scholarly journals A sequence-based approach demonstrates that balancing selection in classical human leukocyte antigen (HLA) loci is asymmetric

2012 ◽  
Vol 22 (2) ◽  
pp. 252-261 ◽  
Author(s):  
P. G. Bronson ◽  
S. J. Mack ◽  
H. A. Erlich ◽  
M. Slatkin
Keyword(s):  
Human Leukocyte Antigen ◽  
Balancing Selection ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Classical Human Leukocyte Antigen

scholarly journals Balancing selection and heterogeneity across the classical human leukocyte antigen loci: A meta-analytic review of 497 population studies

2008 ◽  
Vol 69 (7) ◽  
pp. 443-464 ◽  
Author(s):  
Owen D. Solberg ◽  
Steven J. Mack ◽  
Alex K. Lancaster ◽  
Richard M. Single ◽  
Yingssu Tsai ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Population Studies ◽  
Balancing Selection ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Analytic Review ◽  
Classical Human Leukocyte Antigen

scholarly journals HLA and Infectious Diseases

2009 ◽  
Vol 22 (2) ◽  
pp. 370-385 ◽  
Author(s):  
Jenefer M. Blackwell ◽  
Sarra E. Jamieson ◽  
David Burgner
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Human Leukocyte Antigen ◽  
Molecular Basis ◽  
Selective Pressure ◽  
Human Leukocyte ◽  
Acquired Immunity ◽  
Leukocyte Antigen ◽  
Extreme Variability ◽  
Classical Human Leukocyte Antigen

SUMMARY Following their discovery in the early 1970s, classical human leukocyte antigen (HLA) loci have been the prototypical candidates for genetic susceptibility to infectious disease. Indeed, the original hypothesis for the extreme variability observed at HLA loci (H-2 in mice) was the major selective pressure from infectious diseases. Now that both the human genome and the molecular basis of innate and acquired immunity are understood in greater detail, do the classical HLA loci still stand out as major genes that determine susceptibility to infectious disease? This review looks afresh at the evidence supporting a role for classical HLA loci in susceptibility to infectious disease, examines the limitations of data reported to date, and discusses current advances in methodology and technology that will potentially lead to greater understanding of their role in infectious diseases in the future.

scholarly journals A Unique Regulation Region in the 3′ UTR of HLA-G with a Promising Potential

2020 ◽  
Vol 21 (3) ◽  
pp. 900 ◽  
Author(s):  
Adi Reches ◽  
Orit Berhani ◽  
Ofer Mandelboim
Keyword(s):  
Human Leukocyte Antigen ◽  
Expression Pattern ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Human Leukocyte ◽  
Hla Class I ◽  
Leukocyte Antigen ◽  
Distinct Site ◽  
Human Leukocyte Antigen G ◽  
Classical Human Leukocyte Antigen

Human leukocyte antigen G (HLA-G) is a non-classical human leukocyte antigen (HLA) class I protein that interacts with inhibitory receptors and is commonly overexpressed in various cancers, thereby establishing itself as an inhibitory checkpoint immune ligand. It is also expressed in trophoblast cells during pregnancy and protects the fetus from immune rejection. Despite its crucial role and its intriguing expression pattern, the regulation of HLA-G’s expression is only partially understood. HLA-G’s mRNA is expressed in many tissues but the protein expression is restricted only to the cells mentioned above. Therefore, we suggest that HLA-G is post-transcriptionally regulated. Here, we reveal a distinctive site present only in the 3′ Untranslated region (UTR) of HLA-G, which might explain its unique expression pattern. Consequently, we attempted to find binding factors such as RNA binding proteins (RBPs) and microRNAS (miRs) that regulate HLA-G expression by interacting with this distinct site present in its 3′ UTR. Our research indicates that this site should be further studied in order to reveal its significance.

scholarly journals Non-classical human leukocyte antigen class I in Tunisian children with autism

2020 ◽  
Vol 45 (2) ◽  
pp. 176-183
Author(s):  
Najla Kharrat ◽  
Rania Abdelhedi ◽  
Imen Gtif ◽  
Imen Ayadi ◽  
Roberta Rizzo ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte Antigen Class ◽  
Human Leukocyte ◽  
Children With Autism ◽  
Class I ◽  
Leukocyte Antigen ◽  
Classical Human Leukocyte Antigen ◽  
Leukocyte Antigen Class I

scholarly journals Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

2020 ◽  
Vol 87 (5) ◽  
pp. 419-430 ◽  
Author(s):  
Kylie P. Glanville ◽  
Jonathan R.I. Coleman ◽  
Ken B. Hanscombe ◽  
Jack Euesden ◽  
Shing Wan Choi ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Classical Human Leukocyte Antigen

scholarly journals Non-Classical Human Leukocyte Antigen-G Allelic Diversity Among North Indians

2017 ◽  
Vol 2 (1) ◽  
pp. 1-9
Author(s):  
Swayam Prakash ◽  
◽  
Maneesh Kumar Misra ◽  
Suraksha Agrawal ◽  
◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Allelic Diversity ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
North Indians ◽  
Human Leukocyte Antigen G ◽  
Classical Human Leukocyte Antigen

Abstract # OR-8: Serum 25-Hydroxyvitamin D Associates with Human Leukocyte Antigen (HLA) Polymorphisms

2016 ◽  
Vol 22 ◽  
pp. 6
Author(s):  
Leena Kinnunen ◽  
Valma Harjutsalo ◽  
Heljä-Marja Surcel ◽  
Christel Lamberg-Allardt ◽  
Jaakko Tuomilehto ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D
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