A simple, low cost and non-invasive method for screening Y-chromosome microdeletions in infertile men

2003 ◽  
Vol 18 (2) ◽  
pp. 257-261 ◽  
Author(s):  
I.E. Aknin-Seifer
Keyword(s):  
Y Chromosome ◽  
Low Cost ◽  
Non Invasive ◽  
Infertile Men ◽  
Y Chromosome Microdeletions ◽  
Invasive Method

Detection Y Chromosome Microdeletions Among Iraq Population in Infertile Patients with Azoospermia and Severe Oligospermia

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Samah A Hammood ◽  
Alaauldeen S M AL-Sallami ◽  
Saleh M Al-Khafaji
Keyword(s):  
Y Chromosome ◽  
Karyotype Analysis ◽  
Semen Analysis ◽  
Obstructive Azoospermia ◽  
Severe Oligozoospermia ◽  
Infertile Men ◽  
Y Chromosome Microdeletions ◽  
Detailed Evaluation ◽  
Health Organization ◽  
Infertile Patients

Objective: To detection of microdeletions of Y chromosome and study the frequency of microdeletions in infertile men with non-obstructive azoospermia or severe oligozoospermia(Middle Euphrates center)in Iraq population. Material and methods: 153 males were included in the study, the casesweredivided into groups according to the infertility etiology and semen analysis according to Word health organization, the frequencies and the characteristicsof Y chromosome microdeletions were investigated in groups. Multiplex PCR was applied to detect the microdeletions. Results:Y chromosome microdeletion was detected in 42 (40.7%) of 153 cases ,Microdeletions in azoospermia showed more frequently detected 28 (52.8%), followed by severe oligospermia 14 (28 %),Microdeletions in the AZFc region were the most common 12 (22.64%), followed by AZFb 11(20.75%) and AZFa 5(9.43%) in azoospermia compared to severe oligospermisAZFc 6 (12%) AZFb 4 (8 %) and AZFa 4 (8%). Conclusion: Y chromosome microdeletions were detected quite frequently in certain infertility subgroups. Therefore, detailed evaluation of an infertile man by physical examination, semen analysis, hormonal evaluationsand when required, karyotype analysis may predict the patients for whom Y chromosome microdeletionanalysis is necessary and also prevent cost increases. Recommendation: This study emphasizes that analysis of microdeletions should be carried out for all patients with idiopathic azoospermia and severe oligospermia who are candidates for intracytoplasmic sperm injection

The incidence of Y-chromosome microdeletions in Pakistani infertile men

2011 ◽  
Vol 22 ◽  
pp. S42
Author(s):  
Nosheen Mujtaba ◽  
Mamoona Naz ◽  
Saima Perveen ◽  
Mamoona Yasmin ◽  
Fida Haider ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Infertile Men ◽  
Y Chromosome Microdeletions

scholarly journals In-Vehicle Alcohol Detection Using Low-Cost Sensors and Genetic Algorithms to Aid in the Drinking and Driving Detection

Sensors ◽  
2021 ◽  
Vol 21 (22) ◽  
pp. 7752
Author(s):  
Jose M. Celaya-Padilla ◽  
Jonathan S. Romero-González ◽  
Carlos E. Galvan-Tejada ◽  
Jorge I. Galvan-Tejada ◽  
Huizilopoztli Luna-García ◽  
...  
Keyword(s):  
Motor Vehicle ◽  
Low Cost ◽  
Child Death ◽  
Classification Model ◽  
Selection Strategy ◽  
Drinking And Driving ◽  
Forward Selection ◽  
Vehicle Accidents ◽  
Non Invasive ◽  
Invasive Method

Worldwide, motor vehicle accidents are one of the leading causes of death, with alcohol-related accidents playing a significant role, particularly in child death. Aiming to aid in the prevention of this type of accidents, a novel non-invasive method capable of detecting the presence of alcohol inside a motor vehicle is presented. The proposed methodology uses a series of low-cost alcohol MQ3 sensors located inside the vehicle, whose signals are stored, standardized, time-adjusted, and transformed into 5 s window samples. Statistical features are extracted from each sample and a feature selection strategy is carried out using a genetic algorithm, and a forward selection and backwards elimination methodology. The four features derived from this process were used to construct an SVM classification model that detects presence of alcohol. The experiments yielded 7200 samples, 80% of which were used to train the model. The rest were used to evaluate the performance of the model, which obtained an area under the ROC curve of 0.98 and a sensitivity of 0.979. These results suggest that the proposed methodology can be used to detect the presence of alcohol and enforce prevention actions.

scholarly journals Obstetric and perinatal outcomes of intracytoplasmic sperm injection for infertile men with Y chromosome microdeletions

