scholarly journals Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway

2009 ◽  
Vol 18 (23) ◽  
pp. 4677-4687 ◽  
Author(s):  
Aditi Hazra ◽  
Peter Kraft ◽  
Ross Lazarus ◽  
Constance Chen ◽  
Stephen J. Chanock ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
Metabolism Pathway ◽  
Genome Wide ◽  
One Carbon Metabolism ◽  
The One

scholarly journals Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 580
Author(s):  
Camilo G. Sotomayor ◽  
Isidor Minović ◽  
Manfred L. Eggersdorfer ◽  
Ineke J. Riphagen ◽  
Martin H. de Borst ◽  
...  
Keyword(s):  
Vitamin E ◽  
Carbon Metabolism ◽  
Serum Vitamin ◽  
Elderly Subjects ◽  
Vitamin Supplement ◽  
Total Lipids ◽  
Metabolism Pathway ◽  
Age Related ◽  
One Carbon Metabolism ◽  
The One

Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60–75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.

Genetic Variants in One-Carbon Metabolism Pathway Predict Survival Outcomes of Early-Stage Non-Small Cell Lung Cancer

Oncology ◽  
2020 ◽  
Vol 98 (12) ◽  
pp. 897-904
Author(s):  
Sook Kyung Do ◽  
Sun Ha Choi ◽  
Shin Yup Lee ◽  
Jin Eun Choi ◽  
Hyo-Gyoung Kang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Carbon Metabolism ◽  
Genetic Variants ◽  
Early Stage ◽  
Small Cell ◽  
Survival Outcomes ◽  
Small Cell Lung ◽  
Metabolism Pathway ◽  
One Carbon Metabolism ◽  
The One

<b><i>Background:</i></b> This study was conducted to investigate the association between genetic variants in one-carbon metabolism and survival outcomes of surgically resected non-small cell lung cancer (NSCLC). <b><i>Methods:</i></b> We genotyped 41 potentially functional variants of 19 key genes in the one-carbon metabolism pathway among 750 NSCLC patients who underwent curative surgery. The association between genetic variants and overall survival (OS)/disease-free survival (DFS) were analyzed. <b><i>Results:</i></b> Among the 41 single-nucleotide polymorphisms (SNPs) analyzed, 4 SNPs (<i>MTHFD1L</i> rs6919680T&#x3e;G and rs3849794T&#x3e;C, <i>MTR</i> rs2853523C&#x3e;A, and <i>MTHFR</i> rs4846049G&#x3e;T) were significantly associated with survival outcomes. <i>MTHFD1L</i> rs6919680T&#x3e;G and <i>MTR</i> rs2853523C&#x3e;A were significantly associated with better OS (adjusted hazard ratio [aHR] = 0.73, 95% confidence interval [CI] = 0.54–0.99, <i>p</i> = 0.04) and worse OS (aHR = 2.14, 95% CI = 1.13–4.07, <i>p</i> = 0.02), respectively. <i>MTHFD1L</i> rs3849794T&#x3e;C and <i>MTHFR</i> rs4846049G&#x3e;T were significantly associated with worse DFS (aHR = 1.41, 95% CI = 1.08–1.83, <i>p</i> = 0.01; and aHR = 1.97, 95% CI = 1.10–3.53, <i>p</i> = 0.02, respectively). When the patients were divided according to histology, the associations were significant only in squamous cell carcinoma (SCC), but not in adenocarcinoma (AC). In SCC, <i>MTHFD1L</i> rs6919680T&#x3e;G and <i>MTR</i> rs2853523C&#x3e;A were significantly associated with better OS (aHR = 0.64, 95% CI = 0.41–1.00, <i>p</i> = 0.05) and worse OS (aHR = 2.77, 95% CI = 1.11–6.91, <i>p</i> = 0.03), respectively, and <i>MTHFD1L</i> rs3849794T&#x3e;C and <i>MTHFR</i> rs4846049G&#x3e;T were significantly associated with worse DFS (aHR = 1.73, 95% CI = 1.17–2.56, <i>p</i> = 0.01; and aHR = 2.78, 95% CI = 1.12–6.88, <i>p</i> = 0.03, respectively). <b><i>Conclusions:</i></b> Our results suggest that the genetic variants in the one-carbon metabolism pathway could be used as biomarkers for predicting the clinical outcomes of patients with early-stage NSCLC.

scholarly journals Gene expression profiles of the one-carbon metabolism pathway

2009 ◽  
Vol 36 (5) ◽  
pp. 277-282 ◽  
Author(s):  
Yin Leng Lee ◽  
Xinran Xu ◽  
Sylvan Wallenstein ◽  
Jia Chen
Keyword(s):  
Gene Expression ◽  
Carbon Metabolism ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Metabolism Pathway ◽  
One Carbon Metabolism ◽  
The One

scholarly journals Nonsynonymous Polymorphisms in Genes in the One-Carbon Metabolism Pathway and Associations with Colorectal Cancer

2006 ◽  
Vol 15 (12) ◽  
pp. 2408-2417 ◽  
Author(s):  
Anita Koushik ◽  
Peter Kraft ◽  
Charles S. Fuchs ◽  
Susan E. Hankinson ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Carbon Metabolism ◽  
Metabolism Pathway ◽  
One Carbon Metabolism ◽  
The One

scholarly journals Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer

2009 ◽  
Vol 21 (3) ◽  
pp. 331-345 ◽  
Author(s):  
Aditi Hazra ◽  
Charles S. Fuchs ◽  
Takako Kawasaki ◽  
Gregory J. Kirkner ◽  
David J. Hunter ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Carbon Metabolism ◽  
Metabolism Pathway ◽  
One Carbon Metabolism ◽  
The One

scholarly journals The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review)

2017 ◽  
Vol 50 (4) ◽  
pp. 1057-1063 ◽  
Author(s):  
Masamitsu Konno ◽  
Ayumu Asai ◽  
Koichi Kawamoto ◽  
Naohiro Nishida ◽  
Taroh Satoh ◽  
...  
Keyword(s):  
Gastrointestinal Cancer ◽  
Carbon Metabolism ◽  
Therapeutic Targets ◽  
Metabolism Pathway ◽  
Cancer Review ◽  
One Carbon Metabolism ◽  
The One
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