scholarly journals Whole-genome detection of disease-associated deletions or excess homozygosity in a case-control study of rheumatoid arthritis

2012 ◽  
Vol 22 (6) ◽  
pp. 1249-1261 ◽  
Author(s):  
C.-C. Wu ◽  
S. Shete ◽  
E.-J. Jo ◽  
Y. Xu ◽  
E. Y. Lu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Control Study ◽  
Case Control ◽  
Whole Genome ◽  
Excess Homozygosity ◽  
Control Study

Serum Complement C3 and Type 2 Diabetes in Rheumatoid Arthritis: A Case-Control Study

2018 ◽  
Vol 13 (3) ◽  
pp. 215-221 ◽  
Author(s):  
Francesco Ursini ◽  
Salvatore D`Angelo ◽  
Emilio Russo ◽  
Giorgio Ammerata ◽  
Ludovico Abenavoli ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Type 2 Diabetes ◽  
Case Control Study ◽  
Case Control ◽  
Complement C3 ◽  
Serum Complement ◽  
Control Study

scholarly journals SAT0077 CARDIOVASCULAR RISK ASSESSMENT WITH CAROTID ULTRASONOGRAPHY IN ADDITION TO THE TRADITIONAL CARDIOVASCULAR RISK FACTORS IN RHEUMATOID ARTHRITIS PATIENTS: A CASE CONTROL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 973-973
Author(s):  
R. Gonzalez Mazario ◽  
J. J. Fragio-Gil ◽  
P. Martinez Calabuig ◽  
E. Grau García ◽  
M. De la Rubia Navarro ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Disease Duration ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Carotid Ultrasonography ◽  
Control Study

Background:Cardiovascular disease (CV) is the most frequent cause of death in rheumatoid arthritis (RA) patients. It is well known that RA acts as an independent cardiovascular risk factor.Objectives:To assess the CV risk in RA patients using carotid ultrasonography (US) additionally to the traditional CV risk factors.Methods:A prospective transversal case control study was performed, including adult RA patients who fulfilled ACR/EULAR 2010 criteria and healthy controls matched according to CV risk factors. Population over 75 years old, patients with established CV disease and/or chronic kidney failure (from III stage) were excluded. The US evaluator was blinded to the case/control condition and evaluated the presence of plaques and the intima-media thickness. Statistical analysis was performed with R (3.6.1 version) and included a multivariate variance analysis (MANOVA) and a negative binomial regression adjusted by confounding factors (age, sex and CV risk factors).Results:A total of 200 cases and 111 healthy controls were included in the study. Demographical, clinical and US data are exposed in table 1. Not any difference was detected in terms of CV risk factors between the cases and controls. In both groups a relationship between age, BMI and high blood pressure was detected (p<0.001).Table 1.Table 2.RA basal characteristicsDisease duration (years)16,98 (11,38)Erosions (X-Ray of hands/feet)163 (81,5%)Seropositive (RF/anti-CCP)146 (73%)Extra-articular symptoms44 (22%)Intersticial difusse lung disease10 (5%)Rheumatoid nodules14 (7%)Prednisone use103 (51,5%)Median dose of Prednisone last year (mg)2,34 (2,84)sDMARDsMethotrexate104 (52%)Leflunomide29 (14,5%)Hydroxycloroquine9 (4,5%)bDMARDs89 (44,5%) TNFi41 (20,5%) Abatacept15 (7,5%) IL6i22 (11%) RTX11 (5,5%)JAKi26 (13%) Baricitinib11 (5,5%) Tofacitinib15 (7,5%)DAS 28-ESR3,1 (2,3, 3,9)SDAI7,85 (4,04, 13,41)HAQ0,88 (0,22, 1,5)RF (U/mL)51 (15, 164,25)Anti-CCP (U/mL)173 (22, 340)Patients showed higher intima-media (both right and left) thickness compared to controls (p<0.006). Moreover it was also related to the disease duration and DAS28 score (p<0.001). A higher plaque account was noted in cases(p<0.004) and it was also related to the disease duration (p<0.001).Conclusion:RA implies a higher CV risk. Traditional CV risk factors explains only partially the global risk. These findings support that RA acts as an independent cardiovascular risk factor.Disclosure of Interests:None declared

scholarly journals A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153316 ◽  
Author(s):  
Lucia Vernerova ◽  
Frantisek Spoutil ◽  
Miroslav Vlcek ◽  
Katarina Krskova ◽  
Adela Penesova ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Ambient air pollution exposures and risk of rheumatoid arthritis: results from the Swedish EIRA case–control study

2012 ◽  
Vol 72 (6) ◽  
pp. 888-894 ◽  
Author(s):  
Jaime E Hart ◽  
Henrik Källberg ◽  
Francine Laden ◽  
Tom Bellander ◽  
Karen H Costenbader ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Air Pollution ◽  
Case Control Study ◽  
Ambient Air ◽  
Case Control ◽  
Ambient Air Pollution ◽  
Control Study

scholarly journals AB0360 Left atrial dilation is increased in patients with rheumatoid arthritis: a case-control study

2018 ◽  
Author(s):  
D.A. Galarza-Delgado ◽  
J.R. Azpiri-López ◽  
I.J. Colunga-Pedraza ◽  
J.A. Dávila-Jiménez ◽  
E.E. Abundis-Márquez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Left Atrial ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Anthrax Vaccine and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus in the U.S. Military: A Case–Control Study

2016 ◽  
Vol 181 (10) ◽  
pp. 1348-1356 ◽  
Author(s):  
Barbara H. Bardenheier ◽  
Jonathan Duffy ◽  
Susan K. Duderstadt ◽  
Jay B. Higgs ◽  
Michael P. Keith ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Case Control ◽  
Systemic Lupus ◽  
Anthrax Vaccine ◽  
Control Study ◽  
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