Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6

2006 ◽  
Vol 15 (18) ◽  
pp. 2732-2742 ◽  
Author(s):  
Ming-Shiu Hung ◽  
Philip Avner ◽  
Ute Christine Rogner
Keyword(s):  
Type 1 Diabetes ◽  
Transcription Factor ◽  
Candidate Gene

scholarly journals Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes

Diabetes Care ◽  
2018 ◽  
Vol 41 (12) ◽  
pp. 2480-2486 ◽  
Author(s):  
Maria J. Redondo ◽  
Andrea K. Steck ◽  
Jay Sosenko ◽  
Mark Anderson ◽  
Peter Antinozzi ◽  
...  
Keyword(s):  
At Risk ◽  
Type 1 Diabetes ◽  
Transcription Factor ◽  
Gene Polymorphism ◽  
Tcf7l2 Gene

scholarly journals The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes

Diabetologia ◽  
2018 ◽  
Vol 62 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Kaiyven A. Leslie ◽  
Mark A. Russell ◽  
Kazuto Taniguchi ◽  
Sarah J. Richardson ◽  
Noel G. Morgan
Keyword(s):  
Type 1 Diabetes ◽  
Transcription Factor ◽  
Beta Cell ◽  
Cell Viability ◽  
Critical Role ◽  
Beta Cell Viability

scholarly journals BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic  -Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

Diabetes ◽  
2014 ◽  
Vol 63 (7) ◽  
pp. 2516-2527 ◽  
Author(s):  
L. Marroqui ◽  
I. Santin ◽  
R. S. Dos Santos ◽  
L. Marselli ◽  
P. Marchetti ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Candidate Gene ◽  
Risk Gene ◽  
Pancreatic Cells

scholarly journals Tet2 Controls β cells Responses to Inflammation in Type 1 Diabetes

2020 ◽  
Author(s):  
Jinxiu Rui ◽  
Songyan Deng ◽  
Gerald Ponath ◽  
Romy Kursawe ◽  
Nathan Lawlor ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Type 1 Diabetes ◽  
Transcription Factor ◽  
Immune Cells ◽  
Binding Sites ◽  
Transcription Factor Binding Sites ◽  
Bone Marrow Transplants ◽  
Β Cells

Abstractβ cells may participate and contribute to their own demise during Type 1 diabetes (T1D). We identified a novel role of Tet2 in regulating immune killing of β cells. Tet2 is induced in murine and human β cells with inflammation but its expression is reduced in surviving β cells. Tet2-KO mice that receive WT bone marrow transplants develop insulitis but not diabetes and islet infiltrates do not eliminate β cells even though immune cells from the mice can transfer diabetes to NOD/scid recipients. Tet2-KO β cells show reduced expression of inflammatory genes, associated with closed transcription factor binding sites. Tet2-KO recipients are protected from transfer of disease by diabetogenic immune cells. We conclude that Tet2 regulates pathologic interactions between β cells and immune cells and controls intrinsic protective pathways. Modulating TET2 may enable survival of β cells or their replacements in the setting of pathologic immune cells.

Complete mutation scanning of the human SEL 1L gene: a candidate gene for type 1 diabetes

2001 ◽  
Vol 38 (4) ◽  
pp. 191-192 ◽  
Author(s):  
Z. M. Larsen ◽  
A. D. Angelo ◽  
M. Cattaneo ◽  
J. Nerup ◽  
I. Biunno ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Candidate Gene ◽  
Mutation Scanning

scholarly journals PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

Diabetes ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 3279-3288 ◽  
Author(s):  
I. Santin ◽  
F. Moore ◽  
M. L. Colli ◽  
E. N. Gurzov ◽  
L. Marselli ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Candidate Gene ◽  
Cell Apoptosis ◽  
Pancreatic Cell

Association of SUMO4, as a Candidate Gene for IDDM5, with Susceptibility to Type 1 Diabetes in Asian Populations

2006 ◽  
Vol 1079 (1) ◽  
pp. 41-46 ◽  
Author(s):  
S. NOSO ◽  
H. IKEGAMI ◽  
T. FUJISAWA ◽  
Y. KAWABATA ◽  
K. ASANO ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Candidate Gene ◽  
Asian Populations

scholarly journals The type 1 diabetes candidate gene Dexi does not affect disease risk in the nonobese diabetic mouse model

2019 ◽  
Vol 21 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Janice M. Nieves-Bonilla ◽  
Badr Kiaf ◽  
Cornelia Schuster ◽  
Stephan Kissler
Keyword(s):  
Type 1 Diabetes ◽  
Mouse Model ◽  
Candidate Gene ◽  
Disease Risk ◽  
Diabetic Mouse ◽  
Nonobese Diabetic Mouse ◽  
Nonobese Diabetic ◽  
Diabetes Candidate Gene
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