scholarly journals Expression of nitric oxide synthase and effect of substrate manipulation of the nitric oxide pathway in mouse ovarian follicles

2004 ◽  
Vol 19 (1) ◽  
pp. 30-40 ◽  
Author(s):  
L. M. Mitchell
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Ovarian Follicles ◽  
Oxide Synthase ◽  
Nitric Oxide Pathway

ALTERED l-ARGININE/NITRIC OXIDE SYNTHASE/NITRIC OXIDE PATHWAY IN THE VASCULAR ADVENTITIA OF RATS WITH SEPSIS

2006 ◽  
Vol 33 (12) ◽  
pp. 1202-1208 ◽  
Author(s):  
Yue Xia Jia ◽  
Chun Shui Pan ◽  
Jing Hui Yang ◽  
Xiu Hua Liu ◽  
Wen Jun Yuan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Nitric Oxide Pathway

Apelin activates l-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas

Peptides ◽  
2007 ◽  
Vol 28 (10) ◽  
pp. 2023-2029 ◽  
Author(s):  
Yue Xia Jia ◽  
Zheng Fei Lu ◽  
Jing Zhang ◽  
Chun Shui Pan ◽  
Jing Hui Yang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Nitric Oxide Pathway

Intermedin1-53 activates l-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas

2006 ◽  
Vol 341 (2) ◽  
pp. 567-572 ◽  
Author(s):  
Jing-Hui Yang ◽  
Chun-Shui Pan ◽  
Yue-Xia Jia ◽  
Jing Zhang ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Nitric Oxide Pathway

Effect of homocysteine on the l -arginine/nitric oxide synthase/nitric oxide pathway in human platelets

2002 ◽  
Vol 16 (2) ◽  
pp. 46-50 ◽  
Author(s):  
Juxiang Li ◽  
Yonggang Zhang ◽  
Xinghai Yao ◽  
Baowei Zhang ◽  
Junbao Du ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Human Platelets ◽  
Oxide Synthase ◽  
Nitric Oxide Pathway

scholarly journals The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches

2021 ◽  
Vol 22 (9) ◽  
pp. 4540
Author(s):  
Han-Yan Zhu ◽  
Fen-Fang Hong ◽  
Shu-Long Yang
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Vascular Dementia ◽  
Cognitive Abilities ◽  
No Production ◽  
Therapeutic Approaches ◽  
Oxide Synthase ◽  
The Brain ◽  
Nitric Oxide Pathway ◽  
Inducible Nos

Vascular dementia (VaD) is the second most common form of dementia worldwide. It is caused by cerebrovascular disease, and patients often show severe impairments of advanced cognitive abilities. Nitric oxide synthase (NOS) and nitric oxide (NO) play vital roles in the pathogenesis of VaD. The functions of NO are determined by its concentration and bioavailability, which are regulated by NOS activity. The activities of different NOS subtypes in the brain are partitioned. Pathologically, endothelial NOS is inactivated, which causes insufficient NO production and aggravates oxidative stress before inducing cerebrovascular endothelial dysfunction, while neuronal NOS is overactive and can produce excessive NO to cause neurotoxicity. Meanwhile, inflammation stimulates the massive expression of inducible NOS, which also produces excessive NO and then induces neuroinflammation. The vicious circle of these kinds of damage having impacts on each other finally leads to VaD. This review summarizes the roles of the NOS/NO pathway in the pathology of VaD and also proposes some potential therapeutic methods that target this pathway in the hope of inspiring novel ideas for VaD therapeutic approaches.

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