systematically obtain the gametes from the couple themselves and not from donors, and finally, to take care of human embryos with the same respect as a human adult deserves. In accordance to these principles, there are some reproductive techniques without embryo manipulation: ovarian stimulation and programmed intercourse, gamete transfer and intravaginal culture of gametes (INVO).


2020 ◽  
Author(s):  
Ellieh khoei ◽  
Seyyed Abolfazl Afjeh ◽  
saleheh tajalli ◽  
Minoo Fallahi

Abstract Background: Outcomes of neonates of infertile couples that are golden babies and care of them is an issue of importance. But it is not yet clear if the prognosis is different between them and neonates from fertile couples. The purpose of this study was to determine the outcome of neonates conceived by assisted reproductive techniques.Methods: In this cohort study, a total of 165 newborn who were conceived by ART and 165 naturally concieved newborns were enrolled. The study was prospective from April 2016 to October 2017. All newborns were examined by neonatologist after birth and their outcome were followed up to one year. The outcomes were compared with neonates from fertile couple using appropriate statistical tests.Results: The preterm neonates (60% vs. 38%) were higher in ART cases (P<0.001). The mean gravid and parity were lower in ART group (P<0.001) and the nulliparity was higher in them. Multiple pregnancies were higher in ART cases (45% vs. 10%; P<0. 001). C/S rate was higher (91% vs 67%) in ART cases (P<0.001). Pre-eclampsia rate was higher in ART cases (16 % vs. 6%; P=0.004). Female sex was higher in ART group (P=0.035). Birth weight was significantly lower in ART group (P=0.002) and the Apgar was also lower (P=0.002; P=0.012). IUGR was significantly higher (17% vs. 7%) in ART group (P=0.006). NEC and RDS were more common in ART group (P<0.001). Hospital stay was longer in ART group (P<0.001). Re-admission, and weight less than 5th percentile were more common after one year in ART group (P=0.021).Conclusion: According to the obtained results, pregnancy after ART has more side effects before and after birth and also in infancy; not only because of multigestation but also due to manipulations in ART.


2021 ◽  
Vol 8 ◽  
Author(s):  
Zichun Wang ◽  
Wanpeng Liu ◽  
Mingming Zhang ◽  
Minglei Wang ◽  
Huaying Wu ◽  
...  

Background: Hepatitis B virus (HBV) infection is one of the health problems and has adverse effects on public health. However, the consequences of male HBV carriers for assisted reproductive techniques (ART) remain unclear.Objective: To examine whether men with HBV would impact sperm quality and the intrauterine insemination (IUI)/ in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) outcomes.Methods: We retrospectively analyzed data from 681 infertile couples for IUI/IVF/ICSI fresh cycle outcomes. Case group was 176 infertile couples with male HBV infection undergoing embryo transfer in our center (99 for IVF and 77 for ICSI) and 51 infertile couples for IUI. Negative control was 454 non-infected infertility couples, matched for female age, BMI and infertility duration (102 for IUI and 198 for IVF and 154 for ICSI).Results: Sperm viability among infertile men with HBV infection was significantly lower than control group (74.1 ± 13.7 vs. 77.0 ± 12.8, P &lt; 0.01). Sperm motility was significantly decreased in HBV positive men in comparison to the control group (32.5 ± 14.6 vs. 35.5 ± 12.9, P &lt; 0.05). In IVF/ICSI cycles, two groups had similar results in two pronuclear (2PN) fertilization rate, implantation rate, clinical pregnant rate and abortion rate (P &gt; 0.05). There was also no difference in the clinical pregnant rate and abortion rate in IUI cycles (P &gt; 0.05).Conclusion: Men with HBV infection will affect their sperm quality, but not affect the outcomes of ART.


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