scholarly journals Mitochondrial DNA segregation in hematopoietic lineages does not depend on MHC presentation of mitochondrially encoded peptides

2005 ◽  
Vol 14 (17) ◽  
pp. 2587-2594 ◽  
Author(s):  
Brendan J. Battersby ◽  
Margaret E. Redpath ◽  
Eric A. Shoubridge
Keyword(s):  
Mitochondrial Dna ◽  
Dna Segregation ◽  
Mhc Presentation

scholarly journals Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division

2015 ◽  
Vol 25 (4) ◽  
pp. 706-714 ◽  
Author(s):  
Riikka Jokinen ◽  
Paula Marttinen ◽  
James B. Stewart ◽  
T. Neil Dear ◽  
Brendan J. Battersby
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Division ◽  
Tissue Specific ◽  
Dna Segregation

scholarly journals Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria

2016 ◽  
Vol 113 (30) ◽  
pp. E4276-E4285 ◽  
Author(s):  
Gokhan Akman ◽  
Radha Desai ◽  
Laura J. Bailey ◽  
Takehiro Yasukawa ◽  
Ilaria Dalla Rosa ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Control Region ◽  
Mitochondrial Disease ◽  
Genetic Information ◽  
Disease Mechanism ◽  
Dna Segregation ◽  
D Loop ◽  
Mitochondrial Dna Replication ◽  
Pathological Variant ◽  
Potential Substrate

The genetic information in mammalian mitochondrial DNA is densely packed; there are no introns and only one sizeable noncoding, or control, region containing key cis-elements for its replication and expression. Many molecules of mitochondrial DNA bear a third strand of DNA, known as “7S DNA,” which forms a displacement (D-) loop in the control region. Here we show that many other molecules contain RNA as a third strand. The RNA of these R-loops maps to the control region of the mitochondrial DNA and is complementary to 7S DNA. Ribonuclease H1 is essential for mitochondrial DNA replication; it degrades RNA hybridized to DNA, so the R-loop is a potential substrate. In cells with a pathological variant of ribonuclease H1 associated with mitochondrial disease, R-loops are of low abundance, and there is mitochondrial DNA aggregation. These findings implicate ribonuclease H1 and RNA in the physical segregation of mitochondrial DNA, perturbation of which represents a previously unidentified disease mechanism.

Nuclear genetic control of mitochondrial DNA segregation

2003 ◽  
Vol 33 (2) ◽  
pp. 183-186 ◽  
Author(s):  
Brendan J. Battersby ◽  
J.C. Loredo-Osti ◽  
Eric A. Shoubridge
Keyword(s):  
Mitochondrial Dna ◽  
Genetic Control ◽  
Dna Segregation

Insight into mammalian mitochondrial DNA segregation

2012 ◽  
Vol 45 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Riikka Jokinen ◽  
Brendan J. Battersby
Keyword(s):  
Mitochondrial Dna ◽  
Dna Segregation ◽  
Insight Into

scholarly journals Gimap3 Regulates Tissue-Specific Mitochondrial DNA Segregation

PLoS Genetics ◽  
2010 ◽  
Vol 6 (10) ◽  
pp. e1001161 ◽  
Author(s):  
Riikka Jokinen ◽  
Paula Marttinen ◽  
Helen Katarin Sandell ◽  
Tuula Manninen ◽  
Heli Teerenhovi ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Tissue Specific ◽  
Dna Segregation

scholarly journals Structure-function analysis reveals a DNA polymerization-independent role for mitochondrial DNA polymerase IC in African trypanosomes

2019 ◽  
Author(s):  
Jonathan C Miller ◽  
Stephanie B Delzell ◽  
Jeniffer Concepción-Acevedo ◽  
Michael J Boucher ◽  
Michele M Klingbeil
Keyword(s):  
Cell Cycle ◽  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Function Analysis ◽  
Point Mutations ◽  
Rnai Phenotype ◽  
African Trypanosomes ◽  
Dna Segregation ◽  
Summary Statement ◽  
Mitochondrial Dna Polymerase

ABSTRACTThe mitochondrial DNA of Trypanosoma brucei and related parasites is a catenated network containing thousands of minicircles and tens of maxicircles called kinetoplast DNA (kDNA). Replication of the single nucleoid requires at least three DNA polymerases (POLIB, POLIC, and POLID) each having discrete localization near the kDNA during S phase. POLIB and POLID have roles in minicircle replication while the specific role of POLIC in kDNA maintenance is less clear. Here, we use an RNAi-complementation system to dissect the functions of the distinct POLIC domains: the conserved family A DNA polymerase domain (POLA) and the uncharacterized N-terminal region (UCR). While RNAi complementation with wild-type POLIC restored kDNA content and cell cycle localization, active site point mutations in the POLA domain impaired minicircle replication similarly to POLIB and POLID depletions. Complementation with the POLA domain alone abolished POLIC foci formation and partially rescued the RNAi phenotype. Furthermore, we provide evidence of a crucial role for the UCR in cell cycle localization and segregation of kDNA daughter networks. This is the first report of a DNA polymerase that impacts DNA segregation.Summary statementMitochondrial DNA segregation in African trypanosomes is supported by a dual-functioning DNA polymerase.

Two distinct types of mitochondrial DNA segregation in mouse-rat hybrid cells

1983 ◽  
Vol 147 (1) ◽  
pp. 51-61 ◽  
Author(s):  
Jun-Ichi Hayashi ◽  
Yusaku Tagashira ◽  
Michihiro C. Yoshida ◽  
Kozo Ajiro ◽  
Toyozo Sekiguchi
Keyword(s):  
Mitochondrial Dna ◽  
Hybrid Cells ◽  
Dna Segregation
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