Medicine ◽  
2019 ◽  
Vol 98 (41) ◽  
pp. e17407
Author(s):  
Qi Xi ◽  
Zhihong Zhang ◽  
Ruixue Wang ◽  
Linlin Li ◽  
Leilei Li ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Intracytoplasmic Sperm Injection ◽  
Perinatal Outcomes ◽  
Infertile Men ◽  
Y Chromosome Microdeletions

scholarly journals Challenging the guidelines: Proposal of a new sperm concentration cut-off for Y chromosome microdeletions testing in primary infertile men

2020 ◽  
Vol 19 ◽  
pp. e541-e542
Author(s):  
W. Cazzaniga ◽  
P. Capogrosso ◽  
L. Boeri ◽  
E. Ventimiglia ◽  
E. Pozzi ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Sperm Concentration ◽  
Infertile Men ◽  
Y Chromosome Microdeletions

Y Chromosome Microdeletions and Partial AZFc Deletions in Infertile Men from South India

2016 ◽  
Vol 13 (12) ◽  
pp. 1-10 ◽  
Author(s):  
Jaganathan Suganya ◽  
Smita Kujur ◽  
Kamala Selvaraj ◽  
Muthiah Suruli ◽  
Geetha Haripriya ◽  
...  
Keyword(s):  
Y Chromosome ◽  
South India ◽  
Infertile Men ◽  
Y Chromosome Microdeletions

scholarly journals Aberrations in Pseudoautosomal Regions (PARs) Found in Infertile Men with Y-Chromosome Microdeletions

2011 ◽  
Vol 96 (4) ◽  
pp. E674-E679 ◽  
Author(s):  
Carolina J. Jorgez ◽  
John W. Weedin ◽  
Aysegul Sahin ◽  
Mounia Tannour-Louet ◽  
Shuo Han ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Quantitative Pcr ◽  
Comparative Genomic Hybridization ◽  
Array Comparative Genomic Hybridization ◽  
Structural Defects ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Infertile Men ◽  
Y Chromosome Microdeletions ◽  
Pseudoautosomal Regions

Abstract Context: The pseudoautosomal regions (PARs) of the Y-chromosome undergo meiotic recombination with the X-chromosome. PAR mutations are associated with infertility and mental and stature disorders. Objective: The aim of the study was to determine whether men with Y-chromosome microdeletions have structural defects in PARs. Design and Participants: Eighty-seven infertile men with Y-chromosome microdeletions and 35 controls were evaluated for chromosomal rearrangements using commercial or custom (X- and Y-chromosome) array comparative genomic hybridization or by quantitative PCR of selected PAR genes. Multisoftware-defined chromosomal gains or losses were validated by quantitative PCR and FISH. Results: Array comparative genomic hybridization confirmed the AZF deletions identified by multiplex PCR. All men with Y-chromosome microdeletions and an abnormal karyotype displayed PAR abnormalities, as did 10% of men with Y-chromosome microdeletions and a normal karyotype. None of the control subjects or infertile men without Y-chromosome microdeletions had PAR duplications or deletions. SHOX aberrations occurred in 14 men (nine gains and five losses); four were short in stature (<10th percentile), and one was tall (>95th percentile). In contrast, the height of 23 men with Y-chromosome microdeletions and normal PARs was average at 176.8 cm (50th percentile). Conclusions: Y-chromosome microdeletions can include PAR defects causing genomic disorders such as SHOX, which may be transmitted to offspring. Previously unrecognized PAR gains and losses in men with Y-chromosome microdeletions may have consequences for offspring.

scholarly journals Development a low-cost electrical impedance tomography system for non-invasively detecting abnormal in breast tissue - Phantom study-

10.29007/x6vj ◽  
2022 ◽  
Author(s):  
Minh Quan Cao Dinh ◽  
Quoc Tuan Nguyen Diep ◽  
Hoang Nhut Huynh ◽  
Ngoc An Dang Nguyen ◽  
Anh Tu Tran ◽  
...  
Keyword(s):  
Electrical Impedance Tomography ◽  
Electrical Impedance ◽  
Low Cost ◽  
Impedance Tomography ◽  
Non Invasive ◽  
Tomography System ◽  
Tissue Phantom ◽  
Cost System ◽  
Invasive Method ◽  
Breast Tissues

Electrical Impedance Tomography (EIT) is known as non-invasive method to detect and classify the abnormal breast tissues. Reimaging conductivity distribution within an area of the subject reveal abnormal tissues inside that area. In this work, we have created a very low-cost system with a simple 16-electrode phantom for doing research purposes. The EIT data were measured and reconstructed with EIDORS software.

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