scholarly journals Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up

2012 ◽  
Vol 21 (12) ◽  
pp. 2825-2835 ◽  
Author(s):  
Jose-Ezequiel Martin ◽  
Jasper C. Broen ◽  
F. David Carmona ◽  
Maria Teruel ◽  
Carmen P. Simeon ◽  
...  
Keyword(s):  
Risk Factor ◽  
Systemic Sclerosis ◽  
Association Study ◽  
Genetic Risk ◽  
Genome Wide Association Study ◽  
Genetic Risk Factor ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals Genome-Wide Association Study Identifies a Novel Genetic Risk Factor for Recurrent Venous Thrombosis

2018 ◽  
Vol 11 (2) ◽  
Author(s):  
Hugoline G. de Haan ◽  
Astrid van Hylckama Vlieg ◽  
Marine Germain ◽  
Trevor P. Baglin ◽  
Jean-François Deleuze ◽  
...  
Keyword(s):  
Risk Factor ◽  
Venous Thrombosis ◽  
Association Study ◽  
Genetic Risk ◽  
Genome Wide Association Study ◽  
Genetic Risk Factor ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Recurrent Venous Thrombosis

scholarly journals A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

2014 ◽  
Vol 16 (1) ◽  
pp. R6 ◽  
Author(s):  
Elena López-Isac ◽  
Lara Bossini-Castillo ◽  
Carmen P Simeon ◽  
María Egurbide ◽  
Juan Alegre-Sancho ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-Wide Association Study of Prevalent and Persistent Cervical High-Risk Human Papillomavirus(HPV) Infection

2019 ◽  
Author(s):  
Sally N. Adebamowo ◽  
Adebowale A Adeyemo ◽  
Charles N Rotimi ◽  
Olayinka Olaniyan ◽  
Richard B. Offiong ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Principal Component ◽  
Hpv Infection ◽  
Genome Wide Association ◽  
Replication Studies ◽  
Genome Wide

Abstract Background: Genetic factors may influence the susceptibility to high-risk human papillomavirus (hrHPV) infection and persistence. We conducted the first genome-wide association study (GWAS) to identify variants associated with cervical hrHPV infection and persistence. Methods: Participants were 517 Nigerian women evaluated at baseline and 6 months follow-up visits for HPV. HPV was characterized using SPF10/LiPA25. hrHPV infection was positive if at least one carcinogenic HPV genotype was detected in a sample provided at the baseline visit and persistent if at least one carcinogenic HPV genotype was detected in each of the samples provided at the baseline and follow-up visits. Genotyping was done using the Illumina Multi-Ethnic Genotyping Array (MEGA) and imputation was done using the African Genome Resources Haplotype Reference Panel. Association analysis was done under additive genetic models adjusted for age, HIV status and the first principal component (PC) of the genotypes. Results: The mean (±SD) age of the study participants was 38 (±8) years, 48% were HIV negative, 24% were hrHPV positive and 10% had persistent hrHPV infections. The top three variants associated with hrHPV infections were intronic variants clustered in KLF12 (all OR: 7.06, p=1.43 x 10-6). The top variants associated with cervical hrHPV persistence were in DAP(OR: 6.86, p=7.15 x 10-8), NR5A2(OR: 3.65, p=2.03 x 10-7) and MIR365-2(OR: 7.71, p=2.63 x 10-7) gene regions. Conclusions: This exploratory GWAS yielded novel candidate risk loci for cervical hrHPV infection and persistence. The identified loci have biological annotation and functional data supporting their role in hrHPV infection and persistence. Given our limited sample size, larger discovery and replication studies are warranted to further characterize the reported associations.

scholarly journals Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction

Circulation ◽  
2011 ◽  
Vol 124 (25) ◽  
pp. 2855-2864 ◽  
Author(s):  
Christopher J. O'Donnell ◽  
Maryam Kavousi ◽  
Albert V. Smith ◽  
Sharon L.R. Kardia ◽  
Mary F. Feitosa ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Association Study ◽  
Coronary Artery Calcification ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy

PLoS Genetics ◽  
2017 ◽  
Vol 13 (2) ◽  
pp. e1006637 ◽  
Author(s):  
Vinicius M. Fava ◽  
Jeremy Manry ◽  
Aurélie Cobat ◽  
Marianna Orlova ◽  
Nguyen Van Thuc ◽  
...  
Keyword(s):  
Risk Factor ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Inflammatory Responses ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome
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