scholarly journals Novel universal approach for preimplantation genetic diagnosis of  -thalassaemia in combination with HLA matching of embryos

2004 ◽  
Vol 19 (3) ◽  
pp. 700-708 ◽  
Author(s):  
H. Van de Velde
Keyword(s):  
Preimplantation Genetic Diagnosis ◽  
Genetic Diagnosis ◽  
Hla Matching ◽  
Universal Approach

scholarly journals P39 Preimplantation genetic diagnosis (PGD) for HLA matching in leukemia

2012 ◽  
Vol 24 ◽  
pp. S61
Author(s):  
Y. Yaron ◽  
V. Gold ◽  
S. Peleg ◽  
T. Frumkin ◽  
A. Benny ◽  
...  
Keyword(s):  
Preimplantation Genetic Diagnosis ◽  
Genetic Diagnosis ◽  
Hla Matching

scholarly journals Preimplantation genetic diagnosis with HLA matching

2004 ◽  
Vol 9 (2) ◽  
pp. 210-221 ◽  
Author(s):  
Svetlana Rechitsky ◽  
Anver Kuliev ◽  
Illan Tur-Kaspa ◽  
Randy Morris ◽  
Yury Verlinsky
Keyword(s):  
Preimplantation Genetic Diagnosis ◽  
Genetic Diagnosis ◽  
Hla Matching

Experience on Preimplantation Genetic Diagnosis Combined With HLA Matching

2005 ◽  
Vol 84 ◽  
pp. S99
Author(s):  
F. Fiorentino ◽  
S. Kahraman ◽  
H. Karadayi ◽  
A. Biricik ◽  
S. Sertyel ◽  
...  
Keyword(s):  
Preimplantation Genetic Diagnosis ◽  
Genetic Diagnosis ◽  
Hla Matching

Preimplantation Genetic Diagnosis for single gene disorders combined with HLA matching

2004 ◽  
Vol 82 ◽  
pp. S247-S248
Author(s):  
S. Kahraman ◽  
G. Karlikaya ◽  
H. Karadayi ◽  
B. Umay ◽  
Y. Saglam ◽  
...  
Keyword(s):  
Preimplantation Genetic Diagnosis ◽  
Single Gene ◽  
Genetic Diagnosis ◽  
Hla Matching ◽  
Single Gene Disorders

scholarly journals Experience of Preimplantation Genetic Diagnosis with HLA Matching at the University Hospital Virgen del Rocío in Spain: Technical and Clinical Overview

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Raquel María Fernández ◽  
Ana Peciña ◽  
Maria Dolores Lozano-Arana ◽  
Beatriz Sánchez ◽  
Jordi Guardiola ◽  
...  
Keyword(s):  
Preimplantation Genetic Diagnosis ◽  
Genetic Diseases ◽  
Genetic Diagnosis ◽  
Hla Typing ◽  
University Hospital ◽  
Haematopoietic Stem Cell ◽  
Tissue Type ◽  
Hla Matching ◽  
The University ◽  
Clinical Overview

Preimplantation genetic diagnosis (PGD) of genetic diseases, combined with HLA matching (PGD-HLA), is an option for couples at risk of transmitting a genetic disease to select unaffected embryos of an HLA tissue type compatible with that of an existing affected child. Here we present the results of our PGD-HLA program at the Department of Genetics, Reproduction and Fetal Medicine of the University Hospital Virgen del Rocío in Seville. Seven couples have participated in our program because of different indications. Overall, 26 cycles were performed, providing a total of 202 embryos. A conclusive molecular diagnosis and HLA-typing could be assured in 96% of the embryos. The percentage of transfers per cycle was 26.9% and the birth rate per cycle was 7.7% per transfer. Our PGD-HLA program resulted in the birth of 2 healthy babies, HLA-identical to their affected siblings, with successful subsequent haematopoietic stem cell (HSC) transplantations. Both HSC-transplanted children are currently doing well 48 and 21 months following transplantation, respectively. All the procedures, including HSCs umbilical cord transplantation, were performed in our hospital.

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