scholarly journals PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death

2014 ◽  
Vol 24 (4) ◽  
pp. 1127-1141 ◽  
Author(s):  
Hyo-Kyoung Choi ◽  
Youngsok Choi ◽  
HeeBum Kang ◽  
Eun-jin Lim ◽  
Soo-Yeon Park ◽  
...  
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Dopaminergic Neuronal Cell

scholarly journals 1-O-Hexyl-2,3,5-Trimethylhydroquinone Ameliorates l-DOPA-Induced Cytotoxicity in PC12 Cells

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 867 ◽  
Author(s):  
Hyun Park ◽  
Jong Kang ◽  
Myung Lee
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Pc12 Cells ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Mitogen Activated Protein Kinase ◽  
Protective Effects ◽  
Extracellular Signal ◽  
Dopaminergic Neuronal Cell ◽  
Mitogen Activated Protein

1-O-Hexyl-2,3,5-trimethylhydroquinone (HTHQ) has previously been found to have effective anti-oxidant and anti-lipid-peroxidative activity. We aimed to elucidate whether HTHQ can prevent dopaminergic neuronal cell death by investigating the effect on l-DOPA-induced cytotoxicity in PC12 cells. HTHQ protected from both l-DOPA-induced cell death and superoxide dismutase activity reduction. When assessing the effect of HTHQ on oxidative stress-related signaling pathways, HTHQ inhibited l-DOPA-induced phosphorylation of sustained extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). HTHQ also normalized l-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression, promoting cell survival. Taken together, HTHQ exhibits protective effects against l-DOPA-induced cell death through modulation of the ERK1/2-p38MAPK-JNK1/2-Bad-Bax signaling pathway in PC12 cells. These results suggest that HTHQ may show ameliorative effects against oxidative stress-induced dopaminergic neuronal cell death, although further studies in animal models of Parkinson’s disease are required to confirm this.

scholarly journals Berberine protects 6-hydroxydopamine-induced human dopaminergic neuronal cell death through the induction of heme oxygenase-1

2013 ◽  
Vol 35 (2) ◽  
pp. 151-157 ◽  
Author(s):  
Jinbum Bae ◽  
Danbi Lee ◽  
Yun Kyu Kim ◽  
Minchan Gil ◽  
Joo-Yong Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Heme Oxygenase ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Heme Oxygenase 1 ◽  
Dopaminergic Neuronal Cell ◽  
6 Hydroxydopamine

Microarray expression profiling in 6-hydroxydopamine-induced dopaminergic neuronal cell death

2011 ◽  
Vol 118 (11) ◽  
pp. 1585-1598 ◽  
Author(s):  
Bokyung Park ◽  
Chang-Ki Oh ◽  
Won-Seok Choi ◽  
In Kwon Chung ◽  
Moussa B. H. Youdim ◽  
...  
Keyword(s):  
Cell Death ◽  
Expression Profiling ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Dopaminergic Neuronal Cell ◽  
Microarray Expression Profiling ◽  
6 Hydroxydopamine ◽  
Microarray Expression
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