scholarly journals An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution

2014 ◽  
Vol 23 (25) ◽  
pp. 6863-6877 ◽  
Author(s):  
Li Zhu ◽  
Meng Xu ◽  
Mengxue Yang ◽  
Yanlian Yang ◽  
Yang Li ◽  
...  
Keyword(s):  
Neurotoxic Peptide

Molecular Docking and 3D Qsar Studies of C000000956 as a Potent Inhibitor of Bace-1

Drug Research ◽  
2019 ◽  
Vol 69 (08) ◽  
pp. 451-457 ◽  
Author(s):  
Ogunleye Adewale Joseph ◽  
Kikiowo Babatomiwa ◽  
Adelakun Niyi ◽  
Omotuyi Olaposi ◽  
Inyang Olumide
Keyword(s):  
Molecular Docking ◽  
Small Molecule ◽  
3D Qsar ◽  
Small Molecule Inhibitor ◽  
Computational Pipeline ◽  
Qsar Studies ◽  
Neurotoxic Peptide ◽  
Molecule Inhibitor ◽  
Ad Therapy ◽  
Bace 1

Abstract Background BACE-1 is an aspartate protease that is responsible for the proteolysis of amyloid precursor proteins (APP) into beta-amyloid (Aβ), a neurotoxic peptide in patients with Alzheimer’s disease (AD). As such, BACE-1 is a prime pharmacological target in the control of Aβ in the brain and its inhibition will be a sound approach in AD therapy. Methods The computational pipeline which comprised molecular docking (MD), Quantitative Structure Activity Relationship (QSAR) modelling and Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) studies enabled the prediction of molecular interaction and relative inhibitory potentials of the hit compound. Results and Discussion The current study reports a naturally sourced small molecule inhibitor of BACE1 (C000000956) which was obtained through a computational pipeline. Also, pharmacological constraints such as pH dependent activity of the enzyme and blood brain barrier permeation which have been associated with the efficacy of previous BACE-1 inhibitors were well catered for. Our results suggest that orally delivered C000000956 is a potential small molecule inhibitor of BACE-1 which may find usefulness in AD-therapy.

A lysine rich C-terminal tail is directly involved in the toxicity of CSTX-1, a neurotoxic peptide from the venom of the spiderCupiennius salei

2000 ◽  
Vol 44 (3) ◽  
pp. 101-111 ◽  
Author(s):  
Lucia Kuhn-Nentwig ◽  
Johann Schaller ◽  
Urs K�mpfer ◽  
Hans Imboden ◽  
Heinz Malli ◽  
...  
Keyword(s):  
Neurotoxic Peptide

scholarly journals Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD Mice

2011 ◽  
Vol 2 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Merina Varghese ◽  
Wei Zhao ◽  
Jun Wang ◽  
Alice Cheng ◽  
Xianjuan Qian ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Mitochondrial Respiration ◽  
Beta Amyloid ◽  
Mitochondrial Fraction ◽  
Mitochondrial Bioenergetics ◽  
Synaptic Terminals ◽  
Neurotoxic Peptide ◽  
Age Related ◽  
The Brain ◽  
Tg2576 Mice

AbstractAlzheimer’s disease (AD) is an age-related dementia, with the pathological hallmarks of neuritic plaques and neurofibrillary tangles, brain atrophy and loss of synaptic terminals. Dysfunctional mitochondrial bioenergetics is implicated as a contributing factor to the cognitive decline observed in AD. We hypothesized that, in the presence of the AD neurotoxic peptide beta-amyloid, mitochondrial respiration is impaired early in synaptic terminals, which are vital to cognitive performance, preferentially in cognitive centers of the brain. We compared oxygen consumption in synaptosomal and perikaryal mitochondria prepared from the cerebral cortex and cerebellum of wild type (WT) and AD transgenic Tg2576 mice. Compared to WT mice, Tg2576 mice showed decreased mitochondrial respiration in the cerebral cortex specifically in synaptosomal fraction, while the perikaryal mitochondria were unaffected. Neither mitochondrial fraction was affected in the cerebellum of Tg2576 mice as compared to WT. The occurrence of a bioenergetic defect in synaptic terminals of mice overexpressing mutant beta-amyloid, in particular in an area of the brain important to cognition, points to an early role of mitochondrial defects in the onset of cognitive deficits in AD.

Purification, Characterization, and Chemical Modification of Neurotoxic Peptide fromDaboia russeliiSnake Venom of India

2013 ◽  
Vol 27 (6) ◽  
pp. 295-304 ◽  
Author(s):  
Madhukumar Venkatesh ◽  
Nijaguna Prasad ◽  
Tej Sing ◽  
Veerabasappa Gowda
Keyword(s):  
Chemical Modification ◽  
Neurotoxic Peptide

scholarly journals An efficient strategy for expression and purification of spider neurotoxic peptide YC1 in E. coli

2017 ◽  
Vol 3 (1) ◽  
pp. 1317898
Author(s):  
Hui Wu ◽  
Wen-Ying Li ◽  
Lei Wu ◽  
Ling-Yun Zhu ◽  
Er Meng ◽  
...  
Keyword(s):  
Expression And Purification ◽  
E Coli ◽  
Efficient Strategy ◽  
Neurotoxic Peptide

Calitoxin, a neurotoxic peptide from the sea anemone Calliactis parasitica: amino-acid sequence and electrophysiological properties

Biochemistry ◽  
1989 ◽  
Vol 28 (6) ◽  
pp. 2484-2489 ◽  
Author(s):  
Lucio Cariello ◽  
A. De Santis ◽  
F. Fiore ◽  
R. Piccoli ◽  
A. Spagnuolo ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Sea Anemone ◽  
Electrophysiological Properties ◽  
Neurotoxic Peptide ◽  
Calliactis Parasitica

scholarly journals Synthesis of Apamin, a Neurotoxic Peptide from Bee Venom

1975 ◽  
Vol 56 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Jurphaas RIETSCHOTEN ◽  
Claude GRANIER ◽  
Herve ROCHAT ◽  
Francois MIRANDA ◽  
Serge LISSITZKY
Keyword(s):  
Bee Venom ◽  
Neurotoxic Peptide

Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide

2013 ◽  
Vol 34 (12) ◽  
pp. 2805-2814 ◽  
Author(s):  
Christian Peters ◽  
Eduardo J. Fernandez-Perez ◽  
Carlos F. Burgos ◽  
María P. Espinoza ◽  
Carolina Castillo ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Neurotoxic Peptide
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