scholarly journals In-utero androgen exposure and 2nd to 4th digit length ratio--comparisons between healthy controls and females with classical congenital adrenal hyperplasia

2003 ◽  
Vol 18 (5) ◽  
pp. 976-979 ◽  
Author(s):  
J.J. Buck
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
In Utero ◽  
Length Ratio ◽  
Healthy Controls ◽  
Adrenal Hyperplasia ◽  
Androgen Exposure ◽  
Digit Length

Prenatal Therapy in Congenital Adrenal Hyperplasia Attempted Prevention of Abnormal External Genital Masculinization by Pharmacologic Suppression of the Fetal Adrenal Gland in Utero

1985 ◽  
Vol 458 (1 Congenital Ad) ◽  
pp. 156-164 ◽  
Author(s):  
GEORGE P. CHROUSOS ◽  
MARK I. EVANS ◽  
D. LYNN LORIAUX ◽  
JAMES McCLUSKEY ◽  
JOHN C. FLETCHER ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Congenital Adrenal Hyperplasia ◽  
In Utero ◽  
Adrenal Hyperplasia

Sonographic Appearance of Congenital Adrenal Hyperplasia In Utero

2002 ◽  
Vol 21 (1) ◽  
pp. 97-100 ◽  
Author(s):  
Evelyne Diane Chambrier ◽  
Claudine Heinrichs ◽  
Fred E. Avni
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
In Utero ◽  
Adrenal Hyperplasia ◽  
Sonographic Appearance

scholarly journals Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia

2019 ◽  
Vol 181 (5) ◽  
pp. 481-488 ◽  
Author(s):  
Lee S Nguyen ◽  
Nathalie Rouas-Freiss ◽  
Christian Funck-Brentano ◽  
Monique Leban ◽  
Edgardo D Carosella ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Critical Role ◽  
Renin Angiotensin System ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Adrenal Hyperplasia ◽  
Cross Sectional ◽  
Adequate Model ◽  
Soluble Hla

Background HLA-G is an immune checkpoint molecule, naturally expressed during pregnancy, playing a critical role in the tolerance of the fetal semi-allograft from the maternal immune system. While HLA-G expression levels are associated with progesterone, the influence of other hormones is still unclear. Congenital adrenal hyperplasia (CAH) represents an adequate model to study the hormonal influence on biomarkers as it leads to impaired cortisol biosynthesis and increased progesterone and androgens production due to 21-hydroxylase enzyme deficiency. Methods In a cross-sectional study of CAH patients matched on sex and age with healthy control, the association between circulating levels of soluble HLA-G and hormones was assessed by use of non-parametric analyses tests. Multivariable linear regressions were performed on normalized data. Results Overall, 83 CAH patients and 69 healthy controls were included. Among CAH patients, all were under glucocorticoid and 52 (62.6%) were under mineralocorticoid supplementation. Compared to controls, CAH patients had increased HLA-G levels (15 vs 8 ng/mL, P = 0.02). In controls, HLA-G level was independently associated with progesterone and estradiol (β = 0.44 (0.35–1.27) and −0.44 (−0.94, −0.26) respectively, both P values = 0.001). In CAH patients, HLA-G level was independently associated with mineralocorticoid supplementation dosage (β = 0.25 (0.04–0.41), P = 0.001) and estradiol (β = −0.22 (−0.57, −0.02), P < 0.001). Conclusion CAH patients had higher HLA-G levels than healthy controls. HLA-G level was positively associated with progesterone and corticosteroid supplementation, and negatively with estradiol. The association between mineralocorticoid, renin and HLA-G levels may suggest a role of the renin-angiotensin system in the expression of soluble HLA-G.

scholarly journals Personality and congenital adrenal hyperplasia: Possible effects of prenatal androgen exposure

2009 ◽  
Vol 55 (2) ◽  
pp. 285-291 ◽  
Author(s):  
Greta A. Mathews ◽  
Briony A. Fane ◽  
Gerard S. Conway ◽  
Charles G.D. Brook ◽  
Melissa Hines
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adrenal Hyperplasia ◽  
Androgen Exposure ◽  
Prenatal Androgen Exposure ◽  
Prenatal Androgen

scholarly journals No Evidence for a Difference in 2D:4D Ratio between Youth with Elevated Prenatal Androgen Exposure due to Congenital Adrenal Hyperplasia and Controls

2020 ◽  
Author(s):  
Gideon Nave ◽  
Christina M. Koppin ◽  
Dylan Manfredi ◽  
Gareth Richards ◽  
Steven J. Watson ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Large Body ◽  
Adrenal Hyperplasia ◽  
Hydroxylase Deficiency ◽  
Left Hand ◽  
Androgen Exposure ◽  
Wide Range ◽  
Prenatal Androgen Exposure ◽  
21 Hydroxylase Deficiency ◽  
Prenatal Androgen

AbstractThe second-to-fourth digit ratio (2D:4D) has been associated with sexual dimorphism, with a lower 2D:4D in males. A large body of research has relied on the 2D:4D as a proxy for prenatal androgen exposure, and includes reports of relationships between 2D:4D and a wide range of human traits. Here, we examine the validity of the 2D:4D proxy by studying the association between 2D:4D and classical Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency, a condition characterized by excessive prenatal exposure to androgens during most of the gestational period. To this end, we retrospectively examine 513 serial radiographs of the left hand obtained clinically in 90 youth with classical CAH (45 female) and 70 control youth (31 female). Replicating previous reports, we observe associations of the 2D:4D with sex (lower 2D:4D in males) and age (increase of 2D:4D through development). However, we find no evidence for differences in 2D:4D between CAH and controls (full sample: □ = -0.001 (−0.008, 0.006)]; females: □ = -0.004 [-0.015, 0.007]; males: □ = 0.001, [-0.008, 0.011]). Although our findings do not rule out a small association between the 2D:4D and CAH, they cast doubt on the usefulness of the 2D:4D as a biomarker for prenatal androgen exposure in behavioral research.

Sign in / Sign up

Export Citation Format

Share Document